Top

Archives of Gynecology and Obstetrics

Published in:

01-03-2017 | Gynecologic Oncology

Dietary vitamin B2 intake and breast cancer risk: a systematic review and meta-analysis

Authors: Lanting Yu, Yuyan Tan, Lin Zhu

Published in: Archives of Gynecology and Obstetrics | Issue 3/2017

Abstract

Background

Epidemiological studies assessing the relationship between dietary vitamin B2 and the risk of breast cancer have produced inconsistent results. Thus, we conducted this meta-analysis of epidemiologic studies to evaluate this association.

Methods

We searched English-language MEDLINE publications and conducted a manual search to screen eligible articles. A random-effect model was used to pool study-specific risk estimates. Egger’s linear regression test was also used to detect publication bias in meta-analysis.

Results

In our meta-analysis, ten studies comprising totally 12,268 breast cancer patients were available in the analyses. Pooled relative risk (RR) comparing the highest to the lowest vitamin B2 intake and breast cancer incidence was 0.85 [95% confidence interval (CI) = 0.76–0.95]. No significant heterogeneity existed across the studies (P = 0.086, I ² = 40.7%). No publication bias was found. The results of dose–response analysis also showed that an increment of 1 mg/day was inversely related to the risk of breast cancer (RR = 0.94; 95% CI = 0.90–0.99).

Conclusions

Results from our meta-analysis indicated that dietary vitamin B2 intake is weakly related to the reduced risk of breast cancer. Additional research is also necessary to further explore this association.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65(2):87–108CrossRefPubMed

Hulka BS, Moorman PG (2008) Breast cancer: hormones and other risk factors. Maturitas 61(1–2):203–213CrossRefPubMed

Narod SA (2011) Hormone replacement therapy and the risk of breast cancer. Nat Rev Clin Oncol 8(11):669–676CrossRefPubMed

Xue F, Michels KB (2007) Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence. Lancet Oncol 8(12):1088–1100CrossRefPubMed

Tirona MT, Sehgal R, Ballester O (2010) Prevention of breast cancer (part I): epidemiology, risk factors, and risk assessment tools. Cancer Investig 28(7):743–750CrossRef

Stevens VL, McCullough ML, Pavluck AL, Talbot JT, Feigelson HS et al (2007) Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence. Cancer Epidemiol Biomark Prev 16(6):1140–1147CrossRef

Kim YI (2004) Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomark Prev 13(4):511–519

Zhang YF, Shi WW, Gao HF, Zhou L, Hou AJ, Zhou YH (2014) Folate intake and the risk of breast cancer: a dose-response meta-analysis of prospective studies. PLoS One 9(6):e100044CrossRefPubMedPubMedCentral

Larsson SC, Giovannucci E, Wolk A (2007) Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 99(1):64–76CrossRefPubMed

10.

Liu Y, Yu QY, Zhu ZL, Tang PY, Li K (2015) Vitamin B2 intake and the risk of colorectal cancer: a meta-analysis of observational studies. Asian Pac J Cancer Prev 16(3):909–913CrossRefPubMed

11.

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 51(4):264–269 (W264) CrossRef

12.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al (2012) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 26 Mar 2016

13.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed

14.

Greenland S, Longnecker MP (1992) Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 135(11):1301–1309CrossRefPubMed

15.

Orsini N, Bellocco R, Greenland S (2006) Generalized least squares for trend estimation of summarized doseresponse data. Stata J 6:40–57

16.

Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558CrossRefPubMed

17.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634CrossRefPubMedPubMedCentral

18.

Cho E, Holmes M, Hankinson SE, Willett WC (2007) Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women. Cancer Epidemiol Biomark Prev 16(12):2787–2790CrossRef

19.

Xu X, Gammon MD, Wetmur JG, Bradshaw PT, Teitelbaum SL, Neugut AI et al (2008) B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer. Cancer Epidemiol Biomark Prev 17(8):2109–2116CrossRef

20.

Dorjgochoo T, Shrubsole MJ, Shu XO, Lu W, Ruan Z, Zheng Y et al (2008) Vitamin supplement use and risk for breast cancer: the Shanghai Breast Cancer Study. Breast Cancer Res Treat 111(2):269–278CrossRefPubMed

21.

Stevens VL, McCullough ML, Sun J, Gapstur SM (2010) Folate and other one-carbon metabolism—related nutrients and risk of postmenopausal breast cancer in the Cancer Prevention Study II Nutrition Cohort. Am J Clin Nutr 91(6):1708–1715CrossRefPubMed

22.

Maruti SS, Ulrich CM, Jupe ER, White E (2009) MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res 11(6):R91CrossRefPubMedPubMedCentral

23.

Negri E, La Vecchia C, Franceschi S, D’Avanzo B, Talamini R, Parpinel M et al (1996) Intake of selected micronutrients and the risk of breast cancer. Int J Cancer 65(2):140–144CrossRefPubMed

24.

Levi F, Pasche C, Lucchini F, La Vecchia C (2001) Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91(2):260–263CrossRefPubMed

25.

Chen J, Gammon MD, Chan W, Palomeque C, Wetmur JG, Kabat GC et al (2005) One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 65(4):1606–1614CrossRefPubMed

26.

Kabat GC, Miller AB, Jain M, Rohan TE (2008) Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer 99(5):816–821CrossRefPubMedPubMedCentral

27.

Ma E, Iwasaki M, Kobayashi M, Kasuga Y, Yokoyama S, Onuma H et al (2009) Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case–control study in japan. Nutr Cancer 61(4):447–456CrossRefPubMed

28.

Maruti SS, Ulrich CM, White E (2009) Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am J Clin Nutr 89(2):624–633CrossRefPubMed

29.

Shrubsole MJ, Shu XO, Li HL, Cai H, Yang G, Gao YT et al (2011) Dietary B vitamin and methionine intakes and breast cancer risk among Chinese women. Am J Epidemiol 173(10):1171–1182CrossRefPubMedPubMedCentral

30.

Bassett JK, Baglietto L, Hodge AM, Severi G, Hopper JL, English DR et al (2013) Dietary intake of B vitamins and methionine and breast cancer risk. Cancer Causes Control 24(8):1555–1563CrossRefPubMed

31.

Yang D, Baumgartner RN, Slattery ML, Wang C, Giuliano AR, Murtaugh MA et al (2013) Dietary intake of folate, B-vitamins and methionine and breast cancer risk among hispanic and non-hispanic white women. PLoS One 8(2):e54495CrossRefPubMedPubMedCentral

32.

Cancarini I, Krogh V, Agnoli C, Grioni S, Matullo G, Pala V et al (2015) Micronutrients involved in one-carbon metabolism and risk of breast cancer subtypes. PLoS One 10(9):e0138318CrossRefPubMedPubMedCentral

33.

Rivlin RS (1970) Riboflavin metabolism. N Engl J Med 283:463–472CrossRefPubMed

34.

Powers HJ (2003) Riboflavin (vitamin B-2) and health. Am J Clin Nutr 77(6):1352–1360PubMed

Title: Dietary vitamin B2 intake and breast cancer risk: a systematic review and meta-analysis
Authors: Lanting Yu
Yuyan Tan
Lin Zhu
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 3/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4278-4

At a glance: The STEP trials

Springer Medicine

Dietary vitamin B2 intake and breast cancer risk: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 3/2017

Prognostic value of MMP-2 for patients with ovarian epithelial carcinoma: a systematic review and meta-analysis

Meta-analysis demonstrates no association between p16 ink4a promoter methylation and epithelial ovarian cancer

Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis

The impact of ultra-radical surgery in the management of patients with stage IIIC and IV epithelial ovarian, fallopian tube, and peritoneal cancer

The effect of dexpanthenol on experimentally induced ovarian ischaemia/reperfusion injury: a biochemical and histopathological evaluation

Worldwide prevalence of adverse pregnancy outcomes associated with in vitro fertilization/intracytoplasmic sperm injection among multiple births: a systematic review and meta-analysis based on cohort studies