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Archives of Gynecology and Obstetrics

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01-09-2018 | Review

Meta-analysis of laparoscopy sentinel lymph node mapping in endometrial cancer

Authors: Lijun Wang, Fang Liu

Published in: Archives of Gynecology and Obstetrics | Issue 3/2018

Abstract

Objective

Sentinel lymph node (SLN) mapping for endometrial cancer (EC) is a contemporary technique that could provide benefits over traditional lymphadenectomy. Comprehensive published literature on sentinel lymph node mapping for laparoscopy surgery in EC, data extraction, evidence-based medicine-based methods, and meta-analysis are carried out to further explore sentinel lymph node mapping in laparoscopy surgery in EC. The application value provides basis for prevention and treatment of EC.

Materials and methods

We searched Medline, Embase, and the Cochrane Central for studies published before February 1, 2018 which had a sample size of at least ten patients, and reported the detection rate and/or sensitivity of the laparoscopy SLN biopsy. Statistical analysis was conducted using R-2.15.2 software.

Results

The overall detection rate of sentinel lymph node mapping was included in 389 patients of 8 studies, ranging from 25 to 71 patients, which was 96% (95% confidence interval 95–98). 366 patients were included in bilateral sentinel node detection rate, ranging from 30 to 71 patients; it was 73% (95% confidence interval, 69–77). The sensitivity of the overall detection rate of sentinel lymph node mapping was 96.3% with a sensitivity of 73.1% bilateral sentinel node detection rate.

Conclusions

Laparoscopy sentinel lymph node localization is feasible and accurately predicts lymph node status in patients with EC. For patients with early stage clinical disease, it is very important to screen patients with no lymph node metastasis, reduce the range of surgical resection, reduce the incidence of the corresponding complications, and improve the quality of patients.

Morice P, Leary A, Creutzberg C et al (2016) Endometrial cancer[J]. Lancet 387(10023):1094–1108CrossRefPubMed

Sharma C, Deutsch I, Lewin SN et al (2011) Lymphadenectomy influences the utilization of adjuvant radiation treatment for endometrial cancer[J]. Am J Obstet Gynecol 205(6):1–9CrossRef

Khoury-Collado F, Murray MP, Hensley ML et al (2011) Sentinel lymph node mapping for endometrial cancer improves the detection of metastatic disease to regional lymph nodes[J]. Gynecol Oncol 122(2):251–254CrossRefPubMed

Yost KJ, Cheville AL, Alhilli MM et al (2014) Lymphedema after surgery for endometrial cancer: prevalence, risk factors, and quality of life[J]. Obstet Gynecol 124(2 Pt 1):307CrossRefPubMedPubMedCentral

Levinson KL, Auer M, Escobar PF (2013) Evolving technologies in robotic surgery for minimally invasive treatment of gynecologic cancers[J]. Expert Rev Med Devices 10(5):603–610CrossRefPubMed

Mais V, Cirronis MG, Piras B et al (2011) Intraoperative lymphatic mapping techniques for endometrial cancer[J]. Expert Rev Anticancer Ther 11(1):83–93CrossRefPubMed

Lin H, Ding Z, Kota VG et al (2017) Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis[J]. Oncotarget 8(28):46601–46610PubMedPubMedCentral

Bodurtha Smith AJ, Fader AN, Tanner EJ (2017) Sentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis.[J]. Am J Obstet Gynecol 216(5):459–476CrossRefPubMed

Bats AS, Clément D, Larousserie F et al (2008) Does sentinel node biopsy improve the management of endometrial cancer? Data from 43 patients.[J]. J Surg Oncol 97(2):141–145CrossRefPubMed

10.

Barranger E, Delpech Y, Coutant C et al (2009) Laparoscopic sentinel node mapping using combined detection for endometrial cancer: a study of 33 cases–is it a promising technique?[J]. Am J Surg 197(1):1CrossRefPubMed

11.

Favero G, Pfiffer T, Ribeiro A et al (2015) Laparoscopic sentinel lymph node detection after hysteroscopic injection of technetium-99 in patients with endometrial cancer.[J]. Int J Gynecol Cancer 25(3):423–430CrossRefPubMed

12.

Taşkın S, Şükür YE, Altın D et al (2017) Laparoscopic near-infrared fluorescent imaging as an alternative option for sentinel lymph node mapping in endometrial cancer: a prospective study[J]. Int J Surg 47:13CrossRefPubMed

13.

Holub Z, Jabor A, Lukac J et al (2004) Laparoscopic detection of sentinel lymph nodes using blue dye in women with cervical and endometrial cancer[J]. Med Sci Monitor Int Med J Exp Clin Res 10(10):587–591

14.

Papadia A, Imboden S, Siegenthaler F et al (2016) Laparoscopic indocyanine green sentinel lymph node mapping in endometrial cancer[J]. Ann Surg Oncol 23(7):2206–2211CrossRefPubMedPubMedCentral

15.

Ballester M, Dubernard G, Rouzier R et al (2008) Use of the sentinel node procedure to stage endometrial cancer[J]. Ann Surg Oncol 15(5):1523–1529CrossRefPubMed

16.

Vidal F, Leguevaque P, Motton S et al (2013) Evaluation of the sentinel lymph node algorithm with blue dye labeling for early-stage endometrial cancer in a multicentric setting[J]. Int J Gynecol Cancer Off J Int Gynecol Cancer Soc 23(7):1237–1243CrossRef

17.

Kehoe SM, Miller DS (2011) The role of lymphadenectomy in endometrial cancer[J]. Clin Obstet Gynecol 54(2):235CrossRefPubMed

18.

Surynt E, Reinholz-Jaskolska M, Bidzinski M (2015) Laparoscopic sentinel lymph node mapping after cervical injection of indocyanine green for endometrial cancer—preliminary report[J]. Videosurg Other Miniinvasive Tech 10(3):406–412CrossRefPubMed

19.

Soliman PT, Westin SN, Dioun S et al (2017) A prospective validation study of sentinel lymph node mapping for high-risk endometrial cancer.[J]. Gynecol Oncol 146(2):234CrossRefPubMedPubMedCentral

20.

Smith AJB, Fader AN, Tanner EJ (2016) Sentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis[J]. Am J Obstet Gynecol 216(5):459–476CrossRef

21.

Jewell EL, Huang JJ, Abu-Rustum NR et al (2014) Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies[J]. Gynecol Oncol 133(2):274–277CrossRefPubMedPubMedCentral

22.

Paley PJ, Veljovich DS, Press J et al (2015) A prospective investigation of fluorescence imaging to detect sentinel lymph nodes at robotic-assisted endometrial cancer staging.[J]. American Journal of Obstetrics & Gynecology 215(1):117.e1–117.e7CrossRef

Title: Meta-analysis of laparoscopy sentinel lymph node mapping in endometrial cancer
Authors: Lijun Wang
Fang Liu
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 3/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4845-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Meta-analysis of laparoscopy sentinel lymph node mapping in endometrial cancer

Abstract

Objective

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

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