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Archives of Gynecology and Obstetrics

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01-08-2016 | Gynecologic Oncology

MarginProbe© reduces the rate of re-excision following breast conserving surgery for breast cancer

Authors: Jens-Uwe Blohmer, Julia Tanko, Janina Kueper, Jessica Groß, Ragna Völker, Anna Machleidt

Published in: Archives of Gynecology and Obstetrics | Issue 2/2016

Abstract

Purpose

A positive margin status after breast conserving surgery (BCS) is one of the strongest predictors for local recurrence of intraductal (DCIS) and invasive carcinoma. As much as 20–50 % of patients with BCS need to undergo a second operation to receive free margins. In this study we tested the clinical performance of MarginProbe© (Dune Medical Devices, Paoli, PA, USA), a device for the intraoperative evaluation of surgical margins.

Methods

A prospective clinical study was performed: The device was utilized in BCS of 150 patients treated at a single facility from November 2012 to June 2013. The re-excision rate was compared to the re-excision rate of a historical group of 172 patients treated with BCS at the same hospital without the application of the device. We analyzed whether the results of MarginProbe© are affected by the morphology, grading, size of the tumor, breast density, age, BMI or the use of marker-wires.

Results

The application of MarginProbe© resulted in an overall decreased re-excision rate of 14.6 %. In the subgroup of DCIS the re-excision rate was reduced from 61.7 to 23.1 %. In the subgroup of invasive lobular carcinomas the re-excision rate decreased from 37.0 to 19.0 %. MarginProbe© results were not affected by grading, tumor size, breast density, age, BMI or marker-wire application.

Conclusion

MarginProbe© detects positive margins in invasive carcinoma, DCIS as well as in invasive lobular carcinoma. The device decreases the re-excision rate after BCS significantly. It does not interfere with any of the factors we examined.

German guideline: www.ago-online.de

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Authors: Jens-Uwe Blohmer
Julia Tanko
Janina Kueper
Jessica Groß
Ragna Völker
Anna Machleidt
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 2/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-016-4011-3

At a glance: The STEP trials

Springer Medicine

MarginProbe© reduces the rate of re-excision following breast conserving surgery for breast cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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