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Archives of Gynecology and Obstetrics

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01-08-2017 | Maternal-Fetal Medicine

Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation

Published in: Archives of Gynecology and Obstetrics | Issue 2/2017

Abstract

Purpose

To confirm reduced expression of soluble fms-like tyrosine kinase 1 (sFlt-1) in accreta/increta.

Methods

Formalin-fixed tissue sections from 11 peripartum hysterectomies with invasive placentation and 5 controls were stained for sFlt-1. Stain intensity was scored in selected 100× microscopic fields. We compared sFlt-1 expression in invasive areas among cases, non-invasive areas among cases and areas from control placentas.

Results

Chorionic villi displayed significantly decreased sFlt-1 expression in invasive areas of cases compared to control placentas (p = 0.003), as well as in non-invasive areas of cases compared to control placentas (p = 0.01). There was no difference in sFlt-1 expression between invasive and non-invasive areas among cases.

Conclusions

Expression of sFlt-1 is diminished in villous trophoblasts from patients with placenta increta or percreta. Local depth of invasion was not associated with sFlt-1 expression, suggesting a more global abnormality across the implantation site rather than localized to areas of histologic invasion.

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Title: Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation
Publication date: 01-08-2017
Published in: Archives of Gynecology and Obstetrics / Issue 2/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4432-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Down-regulation of soluble fms-like tyrosine kinase 1 expression in invasive placentation

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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