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European Archives of Oto-Rhino-Laryngology

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01-10-2015 | Head and Neck

Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx

Authors: Philippe Gorphe, Pierre Blanchard, Stephane Temam, François Janot

Published in: European Archives of Oto-Rhino-Laryngology | Issue 10/2015

Abstract

Disease relapses occur in up to 40 % of cases after radiotherapy (RT) for early-stage glottic laryngeal neoplasms, and the foremost remaining treatment option is salvage total laryngectomy (STL). Our objectives were to review the outcomes of patients treated with salvage surgery after RT for early-stage carcinoma of the glottic larynx and to assess prognostic factors. We retrospectively analyzed 43 patients who underwent surgery. Overall and disease-free survival rates among subgroups were calculated and compared, stratified by preoperative stage, vocal cord mobility and postoperative histopathologic data. Recurrences occurred 22.7 months after the end of RT. Surgery was STL in 33 cases (76.8 %). The main prognostic factors associated with survival rates were initial vocal cord mobility, vocal cord mobility at the diagnosis of recurrence, and changes in mobility. Vocal cord mobility is an important clinical criterion in treatment decision making for early-stage glottis carcinoma and remains important during follow-up.

Paleri V, Mehanna H, Wight RG (2010) TNM classification of malignant tumours 7th edition: what’s new for head and neck? Clin Otolaryngol Off J ENT-UK Off J Neth Soc Oto Rhino Laryngol Cerv Fac Surg 35(4):270–272. doi:10.1111/j.1749-4486.2010.02141.x

Yoo J, Lacchetti C, Hammond JA, Gilbert RW, H Neck Cancer Disease Site G (2013) The role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: a systematic review. Head Neck. doi:10.1002/hed.23504

Hartl DM (2012) Evidence-based practice: management of glottic cancer. Otolaryngol Clin North Am 45(5):1143–1161. doi:10.1016/j.otc.2012.06.014 CrossRefPubMed

Canis M, Ihler F, Martin A, Matthias C, Steiner W (2014) Transoral laser microsurgery for T1a glottic cancer: review of 404 cases. Head Neck. doi:10.1002/hed.23688

Laoufi S, Mirghani H, Janot F, Hartl DM (2013) Voice quality after treatment of T1a glottic cancer. Laryngoscope. doi:10.1002/lary.24445 PubMed

Santoro R, Meccariello G, Mannelli G, Bini B, Paiar F, Gallo O (2013) Surgical options in radiotherapy-failed early glottic cancer. Eur Arch Oto Rhino Laryngol Off J Eur Fed Oto Rhino Laryngol Soc. doi:10.1007/s00405-013-2583-0

Chen AY, Fedewa S, Zhu J (2011) Temporal trends in the treatment of early- and advanced-stage laryngeal cancer in the United States, 1985–2007. Arch Otolaryngol Head Neck Surg 137(10):1017–1024. doi:10.1001/archoto.2011.171 CrossRefPubMed

Pfister DG, Ang KK, Brizel DM, Burtness BA, Busse PM, Caudell JJ, Cmelak AJ, Colevas AD, Dunphy F, Eisele DW, Gilbert J, Gillison ML, Haddad RI, Haughey BH, Hicks WL Jr, Hitchcock YJ, Kies, Lydiatt WM, Maghami E, Martins R, McCaffrey T, Mittal BB, Pinto HA, Ridge JA, Samant S, DE Schuller, Shah JP, Spencer S, Weber RS, Wolf GT, Worden F, Yom SS, McMillian NR, Hughes M (2013) Head neck cancers, version 2.2013. Featured updates to the NCCN guidelines. J Natl Compr Canc Netw JNCCN 11(8):917–923PubMed

American Society of Clinical O, Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, Ang KK, Clayman GL, Fisher SG, Forastiere AA, Harrison LB, Lefebvre JL, Leupold N, List MA, O’Malley BO, Patel S, Posner MR, Schwartz MA, Wolf GT (2006) American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol Off J Am Soc Clin Oncol 24(22):3693–3704. doi:10.1200/JCO.2006.07.4559 CrossRef

10.

Higgins KM, Shah MD, Ogaick MJ, Enepekides D (2009) Treatment of early-stage glottic cancer: meta-analysis comparison of laser excision versus radiotherapy. J Otolaryngol Head Neck Surg 38(6):603–612PubMed

11.

Smee RI, Williams JR, Broadley K, Bridger GP (2013) Early glottic carcinoma treated by radiotherapy: defining a population for surgical salvage. Laryngoscope 123(1):171–176. doi:10.1002/lary.23663 CrossRefPubMed

12.

Pontes P, Brasil Ode O, Amorim Filho Fde S, Moraes BT, Pontes A, Caporrino Neto J (2011) Radiotherapy for early glottic cancer and salvage surgery after recurrence. Braz J Otorhinolaryngol 77(3):299–302PubMed

13.

Ganly I, Patel SG, Matsuo J, Singh B, Kraus DH, Boyle JO, Wong RJ, Shaha AR, Lee N, Shah JP (2006) Results of surgical salvage after failure of definitive radiation therapy for early-stage squamous cell carcinoma of the glottic larynx. Arch Otolaryngol Head Neck Surg 132(1):59–66. doi:10.1001/archotol.132.1.59 CrossRefPubMed

14.

Shah JP, Loree TR, Kowalski L (1990) Conservation surgery for radiation-failure carcinoma of the glottic larynx. Head Neck 12(4):326–331CrossRefPubMed

Title: Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx
Authors: Philippe Gorphe
Pierre Blanchard
Stephane Temam
François Janot
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 10/2015
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-3286-x

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Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx

Abstract

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Abstract

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