Factors affecting serum sclerostin in postmenopausal women

Excerpt

I read with interest the article titled “The relationship between postmenopausal women’s sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products” by Kalem et al. [1]. The authors investigated the relationship between serum sclerostin levels, bone mineral density, and other related factors in 135 postmenopausal women. There was a positive relationship between serum sclerostin levels and body mass index in all subjects and also in sub-population, stratified by the existence of osteoporosis. In addition, negative relationships between serum sclerostin levels and bone mineral density scores in several parts of the body were observed, which were independent from age. Furthermore, there was no significant difference in the mean value of serum sclerostin levels in relation to smoking, coffee consumption, milk and dairy products, bisphosphonate use, histories of hypertension, and diabetes. I have a query about their study with special reference to statistical method. …