Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 5/2010

01-05-2010 | Head and Neck

Paratracheal lymph node dissection does not negatively affect thyroid dysfunction in patients undergoing laryngectomy

Authors: Annalisa M. Lo Galbo, Remco de Bree, Dirk J. Kuik, Paul Lips, C. René Leemans

Published in: European Archives of Oto-Rhino-Laryngology | Issue 5/2010

Login to get access

Abstract

The aim of this retrospective study was to evaluate the prognostic significance of paratracheal lymph node dissection including hemithyroidectomy for the development of hypo(para)thyroidism. From 1990 to 2004, 169 patients with a carcinoma of the larynx or hypopharynx who underwent paratracheal lymph node dissection were selected. Data of 137 patients (23 women, 114 men) were analyzed. Hundred patients were tested on thyroid function. Patient, tumor and treatment characteristics were noted including age, gender, site, TNM stage and details of surgery, radiotherapy and chemotherapy. Seventy percent of the tested patients had hypothyroidism (36% clinical, 34% subclinical); 33% had hypoparathyroidism. All patients with hypo(para)thyroidism underwent various lymph node treatment modalities. For the various treatment combinations, no increase of hypo(para)thyroidism was found if a bilateral paratracheal lymph node dissection was performed. The incidence of hypo(para)thyroidism after laryngectomy in combination with hemithyroidectomy, neck dissection and paratracheal lymph node dissection is high. An additional risk of paratracheal dissection for the development of hypo(para)thyroidism could not be shown.
Literature
1.
Leon X, Gras JR, Perez A et al (2002) Hypothyroidism in patients treated with total laryngectomy. A multivariate study. Eur Arch Otorhinolaryngol 259:193–196CrossRefPubMed
2.
Mercado G, Adelstein DJ, Saxton JP et al (2001) Hypothyroidism: a frequent event after radiotherapy with chemotherapy for patients with head and neck carcinoma. Cancer 92:2892–2897CrossRefPubMed
3.
Ho AC, Ho WK, Lam PK et al (2008) Thyroid dysfunction in laryngectomies—10 years after treatment. Head Neck 30:336–340CrossRefPubMed
4.
Lo Galbo AM, de Bree R, Kuik DJ et al (2007) The prevalence of hypothyroidism after treatment for laryngeal and hypopharyngeal carcinomas: are autoantibodies of influence? Acta Otolaryngol 127:312–317CrossRefPubMed
5.
Gulseren S, Gulseren L, Hekimsoy Z et al (2006) Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction. Arch of Med Res 37:133–139CrossRef
6.
Jaeschke R, Guyatt G, Cook D et al (1994) Spectrum of quality of life impairment in hypothyroidism. Qual of Life Res 3:323–327CrossRef
7.
Geminiani M, Aimoni C, Scanelli G et al (2007) Parathyroid function study in patients submitted to laryngeal surgery for squamous cell carcinoma. Acta Otorhinolaryngol Ital 27:123–125PubMed
8.
Bohrer T, Hagemeister M, Elert O (2007) A clinical chameleon: postoperative hypoparathyroidism. Langenbecks Arch Surg 392:423–426CrossRefPubMed
9.
Lallemant B, Reynaud C, Alovisetti C et al (2007) Updated definition of level VI lymphnode classification in the neck. Acta Otolaryngol 127:318–322CrossRefPubMed
10.
Plaat RE, de Bree R, Kuik DJ et al (2005) Prognostic importance of paratracheal lymph node metastases. Laryngoscope 115:894–898CrossRefPubMed
11.
Timon CV, Toner M, Conlon BJ et al (2003) Paratracheal lymph node involvement in advanced cancer of the larynx, hypopharynx, and cervical esophagus. Laryngoscope 113:1595–1599CrossRefPubMed
12.
Ferlito A, Silver CE, Rinaldo A et al (2000) Surgical treatment of the neck in cancer of the larynx. ORL J Otorhinolaryngol Relat Spec 62:217–225PubMed
13.
Fagan JJ, Kaye PV (1997) Management of the thyroid gland with laryngectomy for cT3 glottic carcinomas. Clin Otolaryngol Allied Sci 22:7–12CrossRefPubMed
14.
Pallotti F, Seregni E, Ferrari L et al (2003) Diagnostic and therapeutic aspects of iatrogenic hypoparathyroidism. Tumori 89:547–549PubMed
15.
Thorp MA, Levitt NS, Mortimore S et al (1999) Parathyroid and thyroid function five years after treatment of laryngeal and hypopharyngeal carcinoma. Clin Otolaryngol Allied Sci 24:104–108CrossRefPubMed
Metadata
Title
Paratracheal lymph node dissection does not negatively affect thyroid dysfunction in patients undergoing laryngectomy
Authors
Annalisa M. Lo Galbo
Remco de Bree
Dirk J. Kuik
Paul Lips
C. René Leemans
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 5/2010
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-009-1152-z

Other articles of this Issue 5/2010

European Archives of Oto-Rhino-Laryngology 5/2010 Go to the issue

Otology

Modified intratympanic treatment for idiopathic sudden sensorineural hearing loss

Head and Neck

Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland

Rhinology

The maxillary sinus after total laryngectomy: an electron microscopic study

Laryngology

Results of vocal rehabilitation using tracheoesophageal voice prosthesis after total laryngectomy and their predictive factors

Otology

Tympanosclerosis and our surgical results

Letter to the Editor

Critical analysis of the laryngopharyngeal reflux literature