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Archives of Gynecology and Obstetrics

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01-08-2017 | Maternal-Fetal Medicine

Ponderal index at birth associates with later risk of gestational diabetes mellitus

Authors: Mie Crusell, Peter Damm, Torben Hansen, Oluf Pedersen, Charlotte Glümer, Allan Vaag, Jeannet Lauenborg

Published in: Archives of Gynecology and Obstetrics | Issue 2/2017

Abstract

Purpose

Low birth weight (BW) and low ponderal index (PI) are associated with increased risk of type 2 diabetes mellitus. This study has two purposes: first to investigate the influence of PI on the risk of gestational diabetes mellitus (GDM); second, to study the association between glucose metabolism and BW in women with previous GDM.

Methods

GDM cohort: 185 women with GDM in 1978–1996, attending a follow-up study in 2000–2002. Control cohort: 1137 women from a population-based diabetes screening study (Inter99) in a neighbouring county in 1999–2001. BW and birth length were collected from the original midwifery records. BW and PI were stratified into tertiles for analysis.

Results

PI in the lower tertiles was associated with an increased risk of GDM [odds ratio 1.59 (95% confidence interval 1.07–2.36, p = 0.021)]. Among women with previous GDM, the area under the curve (AUC) for plasma levels of glucose and insulin during an OGTT was highest for the lower tertiles of BW (for AUCglucose p = 0.048, for AUCinsulin p = 0.047 adjusted for age and BMI).

Conclusions

Lower PI is associated with increased risk of GDM. In women with previous GDM, lower BW is associated with a more severe impairment of glucose metabolism one to two decades after the pregnancy complicated by GDM.

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Title: Ponderal index at birth associates with later risk of gestational diabetes mellitus
Authors: Mie Crusell
Peter Damm
Torben Hansen
Oluf Pedersen
Charlotte Glümer
Allan Vaag
Jeannet Lauenborg
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4427-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Ponderal index at birth associates with later risk of gestational diabetes mellitus

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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