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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 4/2017

01-10-2017 | Review

A meta-analysis of atosiban supplementation among patients undergoing assisted reproduction

Authors: Jie Li, Yang Chen, Anran Wang, Haiying Zhang

Published in: Archives of Gynecology and Obstetrics | Issue 4/2017

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Abstract

Objectives

Evidence for the efficacy of atosiban in improving pregnancy outcomes among patients undergoing assisted reproductive technology (ART) remains inconsistent.

Methods

The PubMed, EMBASE, and CNKI databases were searched using keywords such as ‘atosiban’, ‘infertility’, and ‘ART’. Studies that explored the efficacy of atosiban in the field of ART for patients with embryo transfer (ET) were included if they evaluated pregnancy outcomes. Combing using subgroups and sensitivity analysis were conducted, and risk ratios (RRs), and 95% confidence intervals (CIs) were calculated.

Results

Six studies were included. Atosiban treatment could improve pregnancy outcomes for all patients undergoing ET, especially for the subgroups of patients with repeated implantation failure (RIF) (implantation rate: RR = 1.806, 95% CI = 1.473–2.215; clinical pregnancy rate: RR = 1.725, 95% CI = 1.394–2.135; live birth rate: RR = 2.141, 95% CI = 1.494–3.068), as shown by the comparison with placebo or no-treatment groups. However, no statistical significance was detected in subgroups of patients undergoing their first or second ET cycle. In addition, no significant differences were observed in positive pregnancy tests, miscarriage rates, multiple pregnancy rates, or ectopic pregnancy rates.

Conclusions

Supplementation with atosiban has a positive effect on ART and embryo transfer procedure, especially for women undergoing their third or more ET cycle.
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Metadata
Title
A meta-analysis of atosiban supplementation among patients undergoing assisted reproduction
Authors
Jie Li
Yang Chen
Anran Wang
Haiying Zhang
Publication date
01-10-2017
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4455-0

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