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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 3/2016

01-03-2016 | Head and Neck

Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature

Authors: Garrett D. Locketz, Gilad Horowitz, Sara Abu-Ghanem, Oshri Wasserzug, Abraham Abergel, Moshe Yehuda, Dan M. Fliss

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2016

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Abstract

The objective of the study is to present a large case series of parapharyngeal space tumors (PPST) and the most comprehensive literature review of tumor histopathologic distribution. The study was designed as internal case series and full Pubmed/MEDLINE electronic database review in a tertiary academic medical center. Tumor histopathology and patient demographics were obtained from a comprehensive Pubmed/MEDLINE database review, as well from an internal case series of 117 patients referred to our center between 1993 and 2013. Main outcome and measures of the study were to define the age, gender, and histopathology of PPST within a large internal case series and among the current body of published literature, and to propose a diagnostic and treatment algorithm for these tumors. Our cohort included 117 cases, 58 females and 59 males, with benign tumors comprising 85 % (n = 99) and malignant tumors 15 % (n = 18). A systematic review of published literature from 1963 to the present revealed 37 case series, and when combined with our present series, yielded a total of 2160 cases. Benign tumors are most common (78.8 %), with tumors of salivary gland (44.4 %), neural (34.4 %), and vascular (2.64 %) origin representing the largest subtypes. Pleomorphic adenomas (30.9 %), paragangliomas (13.1 %), and schwannomas (12.3 %) comprised the majority of all cases. Due to their rarity, data regarding the histopathologic distribution of PPST is scarce. We provide one of the largest case series and the most comprehensive review of these tumors in the literature to date, and offer our algorithm for evaluation and treatment.
Literature
1.
Cummings W Jr, Haughey BH, Thomas JR et al (2005) Cummings otolaryngology head and neck surgery, 4th edn. Mosby, St. Louis
2.
3.
Silver AJ, Mawad ME, Hilal SK, Sane P, Ganti SR (1983) Computed tomography of the nasopharynx and related spaces. Part II: pathology. Radiology 147(3):733–738CrossRefPubMed
4.
Batsakis JG, Sneige N (1989) Parapharyngeal and retropharyngeal space diseases. Ann Otol Rhinol Laryngol 98(4 Pt 1):320–321CrossRefPubMed
5.
Manolidis S, Shohet JA, Jackson CG, Glasscock ME 3rd (1999) Malignant glomus tumors. Laryngoscope 109(1):30–34CrossRefPubMed
6.
Lee JH, Barich F, Karnell LH et al (2002) National Cancer Data Base report on malignant paragangliomas of the head and neck. Cancer 94(3):730–737CrossRefPubMed
7.
Gimenez-Roqueplo AP, Favier J, Rustin P et al (2003) Mutations in the SDHB gene are associated with extra-adrenal and/or malignant pheochromocytomas. Cancer Res 63(17):5615–5621PubMed
8.
Papaspyrou K, Mewes T, Rossmann H et al (2012) Head and neck paragangliomas: report of 175 patients (1989–2010). Head Neck 34(5):632–637CrossRefPubMed
9.
Ducatman BS, Scheithauer BW, Piepgras DG, Reiman HM, Ilstrup DM (1986) Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer 57(10):2006–2021CrossRefPubMed
10.
Miller FR, Wanamaker JR, Lavertu P, Wood BG (1996) Magnetic resonance imaging and the management of parapharyngeal space tumors. Head Neck 18(1):67–77CrossRefPubMed
11.
Khafif A, Segev Y, Kaplan DM, Gil Z, Fliss DM (2005) Surgical management of parapharyngeal space tumors: a 10-year review. Otolaryngol Head Neck Surg 132(3):401–406CrossRefPubMed
12.
Oliai BR, Sheth S, Burroughs FH, Ali SZ (2005) “Parapharyngeal space” tumors: a cytopathological study of 24 cases on fine-needle aspiration. Diagn Cytopathol 32(1):11–15CrossRefPubMed
13.
14.
McIlrath DC, Remine WH (1963) Parapharyngeal tumors. Surg Clin N Am 43:1041–1047PubMed
15.
Work WP, Hybels RL (1974) A study of tumors of the parapharyngeal space. Laryngoscope 84(10):1748–1755CrossRefPubMed
16.
Som PM, Biller HF, Lawson W, Sacher M, Lanzieri CF (1984) Parapharyngeal space masses: an updated protocol based upon 104 cases. Radiology 153(1):149–156CrossRefPubMed
17.
Ferlito A, Pesavento G, Recher G, Nicolai P, Narne S, Polidoro F (1984) Assessment and treatment of neurogenic and non-neurogenic tumors of the parapharyngeal space. Head Neck Surg 7(1):32–43CrossRefPubMed
18.
19.
Shoss SM, Donovan DT, Alford BR (1985) Tumors of the parapharyngeal space. Arch Otolaryngol 111(11):753–757CrossRefPubMed
20.
Stell PM, Mansfield AO, Stoney PJ (1985) Surgical approaches to tumors of the parapharyngeal space. Am J Otolaryngol 6(2):92–97CrossRefPubMed
21.
Dankle SK (1987) Neoplasms of the parapharyngeal space. Ear Nose Throat J 66(12):491–501PubMed
22.
Allison RS, Van der Waal I, Snow GB (1989) Parapharyngeal tumours: a review of 23 cases. Clin Otolaryngol Allied Sci 14(3):199–203CrossRefPubMed
23.
Carrau RL, Myers EN, Johnson JT (1990) Management of tumors arising in the parapharyngeal space. Laryngoscope 100(6):583–589CrossRefPubMed
24.
Stanley RE (1991) Parapharyngeal space tumours. Ann Acad Med Singapore 20(5):589–596PubMed
25.
Olsen KD (1994) Tumors and surgery of the parapharyngeal space. Laryngoscope 104(5 Pt 2 Suppl 63):1–28CrossRefPubMed
26.
Pensak ML, Gluckman JL, Shumrick KA (1994) Parapharyngeal space tumors: an algorithm for evaluation and management. Laryngoscope 104(9):1170–1173CrossRefPubMed
27.
Hughes KV 3rd, Olsen KD, McCaffrey TV (1995) Parapharyngeal space neoplasms. Head Neck 17(2):124–130CrossRefPubMed
28.
29.
Tincani AJ, Martins AS, Altemani A et al (1999) Parapharyngeal space tumors: considerations in 26 cases. Sao Paulo Med J 117(1):34–37CrossRefPubMed
30.
Malone JP, Agrawal A, Schuller DE (2001) Safety and efficacy of transcervical resection of parapharyngeal space neoplasms. Ann Otol Rhinol Laryngol 110(12):1093–1098CrossRefPubMed
31.
Pang KP, Goh CH, Tan HM (2002) Parapharyngeal space tumours: an 18 year review. J Laryngol Otol 116(3):170–175CrossRefPubMed
32.
Hazarika P, Dipak RN, Parul P, Kailesh P (2004) Surgical access to parapharyngeal space tumours–the Manipal experience. Med J Malays 59(3):323–329
33.
Ulku CH, Uyar Y, Arbag H (2004) Management of parapharyngeal space tumors. Ir Med J 97(5):140–142PubMed
34.
Attia A, El-Shafiey M, El-Shazly S, Shouman T, Zaky I (2004) Management of parapharyngeal space tumors at the National Cancer Institute, Egypt. J Egypt Nat Cancer Inst 16(1):34–42PubMed
35.
Luna-Ortiz K, Navarrete-Aleman JE, Granados-Garcia M, Herrera-Gomez A (2005) Primary parapharyngeal space tumors in a Mexican cancer center. Otolaryngol Head Neck Surg 132(4):587–591CrossRefPubMed
36.
Shahab R, Heliwell T, Jones AS (2005) How we do it: a series of 114 primary pharyngeal space neoplasms. Clin Otolaryngol 30(4):364–367CrossRefPubMed
37.
Cohen SM, Burkey BB, Netterville JL (2005) Surgical management of parapharyngeal space masses. Head Neck 27(8):669–675CrossRefPubMed
38.
Farrag TY, Lin FR, Koch WM et al (2007) The role of pre-operative CT-guided FNAB for parapharyngeal space tumors. Otolaryngol Head Neck Surg 136(3):411–414CrossRefPubMed
39.
Kawashima Y, Sumi T, Sugimoto T, Kishimoto S (2008) First-bite syndrome: a review of 29 patients with parapharyngeal space tumor. Auris Nasus Larynx 35(1):109–113CrossRefPubMed
40.
Chijiwa H, Mihoki T, Shin B, Sakamoto K, Umeno H, Nakashima T (2009) Clinical study of parapharyngeal space tumours. J Laryngol Otol 123(Suppl 31):100–103CrossRef
41.
Zhi K, Ren W, Zhou H, Wen Y, Zhang Y (2009) Management of parapharyngeal-space tumors. J Oral Maxillofac Surg 67(6):1239–1244CrossRefPubMed
42.
Suarez-Fente V, Llorente-Pendas JL, Gomez-Martinez J, Garcia-Gonzalez LA, Lopez-Alvarez F, Suarez-Nieto C (2009) Primary tumours of the parapharyngeal space. Our experience in 51 patients. Acta Otorrinolaringol Esp 60(1):19–24CrossRefPubMed
43.
Dimitrijevic MV, Jesic SD, Mikic AA, Arsovic NA, Tomanovic NR (2010) Parapharyngeal space tumors: 61 case reviews. Int J Oral Maxillofac Surg 39(10):983–989CrossRefPubMed
44.
Papadogeorgakis N, Petsinis V, Goutzanis L, Kostakis G, Alexandridis C (2010) Parapharyngeal space tumors: surgical approaches in a series of 13 cases. Int J Oral Maxillofac Surg 39(3):243–250CrossRefPubMed
45.
Arnason T, Hart RD, Taylor SM, Trites JR, Nasser JG, Bullock MJ (2012) Diagnostic accuracy and safety of fine-needle aspiration biopsy of the parapharyngeal space. Diagn Cytopathol 40(2):118–123CrossRefPubMed
46.
47.
Cassoni A, Terenzi V, Della Monaca M et al (2014) Parapharyngeal space benign tumours: our experience. J Cranio-Maxillofac Surg 42(2):101–105CrossRef
Metadata
Title
Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature
Authors
Garrett D. Locketz
Gilad Horowitz
Sara Abu-Ghanem
Oshri Wasserzug
Abraham Abergel
Moshe Yehuda
Dan M. Fliss
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 3/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-015-3545-5

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