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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 5/2017

01-11-2017 | Maternal-Fetal Medicine

RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy

Authors: Ashok Kumar, Sheetal Sharma, Premashish Kar, Sarita Agarwal, Siddhartha Ramji, Syed Akhtar Husain, Sudha Prasad, Shashi Sharma

Published in: Archives of Gynecology and Obstetrics | Issue 5/2017

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Abstract

Background and aim

The basis of host response in hepatitis E virus (HEV)—related liver disease during pregnancy—is still unclear. The study aims to evaluate anthropometric parameters and biochemical nutritional parameters in hepatitis E infection during pregnancy and correlate it with severity of the disease.

Methods

A total of consecutive 267 pregnant women with jaundice were recruited. The jaundiced patients were classified as acute viral hepatitis (AVH) or acute liver failure (ALF). The study group included 144 pregnant women with HEV infection and 144 healthy asymptomatic age and gestational age-matched pregnant women as controls. Nutritional factors were evaluated on basis of anthropometric parameters and biochemical factors. Serum prealbumin and folate were assayed by ELISA kit.

Results

All nutritional parameters were significantly lower in pregnant women with HEV infection as compared with healthy pregnant controls. Some of the nutritional parameters significantly lower in ALF pregnant patients compared to AVH pregnant patients in HEV group. Linear regression analysis of the AVH group showed that serum total protein and mid-upper arm circumference (MUAC) were significant predictors for bilirubin, body mass index (BMI) could significantly predict viral load level, and total protein, prealbumin, folate, and tricep skin fold thickness (TSFT) could significantly predict prothrombin time. In ALF group, serum prealbumin could significantly predict bilirubin levels and MUAC could significantly predict prothrombin time.

Conclusion

Malnutrition might confer a higher predisposition for HEV infection during pregnancy and is associated with increased severity of disease in terms of occurrence of ALF.
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Metadata
Title
RETRACTED ARTICLE: Impact of maternal nutrition in hepatitis E infection in pregnancy
Authors
Ashok Kumar
Sheetal Sharma
Premashish Kar
Sarita Agarwal
Siddhartha Ramji
Syed Akhtar Husain
Sudha Prasad
Shashi Sharma
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 5/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4501-y

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