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Archives of Gynecology and Obstetrics

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01-01-2017 | Gynecologic Endocrinology and Reproductive Medicine

Ovarian reserve in women with a previous history of severe pre-eclampsia

Authors: Priya Bhide, Åse Vårtun, Berit Aune, Kari Flo, Purusotam Basnet, Ganesh Acharya

Published in: Archives of Gynecology and Obstetrics | Issue 1/2017

Abstract

Purpose

Severe pre-eclampsia affects maternal health with long-term consequences. It is postulated that during the process of implantation and cell differentiation, embryos resulting from the fertilization of ageing oocytes produce malfunctioning trophoectoderm leading to placental dysfunction. Therefore, severe pre-eclampsia may be associated with a decreased ovarian reserve. The objective of this study was to compare serum markers of ovarian reserve and function between women who had severe pre-eclampsia and those who had normal pregnancies.

Methods

Twenty women who had severe pre-eclampsia (PE) and 20 who had uncomplicated pregnancies (controls) matched for age and body mass index were included in the study. Fasting blood samples were taken during the follicular phase (day 5) of the menstrual cycle 6 months to 5 years after the delivery. Serum was separated and frozen at −70 °C until analyzed for anti-Mϋllerian hormone (AMH), total and free testosterone (TT), free-androgen index (FAI), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) hormone to evaluate ovarian reserve and function, and the results were compared between two groups.

Results

The median AMH was 0.91 ng/mL in PE group compared to 0.72 ng/mL in controls (p = 0.995). No significant differences were found between the two groups in the levels of LH (5.65 vs. 5.4 IU/L, respectively, p = 0.897) and FSH (4.95 vs. 5.1 IU/L, respectively, p = 0.523). However, total and free-TT levels as well as FAI were significantly lower in the PE group compared to controls (p = 0.017, p = 0.006, and p = 0.011, respectively).

Conclusions

Ovarian reserve and function are not altered significantly in women with a previous history of pre-eclampsia compared with women who had an uncomplicated pregnancy.

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Title: Ovarian reserve in women with a previous history of severe pre-eclampsia
Authors: Priya Bhide
Åse Vårtun
Berit Aune
Kari Flo
Purusotam Basnet
Ganesh Acharya
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4193-8

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Ovarian reserve in women with a previous history of severe pre-eclampsia

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

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