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Archives of Gynecology and Obstetrics

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01-04-2019 | Ovarian Hyperstimulation Syndrome | Gynecologic Endocrinology and Reproductive Medicine

Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS

Authors: Min Zheng, Gaoge Zuo, Jing Tong, Zi-Jiang Chen, Wei-Ping Li, Cong Zhang

Published in: Archives of Gynecology and Obstetrics | Issue 4/2019

Abstract

Purpose

Melatonin is an important factor in regulating numerous processes in human female reproduction. The aim of the present study was to compare melatonin levels in the follicular fluid (FF) of ovarian hyperstimulation syndrome (OHSS) women with those of non-OHSS women undergoing in vitro fertilization (IVF)-embryo transfer and to evaluate the relationship between FF melatonin levels and IVF outcomes in these women.

Methods

We determined FF melatonin levels in 20 OHSS women and 23 non-OHSS women on oocyte retrieval day.

Results

OHSS patients had significantly higher melatonin levels as compared to the non-OHSS women (P < 0.001). In addition, melatonin levels of the patients were significantly positively correlated with antral follicle count (AFC), serum anti-Müllerian hormone (AMH) levels, serum estradiol (E₂) levels on human chorionic gonadotropin (HCG) administration day, number of retrieved oocytes, total fertilized oocytes, normally fertilized oocytes, cleaved zygotes, top quality embryos on day 3, blastocysts obtained and embryos suitable for transplantation (day 3 embryos + day 5/6 blastocysts) (P < 0.05). While, the intrafollicular melatonin levels were significantly negatively correlated with age, basal serum follicle-stimulating hormone (FSH) levels, serum FSH levels on HCG administration day (P < 0.01). Since younger women with more AFC, higher AMH levels, higher serum E₂ levels and larger number of retrieved oocytes are much easier to encounter OHSS, while FF melatonin levels are significantly correlated with these five indices in our study, we propose that intrafollicular melatonin concentration can also be an important predictor of OHSS.

Conclusions

This is the first demonstration that FF melatonin levels were significantly higher in OHSS patients than in non-OHSS group and FF melatonin levels may serve as an important predictor of OHSS.

Li HW, Lee VC, Lau EY et al (2014) Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilization treatment. J Assist Reprod Genet 31(2):205–211CrossRef

Nastri CO, Ferriani RA, Rocha IA et al (2010) Ovarian hyperstimulation syndrome: pathophysiology and prevention. J Assist Reprod Genet 27(2):121–128CrossRef

Mocanu E, Redmond ML, Hennelly B et al (2007) Odds of ovarian hyperstimulation syndrome (OHSS)-time for reassessment. Hum Fertil (Camb) 10(3):175–181CrossRef

The Practice Committee of the American Society for Reproductive Medicine (HSRM) (2008) Ovarian hyperstimulation syndrome. Fertil Steril 90(Suppl. 5):S188–S193

Practice Committee, of American, Society for, Reproductive M (2008) Ovarian hyperstimulation syndrome. Fertil Steril 90(8):S188–S193

Geva E, Jaffe RB (2000) Role of vascular endothelial growth factor in ovarian physiology and pathology. Fertil Steril 74(3):429–438CrossRef

Levin ER, Rosen GF, Cassidenti DL et al (1998) Role of vascular endothelial cell growth factor in ovarian hyperstimulation syndrome. J Clin Investig 102(11):1978–1985CrossRef

Cui LL, Yang G, Pan J et al (2011) Tumor necrosis factor α knockout increases fertility of mice. Theriogenology 75(5):867–876CrossRef

Guo T, Zhang L, Cheng D et al (2015) Low-density lipoprotein receptor affects the fertility of female mice. Reprod Fertil Dev 27(8):1222–1232CrossRef

10.

Guo SJ, Yan XY, Shi FF et al (2018) Expression and distribution of the zinc finger protein, SNAI3, in mouse ovaries and pre-implantation embryos. J Reprod Dev 64(2):179–186CrossRef

11.

Liu M, Xie S, Zhou J (2018) Use of animal models for the imaging and quantification of angiogenesis. Exp Anim 67(1):1–6CrossRef

12.

Papanikolaou EG, Pozzobon C, Kolibianakis EM et al (2006) Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril 85(1):112–120CrossRef

13.

Reiter RJ, Tan DX, Manchester LC et al (2009) Melatonin and reproduction revisited. Biol Reprod 81(3):445–456CrossRef

14.

Tamura H, Takasaki A, Taketani T et al (2012) The role of melatonin as an antioxidant in the follicle. J Ovarian Res 5(5):5CrossRef

15.

Malpaux B, Migaud M, Tricoire H et al (2001) Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin. J Biol Rhythms 16(4):336–347CrossRef

16.

Kauffman AS, Clifton DK, Steiner RA (2007) Emerging ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci 30(10):504–511CrossRef

17.

Brzezinski A, Seibel MM, Lynch HJ et al (1987) Melatonin in human preovulatory follicular fluid. J Clin Endocrinol Metab 64(4):865–867CrossRef

18.

Rönnberg L, Kauppila A, Leppäluoto J et al (1990) Circadian and seasonal variation in human preovulatory follicular fluid melatonin concentration. J Clin Endocrinol Metab 71(2):492–496CrossRef

19.

Nakamura Y, Tamura H, Takayama H et al (2003) Increased endogenous level of melatonin inpreovulatory human follicles does not directly influence progesterone production. Fertil Steril 80(4):1012–1016CrossRef

20.

Reiter RJ, Tan DX, Fuentes-Broto L (2010) Melatonin: a multitasking molecule. Prog Brain Res 181(10):127–151CrossRef

21.

Tamura H, Nakamura Y, Korkmaz A (2009) Melatonin and the ovary: physiological and pathological implications. Fertil Steril 92(1):328–343CrossRef

22.

Whelan JG III, Vlahos NF (2000) The ovarian hyperstimulation syndrome. Fertil Steril 73(5):883–896CrossRef

23.

Golan A, Ron-el R, Herman A (1989) Ovarian hyperstimulation syndrome: an update review. Obstet Gynecol Surv 44(6):430–440CrossRef

24.

Brinsden PR (1999) A testbook of in vitro fertilization and assisted reproduction. The Parthenon Publishing Group Inc, New York

25.

Gardner PK, Lane M, Stevens J et al (2000) Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 73(6):1155–1158CrossRef

26.

Humaidan P, Quartarolo J, Papanikolaou EG (2010) Preventing ovarian hyperstimulation syndrome: guidance for the clinician. Fertil Steril 94(2):389–400CrossRef

27.

Tamura H, Taksaki A, Taketani T et al (2013) Melatonin as a free radical scavenger in the ovarian follicle. Endocr J 60(1):1–13CrossRef

28.

Nakamura Y, Smith M, Krishna A (1987) Increased number of mast cells in the dominant follicle of the cow: relationships among luteal, strenal and hilar regions. Biol Reprod 37(3):546–549CrossRef

29.

Brannstrom M, Mayrhofer G, Robertson SA (1993) Localization of leucocyte subsets in the rat ovary during the periovulatory period. Biol Reprod 48(2):277–286CrossRef

30.

Xie W, Zhou J (2018) Aberrant regulation of autophagy in mammalian diseases. Biol Lett 14(1):1–7CrossRef

31.

Gupta RK, Mille KP, Babus JK et al (2006) Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway. Toxicol Sci 93(2):382–389CrossRef

32.

Korzekwa AJ, Okuda K, Woclawek-Potocka I et al (2006) Nitric oxide induces apoptosis in bovine luteal cells. J Reprod Dev 52(3):353–361CrossRef

33.

Lanoix D, Lacasse AA, Reiter RJ et al (2012) Melatonin: the smart killer: the human trophoblast as a model. Mol Cell Endocrinol 348(1):22–28CrossRef

34.

Zavodnik IB, Domanski AV, Lapshina EA (2006) Melatonin directly scavenges free radicals generated in red blood cells and a cell-free system: chemiluminescence measurements and theoretical calculations. Life Sci 79(4):391–400CrossRef

35.

Weenen C, Laven JS, Von Bergh AR et al (2004) Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 10(2):77–83CrossRef

36.

Waldhauser F, Weiszenbacher G, Tatzer E et al (1988) Alterations in nocturnal serum melatonin levels in humans with growth and aging. J Clin Endocrinol Metab 66(3):648–652CrossRef

37.

Vakkuri O, Kivelä A, Leppäluoto J et al (1996) Decrease in melatonin precedes follicle-stimulating hormone increase during perimenopause. Eur J Endocrinol 135(2):188–192CrossRef

38.

Pappolla MA, Chyan YJ, Poeggeler B et al (2000) An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer’s disease. J Neural Transm 107(2):203–231CrossRef

39.

Bonilla E, Valero N, Chacin-Bonilla L (2004) Melatonin and viral infections. J Pineal Res 36(2):73–79CrossRef

40.

Hussain SA, Khadim HM, Khalaf BH et al (2006) Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Med J 27(10):1483–1488PubMed

41.

Lissoni P (2007) Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms. Pathol Biol 55(3–4):201–204CrossRef

42.

Tamura H, Takasaki A, Miwa I et al (2008) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 44(3):280–287CrossRef

Title: Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS
Authors: Min Zheng
Gaoge Zuo
Jing Tong
Zi-Jiang Chen
Wei-Ping Li
Cong Zhang
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Keyword: Ovarian Hyperstimulation Syndrome
Published in: Archives of Gynecology and Obstetrics / Issue 4/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4994-z

ACC 2024 Congress

Springer Medicine

Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS

Abstract

Purpose

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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