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01-04-2017 | Gynecologic Oncology

Follow up in women with biopsy diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL): how long should it be?

Authors: Andrea Ciavattini, Nicolò Clemente, Dimitrios Tsiroglou, Francesco Sopracordevole, Matteo Serri, Giovanni Delli Carpini, Maria Papiccio, Paolo Cattani

Published in: Archives of Gynecology and Obstetrics | Issue 4/2017

Abstract

Aim

To analyse the regression rate and the risk of persistence or progression of the lesions in women with a histopathological diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL).

Materials and methods

Retrospective cohort study of women with biopsy diagnosis of cervical LSIL, from January 2010 to December 2013. After the initial diagnosis of LSIL, all the women underwent scheduled follow-up examinations with cytology every 6 months for 2 years and an HPV test after 1 year.

Results

At the 24 -month follow-up, the regression of cervical LSIL was observed in 88.5% of the women. 10.8% of the women had a persistent lesion, while a progression towards cervical HSIL was reported in 0.7% of the women. The risk of persistence or progression of histological LSIL was higher in women with ASC-H or HSIL on the referral cytology and in tobacco users.

Conclusion

In women with biopsy diagnosis of cervical LSIL, preceded by ASCUS or LSIL on cytology, a high rate of regression was observed and, in most of the cases, the regression occurred in the first year of follow-up. In women with cervical LSIL, preceded by ASC-H or HSIL on cytology, and in tobacco users, a higher risk of persistence and progression was observed. Thus, in these cases, repeated follow-up examinations, even with the HR-HPV test, are advisable.

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Title: Follow up in women with biopsy diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL): how long should it be?
Authors: Andrea Ciavattini
Nicolò Clemente
Dimitrios Tsiroglou
Francesco Sopracordevole
Matteo Serri
Giovanni Delli Carpini
Maria Papiccio
Paolo Cattani
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4335-7

At a glance: The STEP trials

Springer Medicine

Follow up in women with biopsy diagnosis of cervical low-grade squamous intraepithelial lesion (LSIL): how long should it be?

Abstract

Aim

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Aim

Materials and methods

Results

Conclusion

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