Skip to main content
Top
Published in: European Archives of Oto-Rhino-Laryngology 10/2016

01-10-2016 | Otology

Acetazolamide in vestibular migraine prophylaxis: a retrospective study

Authors: Neşe Çelebisoy, Figen Gökçay, Ceyda Karahan, Cem Bilgen, Tayfun Kirazlı, Hale Karapolat, Timur Köse

Published in: European Archives of Oto-Rhino-Laryngology | Issue 10/2016

Login to get access

Abstract

The aim of this study is to check the efficacy of acetazolamide in the prophylaxis of vestibular migraine (VM). Treatment options in VM are mainly based on migraine guidelines. We tried to assess the efficacy of acetazolamide in these patients depending on clinical similarities with episodic ataxia type 2 and familial hemiplegic migraine responding to the drug. This is a retrospective cohort study. Among 50 patients with VM and prescribed acetazolamide 500 mg/day, 39 patients were studied as five had been lost on follow-up and six had stopped taking the drug due to side effects. Vertigo and headache frequency determined by number of attacks per month, and the severity determined by visual analog scales measured in centimeters from 0 to 10 were collected from the records. Initial reported figures for frequency and severity were compared with the results gathered after 3 months of treatment. The results were compared. Acetazolamide was effective in reducing both the frequency and severity of vertigo and headache attacks and this effect was more prominent for vertigo frequency and severity.
Literature
1.
3.
go back to reference Cass SP, Furman JM, Ankerstjerne K, Balaban C, Yetişer S, Aydogan B (1997) Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol 106:182–189CrossRefPubMed Cass SP, Furman JM, Ankerstjerne K, Balaban C, Yetişer S, Aydogan B (1997) Migraine-related vestibulopathy. Ann Otol Rhinol Laryngol 106:182–189CrossRefPubMed
5.
go back to reference Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T (2001) The interrelations of migraine, vertigo and migrainous vertigo. Neurology 56:436–441CrossRefPubMed Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T (2001) The interrelations of migraine, vertigo and migrainous vertigo. Neurology 56:436–441CrossRefPubMed
6.
go back to reference Reploeg MD, Goebel JA (2002) Migraine-associated dizziness: patient characteristics and management options. Otol Neurotol 23:364–371CrossRefPubMed Reploeg MD, Goebel JA (2002) Migraine-associated dizziness: patient characteristics and management options. Otol Neurotol 23:364–371CrossRefPubMed
7.
go back to reference Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Newman-Toker D (2012) Vestibular migraine: diagnostic criteria. J Vest Res 22:167–172 Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Newman-Toker D (2012) Vestibular migraine: diagnostic criteria. J Vest Res 22:167–172
8.
go back to reference International Headache Society Classification Subcommittee (2013) The International Classification of Headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808CrossRef International Headache Society Classification Subcommittee (2013) The International Classification of Headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808CrossRef
9.
go back to reference Neuhauser H, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, Lempert T (2006) Migrainous vertigo: prevalence and impact on quality of life. Neurology 67:1028–1033CrossRefPubMed Neuhauser H, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, Lempert T (2006) Migrainous vertigo: prevalence and impact on quality of life. Neurology 67:1028–1033CrossRefPubMed
10.
go back to reference Neff BA, Staab JP, Eggers SD, Carlson ML, Schmitt WR, Van Abel KM, Worthington DK, Beatty CW, Driscoll CL, Shepard NT (2012) Auditory and vestibular symptoms and chronic subjective dizziness in patients with Meniere’s disease, vestibular migraine and Meniere’s disease with concomitant vestibular migraine. Otol Neurotol 33:1235–1244CrossRefPubMed Neff BA, Staab JP, Eggers SD, Carlson ML, Schmitt WR, Van Abel KM, Worthington DK, Beatty CW, Driscoll CL, Shepard NT (2012) Auditory and vestibular symptoms and chronic subjective dizziness in patients with Meniere’s disease, vestibular migraine and Meniere’s disease with concomitant vestibular migraine. Otol Neurotol 33:1235–1244CrossRefPubMed
11.
go back to reference Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T (2012) Vestibular migraine: long term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology 79:1607–1614CrossRefPubMed Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T (2012) Vestibular migraine: long term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology 79:1607–1614CrossRefPubMed
12.
go back to reference Celebisoy N, Gökçay F, Sirin H, Bıçak N (2008) Migrainous vertigo: clinical, oculographic and posturographic findings. Cephalalgia 28:72–77PubMed Celebisoy N, Gökçay F, Sirin H, Bıçak N (2008) Migrainous vertigo: clinical, oculographic and posturographic findings. Cephalalgia 28:72–77PubMed
13.
go back to reference Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87:543–552CrossRefPubMed Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE (1996) Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 87:543–552CrossRefPubMed
14.
go back to reference Von Brevern M, Ta N, Shankar A, Wieste A, Siegel A, Radtke A, Sander T, Escayg A (2006) Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. Headache 46(1136–1):141 Von Brevern M, Ta N, Shankar A, Wieste A, Siegel A, Radtke A, Sander T, Escayg A (2006) Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. Headache 46(1136–1):141
15.
go back to reference Kim JS, Yue Q, Jen JC, Nelson SF, Baloh RW (1998) Familial migraine with vertigo: no mutations found in CACNA1A. Am J Med Gen 79:148–151CrossRef Kim JS, Yue Q, Jen JC, Nelson SF, Baloh RW (1998) Familial migraine with vertigo: no mutations found in CACNA1A. Am J Med Gen 79:148–151CrossRef
16.
go back to reference Lepcha A, Amalanathan S, Augustine AM, Tyagi AK, Balraj A (2014) Flunarizine in the prophylaxis of migrainous vertigo. Eur Arch Otorhinolaryngol 271:2931–2936CrossRefPubMed Lepcha A, Amalanathan S, Augustine AM, Tyagi AK, Balraj A (2014) Flunarizine in the prophylaxis of migrainous vertigo. Eur Arch Otorhinolaryngol 271:2931–2936CrossRefPubMed
17.
go back to reference Bikhazi P, Jackson C, Ruckenstein MJ (1997) Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness. Am J Otol 18:350–354PubMed Bikhazi P, Jackson C, Ruckenstein MJ (1997) Efficacy of antimigrainous therapy in the treatment of migraine-associated dizziness. Am J Otol 18:350–354PubMed
18.
go back to reference Maione A (2006) Migraine-related vertigo: diagnostic criteria and prophylactic treatment. Laryngoscope 116:1782–1786CrossRefPubMed Maione A (2006) Migraine-related vertigo: diagnostic criteria and prophylactic treatment. Laryngoscope 116:1782–1786CrossRefPubMed
19.
go back to reference Baier B, Winkenwerder E, Dieterich M (2009) “Vestibular migraine”: effects of prophylactic therapy with various drugs. A retrospective study. J Neurol 256:436–442CrossRefPubMed Baier B, Winkenwerder E, Dieterich M (2009) “Vestibular migraine”: effects of prophylactic therapy with various drugs. A retrospective study. J Neurol 256:436–442CrossRefPubMed
20.
go back to reference Bisdorff AR (2004) Treatment of migraine related vertigo with lamotrigine an observational study. Bull Soc Sci Med Grand Duche Luxemb 2:103–108PubMed Bisdorff AR (2004) Treatment of migraine related vertigo with lamotrigine an observational study. Bull Soc Sci Med Grand Duche Luxemb 2:103–108PubMed
21.
go back to reference Gode S, Celebisoy N, Kirazli T, Akyuz A, Bilgen C, Karapolat H, Sirin H, Gokcay F (2010) Clinical assessment of topiramate therapy in patients with migrainous vertigo. Headache 50:77–84CrossRefPubMed Gode S, Celebisoy N, Kirazli T, Akyuz A, Bilgen C, Karapolat H, Sirin H, Gokcay F (2010) Clinical assessment of topiramate therapy in patients with migrainous vertigo. Headache 50:77–84CrossRefPubMed
22.
go back to reference Taghdiri F, Togha M, Jahromi SR, Refaeian F (2014) Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus 3:231–235CrossRefPubMedPubMedCentral Taghdiri F, Togha M, Jahromi SR, Refaeian F (2014) Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus 3:231–235CrossRefPubMedPubMedCentral
23.
go back to reference Kohshi K, Konda N, Kinoshita Y, Tsuru E, Yokota A (1994) In situ arterial and brain tissue PCO2 responses to acetazolamide in cats. J Appl Physiol 76:2199–2203PubMed Kohshi K, Konda N, Kinoshita Y, Tsuru E, Yokota A (1994) In situ arterial and brain tissue PCO2 responses to acetazolamide in cats. J Appl Physiol 76:2199–2203PubMed
24.
go back to reference Aggarwal M, Kondeti B, McKenna R (2013) Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opin Ther Pat 23:717–724CrossRefPubMed Aggarwal M, Kondeti B, McKenna R (2013) Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review. Expert Opin Ther Pat 23:717–724CrossRefPubMed
25.
go back to reference De Simone R, Marano E, Di Stasio E, Bonuso S, Fiorillo C, Bonavita V (2005) Acetazolamide efficacy and tolerability in migraine with aura: a pilot study. Headache 45:385–386CrossRefPubMed De Simone R, Marano E, Di Stasio E, Bonuso S, Fiorillo C, Bonavita V (2005) Acetazolamide efficacy and tolerability in migraine with aura: a pilot study. Headache 45:385–386CrossRefPubMed
26.
go back to reference Robbins MS, Lipton RB, Laureta EC, Grosberg BM (2009) CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. Headache 49:1042–1046CrossRefPubMed Robbins MS, Lipton RB, Laureta EC, Grosberg BM (2009) CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. Headache 49:1042–1046CrossRefPubMed
27.
go back to reference Tricarico D, Barbieri MG, Conte Camerino D (2000) Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. Ann Neurol 48:304–312CrossRefPubMed Tricarico D, Barbieri MG, Conte Camerino D (2000) Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis. Ann Neurol 48:304–312CrossRefPubMed
28.
go back to reference Omata T, Takanashi J, Wada T, Arai H, Tanabe Y (2011) Genetic diagnosis and acetazolamide treatment of familial hemiplegic migraine. Brain Dev 33:332–334CrossRefPubMed Omata T, Takanashi J, Wada T, Arai H, Tanabe Y (2011) Genetic diagnosis and acetazolamide treatment of familial hemiplegic migraine. Brain Dev 33:332–334CrossRefPubMed
29.
go back to reference Shirai T, Meyer JS, Akiyama H, Mortel KF, Wills PM (1996) Acetazolamide testing of cerebral vasodilator capacity provokes ‘vascular’ but not tension headaches. Headache 36:589–594CrossRefPubMed Shirai T, Meyer JS, Akiyama H, Mortel KF, Wills PM (1996) Acetazolamide testing of cerebral vasodilator capacity provokes ‘vascular’ but not tension headaches. Headache 36:589–594CrossRefPubMed
30.
go back to reference Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sandor PS (2009) EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force. Eur J Neurol 16:968–981CrossRefPubMed Evers S, Afra J, Frese A, Goadsby PJ, Linde M, May A, Sandor PS (2009) EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force. Eur J Neurol 16:968–981CrossRefPubMed
31.
go back to reference Loder E, Burch R, Rizzoli P (2012) The 2012 AHS/AAN guidelines for prevention of episodic migraine: a summary and comparison with other recent clinical practice guidelines. Headache 52:930–945CrossRefPubMed Loder E, Burch R, Rizzoli P (2012) The 2012 AHS/AAN guidelines for prevention of episodic migraine: a summary and comparison with other recent clinical practice guidelines. Headache 52:930–945CrossRefPubMed
32.
go back to reference Linde M, Mulleners WM, Chronicle EP, McCrory DC (2013) Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults (review). Cochrane Database Syst Rev 6:1–58 Linde M, Mulleners WM, Chronicle EP, McCrory DC (2013) Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults (review). Cochrane Database Syst Rev 6:1–58
33.
go back to reference Baloh RW, Foster CA, Yue Q, Nelson SF (1996) Familial migraine with vertigo and essential tremor. Neurology 46:458–460CrossRefPubMed Baloh RW, Foster CA, Yue Q, Nelson SF (1996) Familial migraine with vertigo and essential tremor. Neurology 46:458–460CrossRefPubMed
Metadata
Title
Acetazolamide in vestibular migraine prophylaxis: a retrospective study
Authors
Neşe Çelebisoy
Figen Gökçay
Ceyda Karahan
Cem Bilgen
Tayfun Kirazlı
Hale Karapolat
Timur Köse
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 10/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-015-3874-4

Other articles of this Issue 10/2016

European Archives of Oto-Rhino-Laryngology 10/2016 Go to the issue