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European Archives of Oto-Rhino-Laryngology

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01-04-2014 | Miscellaneous

Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation

Authors: Qi-Chang Lin, Li-Da Chen, Yao-Hua Yu, Kai-Xiong Liu, Shao-Yong Gao

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2014

Abstract

Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular morbidity and mortality. However, the underlying mechanism is unclear. In this cross-sectional study, we investigated the influence of OSA on metabolic syndrome (MetS) and inflammation, which were considered as cardiovascular risks. A total of 144 consecutive male patients who underwent standard polysomnography were enrolled. Fasting blood samples were obtained from all patients for glucose, high-sensitivity C-reactive protein (hs-CRP) and lipids measurement. A metabolic score was established as the total number of the positive diagnostic criteria of metabolic syndrome for each patient. Systolic blood pressure, diastolic blood pressure, fasting glucose, hs-CRP and metabolic score significantly increased with the aggravation of OSA severity. Metabolic score increased from 1.74 ± 1.20 to 2.89 ± 0.99 with OSA severity (p = 0.000). hs-CRP increased from 0.68 (0.43–1.10) to 1.44 (0.62–4.02) mg/L with OSA severity (p = 0.002). After adjustment for confounders, apnea–hypopnea index and body mass index (BMI) were the major contributing factors for metabolic score (β = 0.257, p = 0.003 and β = 0.344, p = 0.000, respectively), lowest O₂ saturation and BMI were the independent predictors of hs-CRP (β = −0.255, p = 0.003 and β = 0.295, p = 0.001, respectively). OSA is independently associated with sum of metabolic components and hs-CRP.

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Title: Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation
Authors: Qi-Chang Lin
Li-Da Chen
Yao-Hua Yu
Kai-Xiong Liu
Shao-Yong Gao
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2014
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2669-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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