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Archives of Gynecology and Obstetrics

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01-05-2017 | Maternal-Fetal Medicine

Maternal and neonatal outcomes after induction of labor: a population-based study

Authors: Christoph Zenzmaier, Hermann Leitner, Christoph Brezinka, Willi Oberaigner, Martina König-Bachmann

Published in: Archives of Gynecology and Obstetrics | Issue 5/2017

Abstract

Purpose

To evaluate maternal and neonatal outcomes at and beyond term associated with induction of labor compared to spontaneous onset of labor stratified by week of gestational age.

Methods

In this retrospective cohort study, data form 402,960 singleton pregnancies from the Austria Perinatal Registry were used to estimate odds ratios of secondary cesarean delivery, operative vaginal delivery, epidural analgesia, fetal scalp blood testing, episiotomy, 3rd/4th-degree lacerations, retained placenta, 5-min APGAR <7, umbilical artery pH <7.1, and admission to neonatal intensive care unit. Multivariate logistic regression models based on deliveries with gestational age ≥37 + 0 were applied for adjustment for possible confounders.

Results

Induction of labor was associated with increased odds for cesarean delivery (adjusted OR; 99% confidence interval: 1.53; 1.45–1.60), operative vaginal delivery (1.21; 1.15–1.27), epidural analgesia (2.12; 2.03–2.22), fetal scalp blood testing (1.40; 1.28–1.52), retained placenta (1.32; 1.22–1.41), 5-min APGAR <7 (1.55; 1.27–1.89), umbilical artery pH <7.1 (1.26; 1.15–1.38), and admission to neonatal intensive care unit (1.41; 1.31–1.51). In a subgroup of induction of labor with the indication, “post-term pregnancy” induction was similarly associated with adverse outcomes.

Conclusions

In Austria, induction of labor is associated with increased odds of adverse maternal and neonatal outcomes. However, due to residual confounding, currently, no recommendations for treatment can be derived.

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Title: Maternal and neonatal outcomes after induction of labor: a population-based study
Authors: Christoph Zenzmaier
Hermann Leitner
Christoph Brezinka
Willi Oberaigner
Martina König-Bachmann
Publication date: 01-05-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4354-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Maternal and neonatal outcomes after induction of labor: a population-based study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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