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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 4/2018

01-10-2018 | Maternal-Fetal Medicine

An effect of maternal nifedipine therapy on fetoplacental blood flow: a prospective study

Authors: Ahmet Namazov, Leonti Grin, Resul Karakus, Mehmet Uludogan, Habibe Ayvaci

Published in: Archives of Gynecology and Obstetrics | Issue 4/2018

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Abstract

Purpose

The aim of this study is to assess the effects of maternal nifedipine administration on placental and fetal blood flow.

Methods

A total of 29 patients with preterm labor diagnosis admitted to the tertiary care center, Zeynep Kamil Hospital, were evaluated. Before and 24–48 h after administration of oral nifedipine, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery, ductus venosus, umbilical artery, and maternal uterine artery blood flow.

Results

After 24 and 48 h of therapy, there were no changes in mean PI and RI in the umbilical arteries and ductus venosus (p > 0.05). Fetal middle cerebral artery and maternal uterine artery PI and RI values showed a significant reduction 24–48 h after oral nifedipine therapy (p < 0.05).

Conclusions

Our study showed that 24 and 48 h after oral nifedipine therapy, there is a significant increase in fetal MCA and maternal uterine artery blood flow, while fetal umbilical artery and ductus venosus Doppler values do not change.
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Metadata
Title
An effect of maternal nifedipine therapy on fetoplacental blood flow: a prospective study
Authors
Ahmet Namazov
Leonti Grin
Resul Karakus
Mehmet Uludogan
Habibe Ayvaci
Publication date
01-10-2018
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-018-4839-9

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