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European Archives of Oto-Rhino-Laryngology

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01-06-2016 | Head and Neck

(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer

Authors: Hendrik Andreas Wolff, Friedrich Ihler, Nina Zeller, Christian Welz, Klaus Jung, Martin Canis, Wolfgang Steiner

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2016

Abstract

This study analyzed the efficacy of transoral laser microsurgery and postoperative (chemo) radiotherapy (CRT) for head and neck squamous cell carcinoma. Between 1987 and 2007, 318 patients with pN2 neck disease were included. Seventy-three patients received laser resection and neck dissection alone, 154 postoperative radiotherapy, and 91 postoperative (C)RT. Mean follow-up was 58.2 ± 51.2 months, and locoregional control was significantly better after postoperative (C)RT (surgery alone: 42 %, radiotherapy: 57 %, CRT: 59 %; p < 0.01). Postoperative (C)RT did not have a significant impact on disease-specific survival (DSS) (surgery alone: 55 %, radiotherapy alone: 60 %, CRT: 64 %; p = 0.36). Fifty-seven patients (17.92 %) developed distant metastases, and 39 patients (12.26 %) presented with secondary malignancies, with no significant differences found between the treatment groups. Postoperative (C)RT significantly improved locoregional control, but had no significant effect on DSS because of high rates of secondary malignancies and distant metastases. Reduced radicality in combination with an effective screening might improve prognosis and quality of life of these patients.

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Title: (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer
Authors: Hendrik Andreas Wolff
Friedrich Ihler
Nina Zeller
Christian Welz
Klaus Jung
Martin Canis
Wolfgang Steiner
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 6/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-015-3619-4

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(Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer

Abstract

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Abstract

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