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European Archives of Oto-Rhino-Laryngology

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01-01-2009 | Review Article

Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review

Authors: José Luis Llorente, Jhudit Pérez-Escuredo, César Alvarez-Marcos, Carlos Suárez, Mario Hermsen

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2009

Abstract

Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare epithelial cancer of the nasal cavities and paranasal sinuses. Exposure to wood dust particles is a strong etiological factor making it a professional disease. These tumors are locally aggressive with frequent local recurrences in up to 50% of cases. Metastasis to regional lymph nodes and distant metastasis are less frequent (10%). Invasion of the duramater and local recurrence are frequent and the major cause of death. Standard therapeutic modalities include surgery followed by radiotherapy in advanced stages, sometimes with chemotherapy treatment. The molecular genetic mechanisms underlying the development and progression of this tumor is not understood. Histopathologically, ITAC resembles colorectal adenocarcinoma and have directed early genetic studies to search for similar genetic alterations. Recently, genome-wide studies have identified a recurrent pattern of chromosomal aberrations. This review aims to describe the clinico-pathological characteristics of this relatively unknown tumor and to summarize the knowledge on genetic and chromosomal analyses up to the present time.

I. Álvarez C, Suárez JP, Rodrigo F, et al (1995) Prognostic factors in paranasal sinus cancer. Am J Otolaryngol 16:109–114

Barnes L (1986) Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Am J Pathol 10:192–202CrossRef

Núñez F, Suárez C, Alvarez I et al (1993) Sino-nasal adenocarcinoma: epidemiological and clinico-pathological study of 34 cases. J Otolaryngol 22:86–90PubMed

Klintenberg C, Olofsson J, Hellquist H et al (1984) Adenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure. Cancer 54:482–488PubMedCrossRef

Wilhelmsson B, Lundh B (1984) Nasal epithelium in woodworkers in the furniture industry. An histological and cytological study. Acta Otolaryngol 98:321–324PubMedCrossRef

Suárez C, Llorente JL, Fernandez León R et al (2004) Anterior craniofacial resection: oncologic outcome and complications in a series of 111 cases. Acta Otorrinolaringol Esp 55:27–33PubMed

Choussy O, Ferron C, Védrine PO et al (2008) GETTEC Study Group.Adenocarcinoma of ethmoid: a GETTEC retrospective multicenter study of 418 cases. Laryngoscope 118:437–443PubMed

Kleinsasser O, Schroeder HG (1988) Adenocarcinomas of the inner nose after exposure to wood dust. Morphological findings and relationships between histopathology and clinical behavior in 79 cases. Arch Otorhinolaringol 245:1–15CrossRef

Acheson ED, Codwell RH, Hadfield E et al (1968) Nasal cancer in the woodworkers in the furniture industry. Br Med J 2:587–596PubMedCrossRef

10.

Suárez C, Álvarez Álvarez I, Llorente Pendás JL (1999) Tumoures Rinosinusales. In: Tratado de Otorrinolaringología y Cirugía de cabeza y cuello. Tomo IV. Suárez C ed. Proyectos Médicos. Madrid, pp 2595–2628

11.

Llorente JL, Núñez F, Rodrigo JP, et al (2008) Sinonasal adenocarcinoma. Our experience. Acta Otolaryngol Esp 59:235–238

12.

Franchi A, Santucci M, Wenig B (2005) Adenocarcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, (eds.) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC, Lyon, pp 20–23

13.

Sobin LH, Wittekind C (2002) UICC. TNM classification of malignant tumours (sixth edition). Wiley-Liss, New York

14.

Valente G, Ferrari L, Kerim S et al (2004) Evidence of p53 immunohistochemical overexpression in ethmoidal mucosa of woodworkers. Cancer Detect Prev 28:99–106PubMedCrossRef

15.

Wolf J, Schmezer D, Fengel D et al (1998) The role of combination effects on the etiology of malignant nasal tumours in the wood-working industry. Acta Otolaryngol 535:3–16

16.

Bussi M, Gervasio CF, Riotino E et al (2002) Study of ethmoidal mucosa in a population al occupational high risk of sinonasal adenocarcinoma. Acta Otolaringol 122:197–201CrossRef

17.

Holt GR (1995) Sinonasal neoplams and inhaled air toxics. Otolaryngol 16:109–114CrossRef

18.

Van den Oever R (1996) Occupational exposure to dust and sinonasal cancer. An analysis of 386 cases reported to the NCCSF Cancer Registry. Acta Otorhinolaryngol Belg 50:19–24PubMed

19.

Boysen M, Voss R, Solberg LA (1986) The nasal mucosa in softwood exposed furniture workers. Acta Otolaryngol (Stockh) 101:501–502CrossRef

20.

Chen R, Rabinovitch PS, Crispin DA et al (2005) The initiation of colon cancer in a chronic inflammatory setting. Carcinogenesis 26:1513–1519PubMedCrossRef

21.

Clevers H (2004) At the crossroads of inflammation and cancer. Cell 118:671–674PubMedCrossRef

22.

Van der Woude CJ, Kleibeuker JH, Jansen PL et al (2004) Chronic inflammation, apoptosis and (pre)malignant lesions in the gastro-intestinal tract. Apoptosis 9:123–130PubMedCrossRef

23.

Holmila R, Cyr D, Luce D et al (2008) COX–2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. Int J Cancer 122:2154–2159PubMedCrossRef

24.

McKinney CD, Mills SE, Franquemont DW (1995) Sinonasal intestinal-type adenocarcinoma: immunohistochemical profile and comparison with colonic adenocarcinoma. Mod Pathol 8:421–426PubMed

25.

Mills SE, Fechner RE, Cantrell RW (1982) Aggressive sinonasal lesion resembling normal intestinal mucosa. Am J Surg Pathol 6:803–809PubMedCrossRef

26.

Pérez P, Domínguez O, González S et al (1999) Ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications. Cancer 86:255–264PubMedCrossRef

27.

Saber AT, Nielsen LR, Dictor M et al (1998) K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood dust or leather dust. Cancer Lett 126:59–65PubMedCrossRef

28.

Wu TT, Barnes L, Bakker A et al (1996) K-ras-2 and P53 genotiping of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Mod Pathol 9:199–204PubMed

29.

Yom SS, Rashid A, Rosenthal DI et al (2005) Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. Mod Pathol 18:315–319PubMedCrossRef

30.

Frattini M, Perrone F, Suardi S et al (2006) Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Head Neck 28:909–915PubMedCrossRef

31.

Licitra L, Suardi S, Bossi P et al (2004) Prediction of TP53 status for primary cisplatin, fluorouracil, and leucovorin chemotherapy in ethmoid sinus intestinal-type adenocarcinoma. J Clin Oncol 22:4901–4906PubMedCrossRef

32.

Perrone F, Oggionni M, Birindelli S et al (2003) TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Int J Cancer 105:196–203PubMedCrossRef

33.

Perez-Ordonez B, Huynh NN, Berean KW et al (2005) Expression of mismatch repair proteins, b-catenin, and E-cadherin in intestinal-type sinonasal adenocarcinoma. J Clin Pathol 57:1080–1083CrossRef

34.

Nazar G, Gonzalez MV, Garcia JM et al (2006) Amplification Of CCND1, EMS1, PIK3CA, and ErbB oncogenes in ethmoid sinus adenocarcinomas. Otolaryngol Head Neck Surg 135:135–139PubMedCrossRef

35.

Gallo O, Franchi A, Fini-Storchi I et al (1998) Prognostic significance of c-erbB2 oncoprotein expression in intestinal-type adenocarcinoma of the sinonasal tract. Head Neck 20:224–231PubMedCrossRef

36.

Götte K, Riedel F, Schäfer C et al (2000) Cilindrical cell carcinomas of the paranasal sinuses do not show p53 alterations but loss of heterozygosity at 3p and 17p. Int J Cancer 85:740–742PubMedCrossRef

37.

Ariza M, Llorente JL, Alvarez-Marcos C et al (2004) Comparative genomic hybridization in primary sinonasal adenocarcinomas. Cancer 100:335–341PubMedCrossRef

38.

Korinth D, Pacyna-Gengelbach M, Deutschmann N et al (2005) Chromosomal imbalances in wood dust-related adenocarcinomas of the inner nose and their associations with pathological parameters. J Pathol 207:207–215PubMedCrossRef

39.

Douglas EJ, Fiegler H, Rowan A et al (2004) Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res 64:4817–4825PubMedCrossRef

40.

Hermsen MAJA, Postma C, Baak JPA et al (2002) Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology 123:1109–1119PubMedCrossRef

41.

Nakao K, Mehta KR, Fridlyand J et al (2004) High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization. Carcinogenesis 25:1345–1357PubMedCrossRef

42.

Alessi DM, Trapp TK, Fu YS et al (1998) Nonsalivary sinonasal adenocarcinoma. Arch Otolaryngol Head Neck Surg 114:996–999

43.

Suárez C, Llorente JL, Fernandez León R et al (2004) Prognostic factors in sinonasal tumours involving the anterior skull base. Head Neck 26:136–144PubMedCrossRef

44.

Roux FX, Brasnu D, Devaux B et al (1994) Ethmoide sinus carcinomas: results and prognosis after neoadjuvant chemoterapy and combined surgery. A 10-year experience. Surg Neurol 42:98–104PubMedCrossRef

45.

Leclerc A, Martinez-Cortes M, Gerin M et al (1994) Sinonasal cancer and wood dust exposure: results from a case-control study. Am J Epidemiol 140:340–349PubMed

46.

Brasnu D, Laccourreye O, Bassot V et al (1996) Cisplatin-based neoadjuvant chemotherapy and combined resection for ethmoid sinus adenocarcinoma reaching and/or invading the skull base. Arch Otolaryngol Head Neck Surg 122:765–768PubMed

47.

Knegt PP, Ah-See KW, Van de Velden LA et al (2001) Adenocarcinoma of the ethmoidal sinus complex: surgical debulking and topical fluorouracil may be the optimal treatment. Arch Otolaryngol Head Neck Surg 127:141–146PubMed

Title: Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review
Authors: José Luis Llorente
Jhudit Pérez-Escuredo
César Alvarez-Marcos
Carlos Suárez
Mario Hermsen
Publication date: 01-01-2009
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 1/2009
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-008-0749-y

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Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review

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