Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-09-2017 | Laryngology

Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy

Authors: Min Chen, Jian Chen, Lei Cheng, Haitao Wu

Published in: European Archives of Oto-Rhino-Laryngology | Issue 9/2017

Abstract

This work aims to analyze the recurrence of vocal fold leukoplakia after carbon dioxide (CO₂) laser resection. In this retrospective study, all patients undergoing CO₂ laser resection of vocal fold leukoplakia were followed up for at least 2 years. Recurrence was diagnosed as any presence of leukoplakia in the vocal cord subsequent to previous successful complete resection. A total of 326 patients with complete resection of vocal fold leukoplakia and follow-up subsequent surveillance laryngoscopy were studied. The recurrence rate, the recurrence time, and risk factors were evaluated. Of these, 52 (16.0%) patients experienced recurrence with a mean follow-up time of 50.5 ± 15.4 months. The mean time to recurrence was 16.2 ± 14.1 months. Univariate analysis showed that the size of lesion (P < 0.001, Pearson χ ² test; P < 0.001, log-rank test) and the pathological grade (P = 0.025, Pearson χ ² test; P = 0.028, log-rank test) were significantly related to recurrence. The size of lesion was an independent prognostic factor for recurrence using multivariate analysis (P = 0.001, logistic regression; P = 0.001, Cox proportional hazards model). Considering the possible recurrence of vocal fold leukoplakia, long-term follow-up is required after CO₂ laser resection. In conclusion, the size of lesion combined with the pathological grade are important risk factors that predict vocal fold leukoplakia recurrence.

Available only for authorised users

Panwar A, Lindau RR, Wieland A (2013) Management of premalignant lesions of the larynx. Expert Rev Anticancer Ther 13(9):1045–1051CrossRefPubMed

Thompson L (2006) World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 85(2):74PubMed

Mehanna H, Paleri V, Robson A, Wight R, Helliwell T (2010) Consensus statement by otorhinolaryngologists and pathologists on the diagnosis and management of laryngeal dysplasia. Clin Otolaryngol 35(3):170–176CrossRefPubMed

Spielmann PM, Palmer T, McClymont L (2010) 15-year review of laryngeal and oral dysplasias and progression to invasive carcinoma. Eur Arch Otorhinolaryngol 267(3):423–427CrossRefPubMed

Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM (2010) The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol 35(5):364–372CrossRefPubMed

Minni A, Barbaro M, Rispoli G, Diaferia F, Bernardeschi D, Filipo R (2008) Treatment with laser CO₂ cordectomy and clinical implications in management of mild and moderate laryngeal precancerosis. Eur Arch Otorhinolaryngol 265(2):189–193CrossRefPubMed

Dispenza F, De Stefano A, Marchese D, Martines F, Dispenza C (2012) Management of laryngeal precancerous lesions. Auris Nasus Larynx 39(3):280–283CrossRefPubMed

Sadri M, McMahon J, Parker A (2006) Management of laryngeal dysplasia: a review. Eur Arch Otorhinolaryngol 263(9):843–852CrossRefPubMed

Zhukhovitskaya A, Battaglia D, Khosla SM, Murry T, Sulica L (2015) Gender and age in benign vocal fold lesions. Laryngoscope 125(1):191–196CrossRefPubMed

10.

Chainani-Wu N, Lee D, Madden E, Sim C, Collins K, Silverman SJ (2015) Clinical predictors of oral leukoplakia recurrence following CO₂ laser vaporization. J Craniomaxillofac Surg 43(9):1875–1879CrossRefPubMed

11.

Kuribayashi Y, Tsushima F, Sato M, Morita K, Omura K (2012) Recurrence patterns of oral leukoplakia after curative surgical resection: important factors that predict the risk of recurrence and malignancy. J Oral Pathol Med 41(9):682–688CrossRefPubMed

12.

Jerjes W, Upile T, Hamdoon Z et al (2012) CO₂ laser of oral dysplasia: clinicopathological features of recurrence and malignant transformation. Lasers Med Sci 27(1):169–179CrossRefPubMed

13.

Del CG, Gissi DB, Tarsitano A et al (2015) Laser evaporation versus laser excision of oral leukoplakia: a retrospective study with long-term follow-up. J Craniomaxillofac Surg 43(6):763–768CrossRef

14.

Deppe H, Mucke T, Hohlweg-Majert B, Hauck W, Wagenpfeil S, Holzle F (2012) Different CO₂ laser vaporization protocols for the therapy of oral precancerous lesions and precancerous conditions: a 10-year follow-up. Lasers Med Sci 27(1):59–63CrossRefPubMed

15.

Yang SW, Chao WC, Lee YS et al (2017) Treatment outcome of vocal cord leukoplakia by transoral laser microsurgery. Lasers Med Sci 32(1):19–27CrossRefPubMed

16.

Young CK, Lin WN, Lee LY et al (2015) Laryngoscopic characteristics in vocal leukoplakia: inter-rater reliability and correlation with histology grading. Laryngoscope 125(2):E62–E66CrossRefPubMed

17.

Lee DH, Yoon TM, Lee JK, Lim SC (2015) Predictive factors of recurrence and malignant transformation in vocal cord leukoplakia. Eur Arch Otorhinolaryngol 272(7):1719–1724CrossRefPubMed

18.

Zhang Y, Liang G, Sun N et al (2015) Comparison of CO₂ laser and conventional laryngomicrosurgery treatments of polyp and leukoplakia of the vocal fold. Int J Clin Exp Med 8(10):18265–18274PubMedPubMedCentral

19.

Park YM, Jo KH, Hong HJ, Choi HS (2014) Phonatory outcome of 585 nm/pulsed-dye laser in the management of glottic leukoplakia. Auris Nasus Larynx 41(5):459–463CrossRefPubMed

20.

Zhou Jian, Zhang Duo, Zhou Liang et al (2016) Association of the recurrence and canceration rate of vocal leukoplakia with interleukin-10 promoter variants over a 2-year period. Acta Otolaryngol 136(11):1147–1153CrossRefPubMed

21.

Hamadah O, Goodson ML, Thomson PJ (2010) Clinicopathological behaviour of multiple oral dysplastic lesions compared with that of single lesions. Br J Oral Maxillofac Surg 48(7):503–506CrossRefPubMed

22.

Saito T, Sugiura C, Hirai A et al (1999) High malignant transformation rate of widespread multiple oral leukoplakias. Oral Dis 5(1):15–19CrossRefPubMed

23.

Jaiswal G, Jaiswal S, Kumar R, Sharma A (2013) Field cancerization: concept and clinical implications in head and neck squamous cell carcinoma. J Exp Ther Oncol 10(3):209–214PubMed

24.

Mogedas-Vegara A, Hueto-Madrid JA, Chimenos-Kustner E, Bescos-Atin C (2015) The treatment of oral leukoplakia with the CO₂ laser: a retrospective study of 65 patients. J Craniomaxillofac Surg 43(5):677–681CrossRefPubMed

Title: Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy
Authors: Min Chen
Jian Chen
Lei Cheng
Haitao Wu
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 9/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-017-4632-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 9/2017

Erratum to: Exercise induced laryngeal obstruction: a review of diagnosis and management

The role of insulin-like growth factor I–II receptor on development of pleomorphic adenoma

Butterfly cartilage tympanoplasty: an alternative new technique instead of conventional surgery method

Evidence-based medicine in plastic surgery

The role of local allergy in the nasal inflammation

The clinical outcomes of using a new cross-linked hyaluronan gel in endoscopic frontal sinus surgery