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01-11-2019 | Breast Cancer | Review

The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature

Authors: Ioannis Boutas, Anastasios Potiris, Walburgis Brenner, Antje Lebrecht, Annette Hasenburg, Sophia Kalantaridou, Marcus Schmidt

Published in: Archives of Gynecology and Obstetrics | Issue 5/2019

Abstract

Purpose

Galectin-3 is a M_r 31,000 protein that belongs to a family of carbohydrate-binding proteins. Galectin-3 has already been associated with protection against apoptosis through cell to cell or cell to matrix adhesion processes. It seems that galectin-3 plays an important role in tumor progression, cell growth, invasion and metastasis. Galectin-3 is the only member of the chimeric galectins that has an N-terminal glycine and proline domain and a C-terminal carbohydrate recognition domain that allows galectin-3 to accommodate larger structures such us polylactosaminoglycans and intervene to DNA damage repair process. In this systematic review, our primary goal is to identify the effect of galectin-3 expression in association with drug resistance and apoptosis inhibition in breast cancer.

Materials and methods

Scopus and PubMed databases were searched on 26 November 2018 using the following combination of keywords: (galectin-3 OR gal-3 OR LGALS3) AND (breast cancer) AND (chemoresistance OR (drug resistance) OR chemosensitivity). All the articles in English, regardless the time of publication, text availability and species included were initially accepted.

Results

In the majority of the included studies, the expression of galectin-3 had a protective role in cell survival via different pathways such as the response to DNA damage and repair or the inhibition of apoptosis after treatment with a chemotherapeutic agent.

Conclusion

Galectin-3 expression in breast tumors might be an important factor in the selection of the most suitable treatment.

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Title: The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature
Authors: Ioannis Boutas
Anastasios Potiris
Walburgis Brenner
Antje Lebrecht
Annette Hasenburg
Sophia Kalantaridou
Marcus Schmidt
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keywords: Breast Cancer
Breast Cancer
Published in: Archives of Gynecology and Obstetrics / Issue 5/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05292-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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