Top

European Archives of Oto-Rhino-Laryngology

Published in:

01-10-2009 | Review Article

Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma

Authors: Jarosław Markowski, Tomasz Tyszkiewicz, Michał Jarząb, Małgorzata Oczko-Wojciechowska, Tatiana Gierek, Małgorzata Witkowska, Jarosław Paluch, Małgorzata Kowalska, Zbigniew Wygoda, Dariusz Lange, Barbara Jarząb

Published in: European Archives of Oto-Rhino-Laryngology | Issue 10/2009

Abstract

The assessment of gene expression profile in laryngeal cancer allows implementation of molecular biology methods in diagnostics, as well as in prognosticating the course of disease, thus allowing taking most optimal decisions as regards the method of treatment, scope of surgical procedure, or the necessity of adding complementary radiotherapy. The aim of the project was to analyze the gene expression profile in laryngeal cancer using oligonucleotide microarrays, having in mind searching new molecular markers for that carcinoma. The study comprised a group of 43 patients (38 males and 5 females) suffering from squamous cell laryngeal carcinoma, diagnosed and surgically treated in the years 2005–2007 in the ENT Department of the Silesian Medical University in Katowice, Poland. RNA was isolated from frozen tissue fragments, with the use of columns RNeasy Midi and Mini Kit (Qiagen). For the examination of gene expression profile, oligonucleotide microarrays of high density were used, provided by Affymetrix (U 133 2.0 PLUS) containing over 54,000 probes for over 47,000 transcripts. Four genes previously not examined in that respect in laryngeal carcinoma, occurred to be good markers of the neoplasm. They are: metal-proteinase ADAM12, cyclin-dependent kinase 2–CDK2, kinesin 14–KIF14, suppressor 1 of checkpoint–CHES1. The analysis of gene expression profile allows, in laryngeal carcinoma, to point out to new genes, which in future may become molecular markers of the carcinoma.

Dysvik B, Vasstrand EN, Lovlie R, Elgindi OA, Kross KW, Aarstad HJ et al (2006) Gene expression profiles of head and neck carcinomas from Sudanese and Norwegian patients reveal common biological pathways regardless of race and lifestyle. Clin Cancer Res 12(4):1109–1120PubMedCrossRef

Perez-Ordonez B, Beauchemin M, Jordan RC (2006) Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol 59(5):445–453PubMedCrossRef

Pyeon D, Newton MA, Lambert PF, den Boon JA, Sengupta S, Marsit CJ et al (2007) Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res 67(10):4605–4619PubMedCrossRef

Lee TL, Yang XP, Yan B, Friedman J, Duggal P, Bagain L et al (2007) A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status. Clin Cancer Res 13(19):5680–5691PubMedCrossRef

Yan B, Yang X, Lee TL, Friedman J, Tang J, Van WC et al (2007) Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinoma. Genome Biol 8(5):R78PubMedCrossRef

Chung CH, Parker JS, Ely K, Carter J, Yi Y, Murphy BA et al (2006) Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma. Cancer Res 66(16):8210–8218PubMedCrossRef

Ferris RL, Grandis JR (2007) NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma. Clin Cancer Res 13(19):5663–5664PubMedCrossRef

Akervall J (2006) Genomic screening of head and neck cancer and its implications for therapy planning. Eur Arch Otorhinolaryngol 263(4):297–304PubMedCrossRef

Belbin TJ, Singh B, Smith RV, Socci ND, Wreesmann VB, Sanchez-Carbayo M et al (2005) Molecular profiling of tumor progression in head and neck cancer. Arch Otolaryngol Head Neck Surg 131(1):10–18PubMedCrossRef

10.

Jarvinen AK, Autio R, Haapa-Paananen S, Wolf M, Saarela M, Grenman R et al (2006) Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses. Oncogene 25(52):6997–7008PubMedCrossRef

11.

Gottschlich S, Ambrosch P, Cordes C, Gorogh T, Schreiber S, Hasler R (2006) Gene expression profiling of head and neck squamous cell carcinoma using cDNA microarrays. Int J Oncol 29(3):605–613PubMed

12.

Al Moustafa AE, Alaoui-Jamali MA, Batist G, Hernandez-Perez M, Serruya C, Alpert L et al (2002) Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells. Oncogene 21(17):2634–2640PubMedCrossRef

13.

Choi P, Chen C (2005) Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma. Cancer 104(6):1113–1128PubMedCrossRef

14.

Thomas GR, Nadiminti H, Regalado J (2005) Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. Int J Exp Pathol 86(6):347–363PubMedCrossRef

15.

Hussein MR, Cullen K (2001) Molecular biomarkers in HNSCC: prognostic and therapeutic implications. Expert Rev Anticancer Ther 1(1):116–124PubMedCrossRef

16.

Ziober AF, Patel KR, Alawi F, Gimotty P, Weber RS, Feldman MM et al (2006) Identification of a gene signature for rapid screening of oral squamous cell carcinoma. Clin Cancer Res 12(20 Pt 1):5960–5971PubMedCrossRef

17.

Markowski J, Oczko-Wojciechowska M, Gierek T, Jarzab M, Paluch J, Kowalska M, Wygoda Z, Pfeifer A, Tyszkiewicz T, Jarzab B, Niedzielska I, Borgiel-Marek H (2009) Gene expression profile analysis in laryngeal cancer by high-density oligonucleotide microarrays. J Physiol Pharmacol 60(suppl. 1):57–63PubMed

18.

Wu E, Croucher PI, McKie N (1997) Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies. Biochem Biophys Res Commun 235(2):437–442PubMedCrossRef

19.

Carl-McGrath S, Lendeckel U, Ebert M, Roessner A, Rocken C (2005) The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol 26(1):17–24PubMed

20.

Dyczynska E, Syta E, Sun D, Zolkiewska A (2008) Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein. Int J Cancer 122(11):2634–2640PubMedCrossRef

21.

Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T et al (2004) ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol 165(5):1743–1753PubMed

22.

Chang JT, Wang HM, Chang KW, Chen WH, Wen MC, Hsu YM et al (2005) Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1. Int J Cancer 114(6):942–949PubMedCrossRef

23.

Pehlivan D, Gunduz E, Gunduz M, Nagatsuka H, Beder LB, Cengiz B et al (2008) Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas. J Cancer Res Clin Oncol 134(12):1267–1276PubMedCrossRef

24.

Scott KL, Plon SE (2005) CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. Gene 359:119–126PubMedCrossRef

25.

Corson TW, Huang A, Tsao MS, Gallie BL (2005) KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Oncogene 24(30):4741–4753PubMedCrossRef

26.

Corson TW, Gallie BL (2006) KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. Int J Cancer 119(5):1088–1094PubMedCrossRef

27.

Corson TW, Zhu CQ, Lau SK, Shepherd FA, Tsao MS, Gallie BL (2007) KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer. Clin Cancer Res 13(11):3229–3234PubMedCrossRef

28.

Yilmaz T, Hosal AS, Gedikoglu G, Kaya S (1999) Prognostic significance of histopathological parameters in cancer of the larynx. Eur Arch Otorhinolaryngol 256(3):139–144PubMedCrossRef

Title: Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma
Authors: Jarosław Markowski
Tomasz Tyszkiewicz
Michał Jarząb
Małgorzata Oczko-Wojciechowska
Tatiana Gierek
Małgorzata Witkowska
Jarosław Paluch
Małgorzata Kowalska
Zbigniew Wygoda
Dariusz Lange
Barbara Jarząb
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 10/2009
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-009-1019-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 10/2009

Application methods of local anaesthetic infiltrations for postoperative pain relief in tonsillectomy: a prospective, randomised, double-blind, clinical trial

The origin of bronchial foreign bodies: a retrospective study and literature review

The effectiveness of gabapentin on post-tonsillectomy pain control

Over-injection of autologus fat in the vocal fold: how to remove the excess?

Isolated otitis media with effusion in adults: is biopsy of the postnasal space required?

Static and dynamic postural control before and after cochlear implantation in adult patients