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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 12/2016

01-12-2016 | Review Article

Antileukotrienes in adenotonsillar hypertrophy: a review of the literature

Authors: Murat Kar, Niyazi Altıntoprak, Nuray Bayar Muluk, Seckin Ulusoy, Sameer Ali Bafaqeeh, Cemal Cingi

Published in: European Archives of Oto-Rhino-Laryngology | Issue 12/2016

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Abstract

We assessed the use of antileukotrienes for treating adenotonsillar hypertrophy. We reviewed the current literature on the anatomy of adenotonsillar tissue, adenotonsillar hypertrophy/hyperplasia (and the associated pathophysiology and symptoms), and the effects of antileukotrienes used to treat adenotonsillar hypertrophy. Leukotrienes (LTs) are inflammatory mediators produced by a number of cell types, including mast cells, eosinophils, basophils, macrophages, and monocytes. There are several types (e.g., LTA4, LTB4, LTC4, LTD4, and LTE4). By competitive binding to the cysLT1 receptor, LT-receptor antagonist drugs such as montelukast, zafirlukast, and pranlukast block the effects of cySHLTs, improving the symptoms of some chronic respiratory diseases. High numbers of LT receptors have been found in the tonsils of children with obstructive sleep apnea. Antileukotrienes reduce the apnea–hypopnea index and adenotonsillar inflammation. Antileukotrienes may be useful for children with adenotonsillar hypertrophy due to their anti-inflammatory effects, which help to reduce adenotonsillar inflammation.
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Metadata
Title
Antileukotrienes in adenotonsillar hypertrophy: a review of the literature
Authors
Murat Kar
Niyazi Altıntoprak
Nuray Bayar Muluk
Seckin Ulusoy
Sameer Ali Bafaqeeh
Cemal Cingi
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 12/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-3983-8

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