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Archives of Gynecology and Obstetrics

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01-04-2018 | Maternal-Fetal Medicine

Independent association between uterine malformations and cervical insufficiency: a retrospective population-based cohort study

Authors: Salvatore Andrea Mastrolia, Yael Baumfeld, Reli Hershkovitz, David Yohay, Giuseppe Trojano, Adi Y. Weintraub

Published in: Archives of Gynecology and Obstetrics | Issue 4/2018

Abstract

Objective

The purpose of our study was to explore maternal and fetal outcomes in the second and third trimester in women with uterine malformations.

Study design

This was a retrospective population-based cohort study including women with a diagnosis of uterine malformation arised from workup for infertility or recurrent pregnancy loss, was accidental during pregnancy, or was noticed at the time of cesarean delivery.

Results

A total of 280,721 pregnancies met the inclusion criteria and were divided into two study groups: (1) pregnancies in women with uterine malformations (n = 1099); and (2) controls (n = 279,662). The rate of women presenting uterine malformations was 0.39%. The prevalence of cervical os insufficiency was significantly higher in women with a uterine malformation than in the control group (3.6 vs. 0.4%, p < 0.001). A multivariate analysis, performed to evaluate risk factors for cervical insufficiency in women with uterine malformations. Mullerian anomalies (OR 6.19, 95% CI 4.41–8.70, p < 0.001), maternal age (OR 1.05, 95% CI 1.04–1.06, p < 0.001), recurrent abortions (OR 12.93, 95% CI 11.43–14.62, p < 0.001), and ethnicity (OR 2.86, 95% CI 2.454–3.34, p < 0.001) were found to be independently associated with the development of cervical insufficiency.

Conclusion

Uterine anomalies have a strong association with cervical insufficiency. Women with uterine anomalies have an increased risk to develop pregnancy complications that arise from a loss in cervical function during the midtrimester or early third trimester.

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Title: Independent association between uterine malformations and cervical insufficiency: a retrospective population-based cohort study
Authors: Salvatore Andrea Mastrolia
Yael Baumfeld
Reli Hershkovitz
David Yohay
Giuseppe Trojano
Adi Y. Weintraub
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4663-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Independent association between uterine malformations and cervical insufficiency: a retrospective population-based cohort study

Abstract

Objective

Study design

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Study design

Results

Conclusion

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