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Archives of Gynecology and Obstetrics

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01-01-2017 | Gynecologic Oncology

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

Authors: Giuseppe Santoro, Antonio Simone Laganà, Antonio Micali, Valeria Barresi, Valentina Giacobbe, Vittorio Palmara

Published in: Archives of Gynecology and Obstetrics | Issue 1/2017

Abstract

Introduction

Placental site trophoblastic tumor (PSTT) is a form of gestational trophoblastic disease that originates from the implantation of an intermediate trophoblast. It was described for the first time by Von F. Marchand in 1895 as belonging to chorioepithelioma sui generis, a pathological condition with many variations and a progressive degree of malignancy.

Methods

We have conducted a literature review in MEDLINE about epidemiology, etiopathogenesis and clinical features of PSTT. Moreover, a case that occurred in our institution was reported.

Results

Our research has highlighted that existing published data about PSTT are not uniform. The number of cases described in the literature has updated and the clinical features of selected “case series” of patients diagnosed with PSTT were showed. The etiopathogenesis was discussed. It was noted that current prognostic factors still allow important information regarding PSTT to be obtained, albeit fragmentary.

Conclusions

The lack of uniformity in data collection seen so far has limited full knowledge of PSTT. For this reason, we suggest a model (PSTT model) that collects and unifies PSTT evidence as this would be useful to identify worldwide precise prognostic factors, which are still lacking. When PSTT is diagnosed, the proper procedure seems to be total hysterectomy, with sampling of pelvic lymph nodes and ovarian conservation. For advanced-stage diseases, (stage III and IV) a combination of surgery and polychemotherapy is suggested.

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Title: Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside
Authors: Giuseppe Santoro
Antonio Simone Laganà
Antonio Micali
Valeria Barresi
Valentina Giacobbe
Vittorio Palmara
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2017
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4182-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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