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European Archives of Oto-Rhino-Laryngology

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01-09-2014 | Head and Neck

Prognostic value of tumor volumetry data of routine imaging data in a head and neck cancer registry

Authors: Daniela Oemus, Johanna Inhestern, Harald Schmalenberg, Stefan Schultze-Mosgau, Hans-Joachim Mentzel, Orlando Guntinas-Lichius

Published in: European Archives of Oto-Rhino-Laryngology | Issue 9/2014

Abstract

The purpose of this study was to analyze the impact of tumor volume (TV) measurements as prognosticator for recurrence-free survival (RFS) and overall survival (OS) from data of head and neck cancer (HNC) registries. TV measurements were performed in pre-treatment computed tomography (CT) or magnetic resonance images (MRI) of 392 unselected HNC patients. TV measurements were feasible in 275 patients (70 %). Median CT TV and MRI TV were 11.43 and 10.4 cm³, respectively. The CT TV was significantly different only between T1 and T4. CT TV was significantly different only between T1 and T4 (p = 0.041). MRI TV was significantly different between T1 and T4 (p = 0.003) as well as between T2 and T4 (p = 0.002). Median follow-up was 26.1 months. Median RFS was 80.7 months. Median OS was 66.5 months. On univariate analysis, significant prognostic factors for decreased RFS were advanced T stage (p = 0.010); M1 (p = 0.001) and an MRI TV > 10.4 cm³ (p = 0.001). Significant prognostic factors for a decreased OS were advanced T stage (p = 0.001), N+ (p = 0 006), M+ (p < 0.001), tumor recurrence (p < 0.001), CT TV (p = 0.005), and MRI TV (p = 0.012). On multivariate analysis for RFS, MRI TV was the best independent prognosticator (p = 0.003). On multivariate analysis for OS, T stage (p = 0.006) was a better prognosticator than CT or MRI TV. Using CT and MRI data sets of an unselected series of HNC patients in a cancer registry, TV measurements were not feasible in all patients. MRT TV was a powerful prognosticator for RFS.

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Title: Prognostic value of tumor volumetry data of routine imaging data in a head and neck cancer registry
Authors: Daniela Oemus
Johanna Inhestern
Harald Schmalenberg
Stefan Schultze-Mosgau
Hans-Joachim Mentzel
Orlando Guntinas-Lichius
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 9/2014
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2800-x

At a glance: The STEP trials

Springer Medicine

Prognostic value of tumor volumetry data of routine imaging data in a head and neck cancer registry

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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