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European Archives of Oto-Rhino-Laryngology

Published in:

01-07-2016 | Rhinology

Long-term outcomes of endoscopic endonasal approach for skull base surgery: a prospective study

Authors: Elena Rioja, Manuel Bernal-Sprekelsen, Karla Enriquez, Joaquim Enseñat, Ricard Valero, Matteo de Notaris, Joaquim Mullol, Isam Alobid

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2016

Abstract

Little is known about the long-term effects of either transnasal transsphenoidal endoscopic approach (TTEA) or expanded endonasal approach (EEA). This study assessed the long-term impact of endoscopic skull base surgery on olfaction, sinonasal symptoms, mucociliary clearance time (MCT), and quality of life (QoL). Patients with pituitary adenomas underwent TTEA (n = 38), while patients with other benign parasellar tumours who underwent an EEA with vascularised septal flap reconstruction (n = 17) were enrolled in this prospective study between 2009 and 2012. Sinonasal symptoms (Visual Analogue Scale), subjective olfactometry (Barcelona Smell Test-24, BAST-24), MCT (saccharin test), and QoL (short form SF-36, rhinosinusitis outcome measure/RSOM) were evaluated before, and 12 months after, surgery. At baseline, sinonasal symptoms, MCT, BAST-24, and QoL were similar between groups. Twelve months after surgery, both TTEA and EEA groups experienced smell impairment compared to baseline. Moreover, EEA (but not TTEA) patients reported increased posterior nasal discharge and longer MCTs compared to baseline. No significant changes in olfactometry or QoL were detected in either group 12 months after surgery. Over the long-term, expanded skull base surgery, using EEA, produced more sinonasal symptoms (including loss of smell) and longer MCTs than pituitary surgery (TTEA). EEA showed no long-term impact on smell test or QoL.

Level of evidence: IIb

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Title: Long-term outcomes of endoscopic endonasal approach for skull base surgery: a prospective study
Authors: Elena Rioja
Manuel Bernal-Sprekelsen
Karla Enriquez
Joaquim Enseñat
Ricard Valero
Matteo de Notaris
Joaquim Mullol
Isam Alobid
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-015-3853-9

At a glance: The STEP trials

Springer Medicine

Long-term outcomes of endoscopic endonasal approach for skull base surgery: a prospective study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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