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European Archives of Oto-Rhino-Laryngology

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Open Access 01-02-2012 | Review Article

Phytotherapeutic and naturopathic adjuvant therapies in otorhinolaryngology

Author: Raphael Richard Ciuman

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2012

Abstract

Phytotherapeutic pharmaceuticals and herbal medicinal products with its roots in classical phytotherapeutic medicine have a well-established role in otolaryngological therapy, especially for diseases of the upper airways and acute and chronic infections. A thorough selection and application could mean huge benefit for the patient, in particular in cases with contraindications, chemo- and antibiotic resistance or patient request. Besides, it might spare other medications. Phytotherapeutic pharmaceuticals must fulfil the same criteria of quality, effectiveness and harmlessness of evidence-based medicine like chemical pharmaceuticals, although they are often prescribed due to its well established or traditional based use. This review focuses on phytotherapeutic therapies well established within the European Community for otolaryngologic disease patterns by referring to clinical studies or meta-analysis.

Fox N (1927) Effect of camphor, eucalyptol, and menthol on the vascular state of the mucous membrane. Arch Otolaryngol Head Neck Surg 6:112–122CrossRef

Behrbohm H, Kaschke O, Sydow K (1995) Effect of phytogenic secretolytic drug Gelomyrtol forte on mucociliary clearance of the maxillary sinus. Laryngorhinootologie 74:733–737PubMedCrossRef

Federspil P, Wulkow R, Zimmermann T (1997) Effects of standardized myrtol in therapy of acute sinusitis-results of a double-blind, randomized multicenter study compared with placebo. Laryngorhinootologie 76:23–27PubMedCrossRef

Melzer J, Saller R, Schapowal A, Brignoli R (2006) Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forschende Komplementärmedizin 13:78–87 (German)PubMedCrossRef

Ismail C, Wiesel A, März RW, Queisser-Luft A (2002) Surveillance study of Sinupret in comparison with data of the Mainz birth registry. Arch Gynecol Obstet 267:196–201PubMed

Meister R, Wittig T, Beuscher N, deMey C (1999) Efficacy and tolerability of myrtol standardized in long term treatment of chronic bronchitis. A double-blind, placebo-controlled study. Study group investigators. Arzneimittelforschung 49:351–358 (German)PubMed

Ernst E, März RW, Sieder C (1997) Acute bronchitis: effectiveness of Sinupret. Comparative study with common expectorants in 3187 patients. Fortschr Med 115:52–53 (German)PubMed

März RW, Ismail C, Popp MA (1999) Profile and effectiveness of a phytogenic combination preparation for treatment of sinusitis. Wien Med Wochenschr 149:202–208 (German)PubMed

Matthys H, deMey C, Carls C, Geib A, Wittig T (2000) Efficacy and tolerability of myrtol standardized in acute bronchitis. A multi-centre, randomised, double-blind, placebo-controlled parallel group clinical trial vs. cefuroxime and ambroxol. Arzneimittelforschung 50:700–711 (German)PubMed

10.

Schapowal A (2002) Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 324:144–146PubMedCrossRef

11.

Schapowal A (2004) Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol Head Neck Surg 130:1381–1386PubMedCrossRef

12.

Guo R, Pittler MH, Ernst E (2007) Herbal medicines tor the treatment of allergic rhinitis: a systematic review. Ann Asthma Allergy Immunol 99:483–495CrossRef

13.

Chi H, Chiu NC, Li WC, Huang FY (2003) Etiology of acute pharyngitis in children: is antibiotic therapy needed. J Microbiol Immunol Infect 36:26–30PubMed

14.

Eposito S, Blasi F, Bosis S (2004) Aetiology of acute pharyngitis: the role of atypical bacteria. J Med Microbiol 53:645–651CrossRef

15.

Gerber MA (2005) Diagnosis and treatment of pharyngitis in children. Pediatr Clin North Am 52:729–747PubMedCrossRef

16.

Berger T (2008) Tolerability and efficacy of a herbal combination preparation in children and adolescents with recurrent infections of the upper respiratory tract. MMW Fortschr Med 150:85–90 (German)PubMed

17.

Conrad A, Kolberg T, Engels I, Frank U (2006) In vitro study to evaluate the antibacterial activity of a combination of the haulm of nasturtium (Tropaeoli majoris herba) and of the roots of horseradish (Armoraciae rusticanae radix). Arzneimittelforschung 56:842–849 (German)PubMed

18.

Goos KH, Albrecht U, Schneider B (2006) Efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in comparison with other treatments in the daily practice/results of a prospective cohort study. Arzneimittelforschung 56:249–257 (German)PubMed

19.

Goos KH, Albrecht U, Schneider B (2007) On-going investigations on efficacy and safety profile of a herbal drug containing nasturtium herb and horseradish root in acute sinusitis, acute bronchitis and acute urinary tract infection in children in comparison with other antibiotic treatments. Arzneimittelforschung 57:238–246 (German)PubMed

20.

März RW, Kemper F (2002) Willow bark extract-effects and effectiveness. Status of current knowledge regarding pharmacology, toxicology and clinical aspects. Wien Med Wochenschr 152:354–359 (German)PubMedCrossRef

21.

Zakay-Rones Z, Thom E, Wollan T, Wadstein J (2004) Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res 32:132–140PubMed

22.

Matthys H, Eisebitt R, Seith B, Heger M (2003) Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Phytomedicine 10:7–17PubMedCrossRef

23.

Matthys H, Kamin W, Funk P, Heger M (2007) Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. Phytomedicine 14(Suppl 6):69–73PubMedCrossRef

24.

Conrad A, Kolodziej H, Schulz V (2007) Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety. Wien Med Wochenschr 157:331–336 (German)PubMedCrossRef

25.

Kolodziej H, Schulz V (2003) Umckaloabo. Deutsche Apotheker Zeitung 143:55–64 (German)

26.

Beer AM, Loew D (2008) Medical plants for infections of the upper and lower airway tract: practical recommendations. MMW Fortschr Med 150:29–33 (German)PubMed

27.

Marzian O (2007) Treatment of acute bronchitis in children and adolescents. Non interventional postmarketing surveillance study confirms the benefit and safety of a syrup made of extracts from thyme and ivy leaves. MMW Fortschr Med 149:69–74 (German)PubMed

28.

Schilcher H, Kammerer S, Wegener T (2007) Praxisleitfaden phytotherapie. Urban und Fischer, München (German)

29.

Bolbot Y, Prokhorov E, Mokia S, Yurtseva A (2004) Comparing the efficacy and safety of high-concentrate ivy leaves extract and acetylcysteine for treatment of children with acute bronchitis. Drugs of Ukraine 11

30.

Ernst E, März R, Sieder C (1997) A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine 1:287–293CrossRef

31.

Ismail C, Willer G, Steindl H (2003) Bronchipret in acute bronchitis. Schweizerische Zeitschrift für Ganzheitsmedizin 15:171–175 (German)

32.

Abe J, Hosokawa H, Sawada Y, Matsumura K, Kobayashi S (2006) Ca²⁺-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8. Neurosci Lett 397:140–144PubMedCrossRef

33.

Mohrig A, Alken RG (1996) Melissa extract in comparison to acyclovir. Pharmazeutische Rundschau 38:25–26 (German)

34.

Wölbling RH, Leonhardt K (1994) Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1:25–31CrossRef

35.

Köhler K (1997) Extract from Melissa officinalis in herpes simplex. Effectivity against placebo proofed again. Allgemeinarzt 19:1853–1854 (German)

36.

Buechi S (2005) Sage leaves and pieplant roots vs acyclovir in herbes labialis. Zeitschrift für Phytotherapie 26:275–277 (German)CrossRef

37.

Vynograd N, Vynograd I, Sosnowski Z (2000) A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine 7:1–6PubMedCrossRef

38.

Koch C, Reiching J, Schneele J, Schnitzler P (2008) Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine 15:71–78PubMedCrossRef

39.

Nolkemper S, Reichling J, Stintzing FC (2006) Antiviral effect of aqueous extracts from species of the Lamiaceae family against herpes simplex virus type 1 and type 2 in vitro. Plant Med 72:1378–1382CrossRef

40.

Schnitzler P, Schön K, Reichling J (2001) Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. Die Pharmazie 56:343–347 (German)PubMed

41.

Babaee N, Mansourian A, Momen-Haravi F, Moghadamnia A, Momen-Beitollahi J (2010) The efficacy of paste containing Myrtus communis (Myrtle) in the management in recurrent aphthous stomatitis: a randomized controlled trial. Clin Oral Investig 14:65–70PubMedCrossRef

42.

Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N (2007) The effect of bee propolis in recurrent aphthous stomatitis. Clin Oral Investig 11:143–147PubMedCrossRef

43.

Braga PC, Alfieri M, Culici M, Dalsasso M (2007) Inhibitory activity of thymol against the formation and viability of Candida albicans hyphae. Mycoses 50:502–506PubMedCrossRef

44.

Giordani R, Regli P, Kaloustian J, Mikail C, Abou L, Portugal H (2004) Antifungal effect of various essential oils against Candida albicans. Potentiation of antifungal action of amphotericin B by essential oils from thymus vulgaris. Phytother Res 18:990–995PubMedCrossRef

45.

Warnke PH, Sherry E, Russo PA, Acil Y, Wiltfang J, Sivananthan S, Sprengel M, Roldan JC, Schubert S, Bredee JP, Springer IN (2006) Antibacterial essential oils in malodorous cancer patients: clinical observations in 30 patients. Phytomedicine 13:463–467PubMedCrossRef

46.

Braga PC, Sasso MD, Culici M, Alfieri M (2007) Eugenol and thymol alone or in combination induce alterations in the envelope of Candida albicans. Fitoterapia 78:396–400PubMedCrossRef

47.

Bulut Y, Güven M, Otlu B, yenisehirli G, Aladag I, Eyibilen A, Dogru S (2007) Acute otitis media and respiratory viruses. Eur J Pediatr 166:223–228PubMedCrossRef

48.

Damoiseaux RA, Van Balen FA, Hoes AW, deMelker RA (1998) Antibiotic treatment of acute otitis media in children under two years of age: evidence based? Br J Gen Pract 48:1861–1864PubMed

49.

Glasziou PP, DelMar CB, Sanders SL, Hayem M (2004) Antibiotics for acute otitis media in children. Cochrane Database Syst Rev 1:CD000219PubMed

50.

McCormick DP, Chonmaitree T, Pittman C, Saeed K, Friedman NR, Uchida T, Baldwin CD (2005) Nonsevere acute otitis media: a clinical trial comparing outcomes of watchful waiting versus immediate antibiotic treatment. Pediatrics 115:1455–1465PubMedCrossRef

51.

Sarrell EM, Mandelberg A, Cohen HA (2001) Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media. Arch Pediatr Adolesc Med 155:796–799PubMed

52.

Sarrell EM, Cohen HA, Kahan E (2003) Naturopathic treatment for ear pain in children. Pediatrics 111:574–579CrossRef

53.

Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ (1997) Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 112:1448–1456PubMedCrossRef

54.

Bespalov VG, Alexandrov VA, Limarenko AY (2001) Chemoprevention of mammary, cervix and nervous system carcinogenesis in animals using cultured Panax ginseng drugs and preliminary clinical trials in patients with precancerous lesions of the esophagus and endometrium. J Korean Med Sci 16:42–53

55.

Shin HR, Kim JY, Yun TK, Morgan G, Vainio H (2000) The cancer preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 11:565–576PubMedCrossRef

56.

Sehn E, Hernandes L, Franco SL, Goncalves CC, Baesso ML (2009) Dynamics of reepithelialisation and penetration rate of a bee propolis formulation during cutaneous wound healing. Anal Chim Acta 635:115–120PubMedCrossRef

57.

Bardy J, Slevin NJ, Mais KL, Molasiottis A (2008) A systematic review of honey uses and its potential value with oncologic care. J Clin Nurs 17:2661–2664CrossRef

58.

Jull AB, Rodgers A, Walker N (2008) Honey as a topical treatment for wounds. Cochrane Database Syst Rev 4:CD005083PubMed

59.

Robson V, Dodd S, Thomas S (2009) Standardized antibacterial honey (Medihoney) with standard therapy in wound care: randomized clinical trial. J Adv Nurs 65:565–575PubMedCrossRef

60.

Bialoszewski D, Kowalewski M (2003) Superficially, longer, intermittent ozone therapy in the treatment of the chronic, infected wounds. Ortop Traumatol Rehabil 5:652–658 (Polish)PubMed

61.

Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, Park YM (2009) Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci 24:368–374PubMedCrossRef

62.

Skomro P, Opalko K, Gadomska-Krasny J, Lietz-Kijak D, Perzanowska-Stefanska M (2005) Ozone therapy with the Ozonytrone apparatus. Ann Acad Med Stetin 52:39–42 (Polish)

63.

Valacchi G, Fortino V, Bocci V (2005) The dual action of ozone on the skin. Br J Dermatol 153:1096–1100PubMedCrossRef

64.

Warnke PH, Becker ST, Podschun R, Sivananthan S, Springer IN, Russo PA, Wiltfang J, Fickenscher H, Sherry E (2009) The battle against multi-resistant strains: renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. J Cranio-maxillo-fac Surg 37:392–397

65.

Chandran PK, Kuttan R (2008) Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanisms, and granuloma formation during thermal burns. J Clin Biochem Nutr 43:58–64PubMedCrossRef

66.

Duran V, Matic M, Jovanovc M, Mimica N, Gajinov Z, Poljacki M, Boza P (2005) Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React 27:101–106PubMed

67.

Grimme H, Augustin M (1999) Phytotherapy in chronic dermatoses and wounds: what is evidence? Forschende Komplementärmedizin 5(Suppl 2):5–8 (German)CrossRef

68.

McQuestion M (2006) Evidence-based skin care management in radiation therapy. Semin Oncol Nurs 22:163–173PubMedCrossRef

69.

Pommier P, Gomez F, Sunyach MP, D’Hombres A, Carries C, Montbarbon X (2004) Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 22:1447–1453PubMedCrossRef

70.

Melchart D, Linde K, Fischer P, Kaesmayr J (2000) Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev 2:CD000530PubMed

71.

Schoop R, Klein P, Suter A, Johnston SL (2006) Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther 28:174–183PubMedCrossRef

72.

Chang YS, Lee JY, Kim CW (1978) The effect of ginsenoide-triol on the postoperative recovery in gynecological patients. In: Proceedings of the second international Ginseng symposium, pp 79–84

73.

Careddu P (1999) Motion sickness in children: results of a double-blind study with ginger (Zintona) and dimenhydrinate. Healthnotes Rev Complement Integr Med 6:102–107

74.

Ribenfeld D, Borzone L (1999) Randomized double-blind study comparing ginger (Zintona) with dimenhydrinate in motion sickness. Healthnotes Rev Complement Integr Med 6:98–101

75.

Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C (2006) The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol 194:95–99PubMedCrossRef

76.

Chittumma P, Kaewkiattikun K, Wiriyasiriwach B (2007) Comparison of the effectiveness of ginger and vitamin B6 for the treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thailand 90:15–20

77.

Ernst E, Pittler MH (2000) Efficacy for ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anesth 84:367–371

78.

Ozgoli G, Goli M, Simbar M (2009) Effects on ginger capsules on pregnancy, nausea, and vomiting. J Altern Complement Med 15:243–246PubMedCrossRef

79.

Smith C, Crowther C, Willson K, Hotham N, McMillian V (2004) A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 103:639–645PubMedCrossRef

80.

White B (2007) Ginger: an overview. Am Fam Phys 75:1689–1691

81.

Clostre F (1999) Ginkgo biloba extract (EGb 761) State of knowledge in the dawn of the year 2000. Ann Parma Francaises 57(Suppl 1):8–88 (French)

82.

Hamann K (2007) Special Gingko extract in cases of vertigo: a systematic review of randomised, double-blind, placebo-controlled clinical examinations. HNO 55:258–263 (German)PubMedCrossRef

Title: Phytotherapeutic and naturopathic adjuvant therapies in otorhinolaryngology
Author: Raphael Richard Ciuman
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2012
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-011-1755-z

At a glance: The STEP trials

Springer Medicine

Phytotherapeutic and naturopathic adjuvant therapies in otorhinolaryngology

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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