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Archives of Gynecology and Obstetrics

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01-08-2017 | Gynecologic Oncology

Rhabdomyosarcoma of the lower female genital tract: an analysis of 144 cases

Authors: Dimitrios Nasioudis, Michail Alevizakos, Eloise Chapman-Davis, Steven S. Witkin, Kevin Holcomb

Published in: Archives of Gynecology and Obstetrics | Issue 2/2017

Abstract

Purpose

The aim of the present study was to elucidate the clinico-pathological characteristics of female patients with lower genital tract rhabdomyosarcoma (RMS) stratified by age group and investigate their prognosis, using a multi-institutional database.

Methods

The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database was accessed (1973–2013) and a cohort of females diagnosed with RMS of the lower genital tract (vulva, vagina, cervix) was drawn. Five-year overall survival (OS) rate was estimated following generation of Kaplan–Meier curves and compared with the log-rank test.

Results

A total of 144 eligible cases were identified; 51.4 and 48.6% originated from the vagina/vulva and the cervix, respectively. Median patient age was 16 years and distant metastases were rare (ten cases). The majority of tumors were of embryonal histology (75.7%). Non-embryonal RMS was more prevalent in the older patient groups. Tumors originating from the cervix were more common among adolescents and premenopausal women. Rate of LN involvement was 52.9 and 20% for vulvovaginal and cervical tumors (p = 0.02). Five-year OS rate was 68.4%; factors associated with better OS were younger age, absence of distant metastasis, embryonal histology, negative LNs, and performance of surgery. For prepubertal girls and adolescents, radical surgery did not confer a survival benefit compared to local tumor excision.

Conclusion

RMS of the lower genital tract primarily affects prepubertal girls and adolescents, who have excellent survival rates; however, outcomes for adults remain poor.

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Title: Rhabdomyosarcoma of the lower female genital tract: an analysis of 144 cases
Authors: Dimitrios Nasioudis
Michail Alevizakos
Eloise Chapman-Davis
Steven S. Witkin
Kevin Holcomb
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4438-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Rhabdomyosarcoma of the lower female genital tract: an analysis of 144 cases

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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