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Archives of Gynecology and Obstetrics

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01-11-2019 | Cytostatic Therapy | Review

Primary yolk sac tumor of the endometrium: a case report and review of the literatures

Authors: Tao Lu, Liping Qi, Yanhui Ma, Guojiao Lu, Xiaolei Zhang, Peishu Liu

Published in: Archives of Gynecology and Obstetrics | Issue 5/2019

Abstract

Purpose

Yolk sac tumor (YST) is a malignant tumor derived from germ cells and usually occurs in the gonads. Extra-gonadal YST is most commonly seen in the vagina of children, but rarely in the cervix, vulva and endometrium. Primary YST of endometrium was extremely rare, standard treatment was still controversial and no guideline was established so far. The aim of the present study was to provide a comprehensive understanding and systematic thought for the management of primary YST of endometrium.

Methods

A systematic research of the literature was conducted in Scopus, PubMed database and Cochrane Library, including case reports and case series. We summarized clinical characteristics, treatments and prognosis of all collected cases. We collected data regarding patients, serum AFP level, initial symptoms, surgical information, postoperative chemotherapy and radiotherapy. A new case was also discussed.

Results

We found only 26 cases have been reported previously. We reported a new case of primary endometrial YST in a 27-year-old woman, and in this case, we creatively performed bilaterally ovarian preservation and used DC (docetaxel and carboplatin) regimen of postoperative chemotherapy, we achieved a relatively good prognosis during the follow-up period of 14 months.

Conclusion

Primary YST of endometrium, kind of highly malignant germ cell tumors, was extremely rare, of which initial symptom is usually abnormal vaginal bleeding. Standard treatment was still controversial and no guideline was established so far. Surgery combining with postoperative chemotherapy was considered effective for treatment of primary endometrial YST. Decision on whether to preserve ovaries in young patient with early stage needs careful consideration, comprehensive preoperative assessment and full communication. Intraoperative biopsy and strict postoperative follow-up are recommended. However, standard chemotherapy regimen and feasibility of postoperative radiotherapy remains to be discussed.

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Title: Primary yolk sac tumor of the endometrium: a case report and review of the literatures
Authors: Tao Lu
Liping Qi
Yanhui Ma
Guojiao Lu
Xiaolei Zhang
Peishu Liu
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keyword: Cytostatic Therapy
Published in: Archives of Gynecology and Obstetrics / Issue 5/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05309-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Primary yolk sac tumor of the endometrium: a case report and review of the literatures

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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