Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 7/2009

01-07-2009 | Rhinology

Clinical significance of eosinophilic cationic protein levels in nasal secretions of patients with nasal polyposis

Authors: Dong-Il Sun, Young-Hoon Joo, Hyeon-Jin Auo, Jun-Myung Kang

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2009

Login to get access

Abstract

Nasal polyps are characterized by eosinophilic infiltration, and frequently coexist with asthma, aspirin intolerance and allergy. Eosinophilic cationic protein (ECP) is a specific eosinophil granule protein released upon activation of eosinophils. We investigated the ECP levels in nasal secretions of patients with nasal polyposis (NP) in order to correlate them with disease severity and associated diseases and to compare ECP levels between patients with and without recurrence of NP after surgical treatment. A total of 78 patients who had surgery for NP were followed up for a minimum of 18 months. The presence of asthma, allergies or aspirin intolerance was noted. Nasal secretions were obtained 1 day before the surgery and during the follow-up period after surgery. Immunoassays were used to quantify ECP in nasal secretions and serum and interleukin (IL)-5 in nasal secretions. ECP levels in nasal secretions were higher in patients with asthma or aspirin intolerance than in patients without asthma or aspirin intolerance, while no significant differences were found between allergic and non-allergic patients. ECP levels in nasal secretions correlated significantly with IL-5 levels in nasal secretions, the degree of tissue eosinophilia and computed tomographic (CT) scores. In total, 30 patients (38%) developed recurrent NP during the follow-up period. Preoperative ECP and IL-5 levels in nasal secretions were significantly higher in patients with recurrence compared to patients without recurrence. During the follow-up period, patients without recurrence demonstrated a significant reduction in the ECP levels in nasal secretions, whereas there was no significant reduction in the ECP levels of patients with recurrence. The results of this study provide evidence that ECP levels in nasal secretions of patients with NP correlate with the presence of asthma or aspirin intolerance and severity of NP determined by CT scores.
Literature
1.
Kramer MF, Rasp G (1999) Nasal polyposis: eosinophils and interleukin-5. Allergy 547:669–680CrossRef
2.
Fokkens W, Lund V, Mullol J, European Position Paper on Rhinosinusitis and Nasal Polyps Group (2007) EP3OS 2007: European position paper on rhinosinusitis, nasal polyps. Rhinology 45(Suppl 20):1–139
3.
Simon HU, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K (1997) Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1588:3902–3908
4.
Ediger D, Sin BA, Heper A, Anadolu Y, Misirligil Z (2005) Airway inflammation in nasal polyposis: immunopathological aspects of relation to asthma. Clin Exp Allergy 353:319–326CrossRef
5.
Bhattacharyya N, Vyas DK, Fechner FP, Gliklich RE, Metson R (2001) Tissue eosinophilia in chronic sinusitis: quantification techniques. Arch Otolaryngol Head Neck Surg 1279:1102–1105
6.
Elwany S, Bassyouni M, Morad F (2002) Some risk factors for refractory chronic sinusitis: an immunohistochemical and electron microscopic study. J Laryngol Otol 116:112–115PubMedCrossRef
7.
Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F (1998) Serum eosinophil cationic protein as a marker of eosinophilic inflammation in asthma. Clin Exp Allergy 282:233–240CrossRef
8.
Rasp G, Thomas PA, Bujia J (1994) Eosinophil inflammation of the nasal mucosa in allergic and non-allergic rhinitis measured by eosinophil cationic protein levels in native nasal fluid and serum. Clin Exp Allergy 2412:1151–1156
9.
Di Lorenzo G, Drago A, Esposito Pellitteri M, Candore G, Colombo A, Gervasi F, Pacor ML, Purello D’Ambrosio F, Caruso C (2001) Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol 1252:164–175CrossRef
10.
Kramer MF, Burow G, Pfrogner E, Rasp G (2004) In vitro diagnosis of chronic nasal inflammation. Clin Exp Allergy 347:1086–1092CrossRef
11.
Kramer MF, Ostertag P, Pfrogner E, Rasp G (2000) Nasal interleukin-5, immunoglobulin E, eosinophilic cationic protein, and soluble intercellular adhesion molecule-1 in chronic sinusitis, allergic rhinitis, and nasal polyposis. Laryngoscope 1106:1056–1062CrossRef
12.
Bachert C, Hormann K, Mosges R, Rasp G, Riechelmann H, Muller R, Luckhaupt H, Stuck BA, Rudack C (2003) An update on the diagnosis and treatment of sinusitis and nasal polyposis. Allergy 583:176–191CrossRef
13.
Alobid I, Benitez P, Bernal-Sprekelsen M, Roca J, Alonso J, Picado C, Mullol J (2005) Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments. Allergy 604:452–458CrossRef
14.
Amar YG, Frenkiel S, Sobol SE (2000) Outcome analysis of endoscopic sinus surgery for chronic sinusitis in patients having Samter’s triad. J Otolaryngol 291:7–12
15.
Haruna S, Nakanishi M, Otori N, Moriyama H (2004) Histopathological features of nasal polyps with asthma association: an immunohistochemical study. Am J Rhinol 183:165–172
16.
Suh YJ, Yoon SH, Sampson AP, Kim HJ, Kim SH, Nahm DH, Suh CH, Park HS (2004) Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma. Clin Exp Allergy 348:1270–1275CrossRef
17.
Advenier D, Guichard C, Kemeny JL, Tridon A, Gilain L (2002) Analysis of eosinophilia and ECP levels in blood and nasal secretions of 119 nasal polyposis patients. Ann Otolaryngol Chir Cervicofac 1196:322–329
18.
Scavuzzo MC, Fattori B, Ruffoli R, Rocchi V, Carpi A, Berni R, Giambelluca MA, Giannessi F (2005) Inflammatory mediators and eosinophilia in atopic and non-atopic patients with nasal polyposis. Biomed Pharmacother 596:323–329CrossRef
19.
in’t Veen JC, Smits HH, Hiemstra PS, Zwinderman AE, Sterk PJ, Bel EH (1999) Lung function and sputum characteristics of patients with severe asthma during an induced exacerbation by double-blind steroid withdrawal. Am J Respir Crit Care Med 1601:93–99
20.
Wynn R, Har-El G (2004) Recurrence rates after endoscopic sinus surgery for massive sinus polyposis. Laryngoscope 1145:811–813CrossRef
21.
Nishioka K, Saito C, Nagano T, Okano M, Masuda Y, Kuriyama T (1993) Eosinophil cationic protein in the nasal secretions of patients with mite allergic rhinitis. Laryngoscope 1032:189–192CrossRef
22.
Weber A, Kiefer J, Peters S, Schneider M, Bargon J, May A (1999) Eosinophilic cationic protein as a marker of nasal inflammation in patients with cystic fibrosis. Laryngoscope 109:1696–1702PubMedCrossRef
23.
Lavigne F, Nguyen CT, Cameron L, Hamid Q, Renzi PM (2000) Prognosis and prediction of response to surgery in allergic patients with chronic sinusitis. J Allergy Clin Immunol 1054:746–751CrossRef
24.
Voegels RL, de Melo Padua FG (2005) Expression of interleukins in patients with nasal polyposis. Otolaryngol Head Neck Surg 1324:613–619CrossRef
Metadata
Title
Clinical significance of eosinophilic cationic protein levels in nasal secretions of patients with nasal polyposis
Authors
Dong-Il Sun
Young-Hoon Joo
Hyeon-Jin Auo
Jun-Myung Kang
Publication date
01-07-2009
Publisher
Springer-Verlag
Published in
European Archives of Oto-Rhino-Laryngology / Issue 7/2009
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-008-0872-9

Other articles of this Issue 7/2009

European Archives of Oto-Rhino-Laryngology 7/2009 Go to the issue

Otology

Rheopheresis for idiopathic sudden hearing loss: results from a large prospective, multicenter, randomized, controlled clinical trial

Abstracts

Abstracts from the 1st Meeting of EAORL-HNS 27th-30th of June, 2009, Mannheim, Germany

Head and Neck

Post-tonsillectomy hemorrhage: assessment of risk factors with special attention to introduction of coblation technique

Otology

Body image and body concept in patients with chronic tinnitus

Laryngology

Endoscopic supraglottic laryngectomy: a proposal for a classification by the working committee on nomenclature, European Laryngological Society

Head and Neck

Sub-specialty training in head and neck surgical oncology in the European Union