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Archives of Gynecology and Obstetrics

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Open Access 01-07-2018 | Maternal-Fetal Medicine

Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy

Authors: Bernd Froessler, Tijana Gajic, Gustaaf Dekker, Nicolette A. Hodyl

Published in: Archives of Gynecology and Obstetrics | Issue 1/2018

Abstract

Purpose

To evaluate the efficacy and safety of intravenous ferric carboxymaltose administration to pregnant women with varying severities of iron deficiency anemia and iron deficiency without anemia.

Methods

In this prospective observational study of local obstetric practice, we analyzed data from 863 pregnant women with iron deficiency according to anemia status and severity. All women were treated with intravenous ferric carboxymaltose in pregnancy. Treatment efficacy was assessed by repeat hemoglobin measurements at 3 and 6 week post-infusion and ferritin levels, where available. Safety was assessed by analysis of adverse events, fetal heart rate monitoring, and newborn health outcome data.

Results

Ferric carboxymaltose significantly increased hemoglobin in women with mild, moderate, and severe iron deficiency anemia and women with iron deficiency alone at 3 and 6 week post-infusion (p < 0.01 for all). No hemoconcentration occurred in iron-deficient women without anemia. No serious adverse events were recorded, with minor temporary side effects (including local skin irritation, nausea, and headache) occurring in 96 (11%) women. No adverse fetal or neonatal outcomes were observed.

Conclusions

Ferric carboxymaltose infusion corrects iron deficiency or various degrees of iron deficiency anemia efficaciously and safely pregnant women, and does not cause hemoconcentration.

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Title: Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy
Authors: Bernd Froessler
Tijana Gajic
Gustaaf Dekker
Nicolette A. Hodyl
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4782-9

At a glance: The STEP trials

Springer Medicine

Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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