Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-04-2015 | Rhinology

Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population

Authors: Ping Wei, Wei Kou, Rong Sun, Guo-hua Hu, Di Hu, Jing Feng, Su-ling Hong, Hou-yong Kang

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2015

Abstract

Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. In this study, we investigated the relationship between polymorphisms in the IL-12R gene and AR in the Chinese Han population. A total of 543 patients with AR and 749 normal controls were genotyped for IL-12Rβ1/rs438421, IL-12Rβ2/rs3790565, rs3790567, and rs6679356 using a PCR restriction fragment length polymorphism analysis. The association study of each polymorphism of the IL-12Rβ1 and IL-12Rβ2 gene and AR showed that a significantly increased prevalence of the homozygous rs438421 GG genotype and G allele appeared in the AR patients compared with healthy controls. A significantly decreased prevalence of AG in rs438421 in AR patients is compared with healthy controls. Our research demonstrated an important association between polymorphisms in IL-12Rβ1 and AR in the Chinese Han population. A strong association between rs438421 in a single nucleotide polymorphism of IL-12Rβ1 and AR was identified.

Dykewicz MS, Hamilos DL (2011) Rhinitis and sinusitis. J Allergy Clin Immunol 125:S103–S115CrossRef

Shen J, Ke X, Hong S et al (2011) Epidemiological features of allergic rhinitis in four major cities in Western China. J HUST Med Sci 31:433–440

Gaddam SL, Priya VHS, Babu BMVS et al (2012) Association of interleukin-10 gene promoter polymorphism in allergic patients. Genet Test Mol Biomark 16:632–635CrossRef

Movahedi M, Amirzargar AA, Nasiri R et al (2013) Gene polymorphisms of Interleukin-4 in allergic rhinitis and its association with clinical phenotypes. Am J Otolaryngol 34(6):676–681CrossRefPubMed

Hu D, Hu G, Zhu J et al (2013) Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. PLoS One 8(5):e63858CrossRefPubMedCentralPubMed

Ren J, Deng Y, Xiao B et al (2013) Protective effects of exogenous surfactant protein A in allergic rhinitis: a mouse model. Ann Otol Rhinol Laryngol 122(4):240–246PubMed

Sogut A, Yilmaz O, Kirmaz C et al (2012) Regulatory-T, T-helper 1, and T-helper 2 cell differentiation in nasal mucosa of allergic rhinitis with olive pollen sensitivity. Int Arch Allergy Immunol 157(4):349–353CrossRefPubMed

Yao J, Zhou H, Xu M et al (2007) Relationship between GATA-3 and IL-12 in patients with allergic rhinitis. J Clin Otolaryngol Head Neck Surg 12(23):1087–1089

Bajoriuniene Ieva, Malakauskas Kestutis, Lavinskiene Simona et al (2012) Response of peripheral blood Th17 cells to inhaled dermatophagoides pteronyssinus in patients with allergic rhinitis and asthma. Lung 190:487–495CrossRefPubMed

10.

Jacobson NG, Szabo SJ, Weber-Nordt RM et al (1995) Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 181:1755–1762CrossRefPubMed

11.

Hoeve MA, Savage NDL, de Boer T et al (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol 36:661–670CrossRefPubMed

12.

Yamamoto K, Kobayashi H, Miura O et al (1997) Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. Cytogenet Cell Genet 77:257–258CrossRefPubMed

13.

Vignali DAA, Kuchroo VK (2012) IL-12 family cytokines: immunological playmakers. Nature Immunol 13:722–728CrossRef

14.

Van Wanrooij RL, Zwiers A, Kraal G et al (2012) Genetic variations in interleukin-12 related genes in immune-mediated diseases. J Autoimmun 39(4):359–368CrossRefPubMed

15.

Zhang XJ, Huang W, Yang S et al (2009) Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 41:205–210CrossRefPubMed

16.

Mells GF, Floyd JA, Morley KI et al (2011) Genomewide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet 43:329–332CrossRefPubMedCentralPubMed

17.

Takahashi N, Akahoshi M, Matsuda A et al (2005) Association of the IL12Rβ1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes. Hum Mol Genet 14:3149–3159CrossRefPubMed

18.

Pawankar R, Bunnag C, Khaltaev N et al (2012) Allergic rhinitis and its impact on asthma in Asia Pacific and the ARIA Update 2008. World Allergy Organ J 5:S212–S217CrossRefPubMedCentralPubMed

19.

Dreborg S, Backman A, Basomba A (1989) Skin tests used in type I allergy testing. Position Pap Allergy 44:1–59

20.

Chua AO, Wilkinson VL, Presky DH et al (1995) Cloning and characterization of a mouse IL-12 receptor-b component. J Immunol 155:4286–4294PubMed

21.

Presky DH, Yang H, Minetti LJ et al (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 93:14002–14007CrossRefPubMedCentralPubMed

22.

Nieminen K, Valovirta E, Savolainen J (2010) Clinical outcome and IL-17, IL-23, IL-27 and FOXP3 expression in peripheral blood mononuclear cells of pollen-allergic children during sublingual immunotherapy. Pediatr Allergy Immunol 21:e174–e184CrossRefPubMed

23.

Laitinen T, Ollikainen V, Lazaro C et al (2000) Association study of the chromosomal region containing the FCER2 gene suggests it has a regulatory role in atopic disorders. Am J Respir Crit Care Med 161:700–706CrossRefPubMed

24.

Michel S, Liang L, Depner M et al (2010) Unifying candidate gene and GWAS approaches in asthma. PLoS One 5(11):e13894CrossRefPubMedCentralPubMed

Title: Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population
Authors: Ping Wei
Wei Kou
Rong Sun
Guo-hua Hu
Di Hu
Jing Feng
Su-ling Hong
Hou-yong Kang
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2015
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-3145-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2015

Air, bone and soft tissue excitation of the cochlea in the presence of severe impediments to ossicle and window mobility

Erratum to: The significance of osteitis in rhinosinusitis

The clinical characteristics and treatment for sudden sensorineural hearing loss with vestibular schwannoma

When is chemotherapy in head and neck squamous cell carcinoma not indicated?

Sinonasal evaluation and treatment before liver transplantation: a retrospective review of 982 patients

Clinical and allergic sensitization characteristics of allergic rhinitis among the elderly population in Istanbul, Turkey