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Archives of Gynecology and Obstetrics

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Open Access 01-02-2017 | Maternal-Fetal Medicine

Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review

Authors: Maryam Moayeri, Karst Y. Heida, Arie Franx, Wilko Spiering, Monique W. M. de Laat, Martijn A. Oudijk

Published in: Archives of Gynecology and Obstetrics | Issue 2/2017

Abstract

Background

It is unknown whether an unfavorable (atherogenic) lipid profile and homocysteine level, which could supersede clinical cardiovascular disease, is also associated with an increased risk of spontaneous preterm delivery (sPTD). A systematic review of studies assessing the lipid profile and homocysteine value of women with sPTD compared to women with term delivery in pre-pregnancy and during pregnancy.

Methods

A systematic search of peer-reviewed articles published between January 1980 and May 2014 was performed using MEDLINE, EMBASE and the Cochrane database. We included case–control and cohort studies that examined triglycerides, high/low density lipoprotein cholesterol, total cholesterol and homocysteine in women with sPTD. Articles were subdivided in pre-pregnancy, first, second and third trimester. Of 708 articles reviewed for eligibility, 14 met our inclusion criteria.

Results and conclusion

Nine cohort studies and five case–control studies were analyzed, reporting on 1466 cases with sPTD and 11296 controls with term delivery. The studies suggest a possible elevated risk of sPTD in woman with high TG levels, no association of high and low density lipoprotein cholesterol with the risk of sPTD was found. High homocysteine levels are associated with sPTD in the second trimester. The role of triglycerides and homocysteine in sPTD should be explored further.

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Title: Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review
Authors: Maryam Moayeri
Karst Y. Heida
Arie Franx
Wilko Spiering
Monique W. M. de Laat
Martijn A. Oudijk
Publication date: 01-02-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4216-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review

Abstract

Background

Methods

Results and conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results and conclusion

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