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European Archives of Oto-Rhino-Laryngology

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Open Access 01-02-2013 | Head and Neck

Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?

Authors: Gyorgy B. Halmos, Tom P. van der Laan, Bettien M. van Hemel, Frederik G. Dikkers, Lorian Slagter-Menkema, Bernard F. A. M. van der Laan, Ed Schuuring

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2013

Abstract

The purpose of this study was to detect human papillomavirus (HPV) infection in laryngeal neuroendocrine carcinoma (LNEC) and to explore the possible relationship between HPV-induced malignant transformation and prognosis in LNEC. Ten cases of LNEC from a tertiary referral hospital were retrospectively analyzed. Clinical data were subtracted from patients’ files. Pretreatment biopsy material was tested for the presence of HPV6, 11, 16, and 18 using a PCR-based detection method. Immunohistochemical staining was performed for Ki-67, p16^INK4A, and p53 expression. All cases were negative for the low-risk HPV types HPV6 and HPV11 that are associated with laryngeal papillomatosis. High-risk HPV was detected in two cases; an atypical carcinoid was positive for HPV16 and a large-cell neuroendocrine carcinoma for HPV18. Both HPV-positive tumors had a high Ki-67 labeling index. Two of the four cases with a good response to therapy were hrHPV-positive (both HPV DNA positive) compared with none of the five poor responders. Our findings show that HPV may play a role in the pathogenesis of LNEC. The relationship between HPV, improved prognosis and good response to therapy for squamous cell carcinoma of the head and neck may also be true for a subset of LNEC.

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Title: Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?
Authors: Gyorgy B. Halmos
Tom P. van der Laan
Bettien M. van Hemel
Frederik G. Dikkers
Lorian Slagter-Menkema
Bernard F. A. M. van der Laan
Ed Schuuring
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2013
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-012-2075-7

At a glance: The STEP trials

Springer Medicine

Is human papillomavirus involved in laryngeal neuroendocrine carcinoma?

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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