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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 5/2016

01-05-2016 | General Gynecology

p53 Arg72Pro polymorphism confers the susceptibility to endometriosis among Asian and Caucasian populations

Authors: Xianjun Lao, Zhiping Chen, Aiping Qin

Published in: Archives of Gynecology and Obstetrics | Issue 5/2016

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Abstract

Purpose

Findings from studies on the association between the p53 Arg72Pro polymorphism and endometriosis susceptibility have so far been inconsistent. Therefore, we undertook a meta-analysis to clarify the association of p53 Arg72Pro polymorphism with the risk of endometriosis.

Methods

Relevant studies were chosen by searching PubMed, Embase, the Cochrane Library databases, CNKI, Wanfang database, and CBM for articles published before and up to April 30, 2015. Two independent reviewers performed the eligibility evaluation and data extraction. The odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for the overall risk estimate.

Results

Eleven case–control studies involving 1834 endometriosis cases and 2331 controls were included. Pooled data analysis suggested that the p53 72Pro variant is a significant endometriosis risk factors in comparison to the 72Arg variant (Pro vs. Arg: OR = 1.298, 95 % CI 1.082–1.558; Pro/Pro vs. Arg/Arg: OR = 1.751, 95 % CI 1.130–2.711; Pro/Arg vs. Arg/Arg: OR = 1.530, 95 % CI 1.174–1.994), which was strengthened in the dominant model (Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 1.570, 95 % CI = 1.181–2.087). In the stratified analysis by ethnicity and Hardy–Weinberg equilibrium (HWE) in the controls, we found strong associations in Asians and in studies that were consistent with HWE. However, the analyses of the revised American Fertility Society (rAFS) stage and the menopausal status subgroup did not reveal any significant associations.

Conclusion

In conclusion, the p53 Arg72Pro polymorphism was closely related to the risk of endometriosis, especially in Asian populations.
Literature
1.
Agorastos T, Masouridou S, Lambropoulos AF, Chrisafi S, Miliaras D, Pantazis K, Constantinides TC, Kotsis A, Bontis I (2004) P53 codon 72 polymorphism and correlation with ovarian and endometrial cancer in Greek women. Eur J Cancer Prev 13(4):277–280CrossRefPubMed
2.
Ammendola M, Gloria-Bottini F, Sesti F, Piccione E, Bottini E (2008) Association of p53 codon 72 polymorphism with endometriosis. Fertil Steril 90(2):406–408CrossRefPubMed
3.
Bianco B, Christofolini DM, Brandes A, Lerner TG, Goncalves-Filho RP, Souza AM, Barbosa CP (2011) Analysis of codon 72 polymorphism of the TP53 gene in infertile women with and without endometriosis. Rev Bras Ginecol Obstet 33(1):37–42CrossRefPubMed
4.
5.
6.
Bushe CJ, Bradley AJ, Wildgust HJ, Hodgson RE (2009) Schizophrenia and breast cancer incidence: a systematic review of clinical studies. Schizophr Res 114(1–3):6–16CrossRefPubMed
7.
Chang CC, Hsieh YY, Tsai FJ, Tsai CH, Tsai HD, Lin CC (2002) The proline form of p53 codon 72 polymorphism is associated with endometriosis. Fertil Steril 77(1):43–45CrossRefPubMed
8.
de Ziegler D, Borghese B, Chapron C (2010) Endometriosis and infertility: pathophysiology and management. Lancet 376(9742):730–738CrossRefPubMed
9.
10.
Dumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33(3):357–365CrossRefPubMed
11.
12.
13.
Ferrero S, Remorgida V, Maganza C, Venturini PL, Salvatore S, Papaleo E, Candiani M, Leone Roberti Maggiore U (2014) Aromatase and endometriosis: estrogens play a role. Ann N Y Acad Sci 1317:17–23CrossRefPubMed
14.
Gallegos-Arreola MP, Figuera-Villanueva LE, Puebla-Perez AM, Montoya-Fuentes H, Suarez-Rincon AE, Zuniga-Gonzalez GM (2012) Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women. Genet Mol Res 11(2):1401–1408CrossRefPubMed
15.
Gloria-Bottini F, Ammendola M, Saccucci P, Neri A, Magrini A, Bottini E (2015) The effect of ACP, ADA and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis. Arch Gynecol Obstet
16.
He XF, Su J, Zhang Y, Huang X, Liu Y, Ding DP, Wang W, Arparkorn K (2011) Association between the p53 polymorphisms and breast cancer risk: meta-analysis based on case-control study. Breast Cancer Res Treat 130(2):517–529CrossRefPubMed
17.
Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558CrossRefPubMed
18.
Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460(7259):1132–1135CrossRefPubMedPubMedCentral
19.
Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF (2004) Detection of genotyping errors by Hardy-Weinberg equilibrium testing. Eur J Hum Genet 12(5):395–399CrossRefPubMed
20.
21.
Huang Y, Zong L, Lin J, Fu Y, Liu Z, Mao T, Zeng J, Wang Y, Zhao X (2013) Association of P53 gene polymorphisms with susceptibility to endometriosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30(3):335–339PubMed
22.
Ioannidis JP, Trikalinos TA (2005) Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol 58(6):543–549CrossRefPubMed
23.
Jia S, Xu L, Chan Y, Wu X, Yang S, Yu H, Yang H, Luo Y, Tang W (2012) p53 codon 72 polymorphism and endometriosis: a meta-analysis. Arch Gynecol Obstet 285(6):1657–1661CrossRefPubMed
24.
Joerger AC, Fersht AR (2007) Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene 26(15):2226–2242CrossRefPubMed
25.
Lattuada D, Vigano P, Somigliana E, Abbiati A, Candiani M, Di Blasio AM (2004) Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis. Mol Hum Reprod 10(9):651–654CrossRefPubMed
26.
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748PubMed
27.
28.
Mitchell AA, Cutler DJ, Chakravarti A (2003) Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. Am J Hum Genet 72(3):598–610CrossRefPubMedPubMedCentral
29.
Nikbakht Dastjerdi M, Aboutorabi R, Eslami Farsani B (2013) Association of TP53 gene codon 72 polymorphism with endometriosis risk in Isfahan. Iran J Reprod Med 11(6):473–478PubMedPubMedCentral
30.
Omori S, Yoshida S, Kennedy SH, Negoro K, Hamana S, Barlow DH, Maruo T (2004) Polymorphism at codon 72 of the p53 gene is not associated with endometriosis in a Japanese population. J Soc Gynecol Investig 11(4):232–236CrossRefPubMed
31.
Piao JM, Kim HN, Song HR, Kweon SS, Choi JS, Yun WJ, Kim YC, Oh IJ, Kim KS, Shin MH (2011) p53 codon 72 polymorphism and the risk of lung cancer in a Korean population. Lung Cancer 73(3):264–267CrossRefPubMed
32.
Pim D, Banks L (2004) p53 polymorphic variants at codon 72 exert different effects on cell cycle progression. Int J Cancer 108(2):196–199CrossRefPubMed
33.
Saadat M (2011) Significance of the Hardy-Weinberg equilibrium in genetic association studies. Psychiatry Res 190(1):165CrossRefPubMed
34.
Siddique M, Sabapathy K (2006) Trp53-dependent DNA-repair is affected by the codon 72 polymorphism. Oncogene 25(25):3489–3500CrossRefPubMed
35.
Soave I, Caserta D, Wenger JM, Dessole S, Perino A, Marci R (2015) Environment and Endometriosis: a toxic relationship. Eur Rev Med Pharmacol Sci 19(11):1964–1972PubMed
36.
Song HR, Kweon SS, Kim HN, Piao JM, Yun WJ, Choi JS, Hwang JE, Yoon JY, Kim HR, Park YK, Kim SH, Choi YD, Shin MH (2011) p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population. Gastric Cancer 14(3):242–248CrossRefPubMed
37.
Szczepanska M, Wirstlein P, Holysz H, Skrzypczak J, Jagodzinski PP (2013) The FCRL3 -169T>C polymorphism and the risk of endometriosis-related infertility in a Polish population. Arch Gynecol Obstet 288(4):799–804CrossRefPubMedPubMedCentral
38.
Vietri MT, Molinari AM, Iannella I, Cioffi M, Bontempo P, Ardovino M, Scaffa C, Colacurci N, Cobellis L (2007) Arg72Pro p53 polymorphism in Italian women: no association with endometriosis. Fertil Steril 88(5):1468–1469CrossRefPubMed
39.
Ye F, Zhang J, Cheng Q, Shen J, Chen H (2010) p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population. Cancer Lett 287(1):117–121CrossRefPubMed
40.
Ying TH, Tseng CJ, Tsai SJ, Hsieh SC, Lee HZ, Hsieh YH, Bau DT (2011) Association of p53 and CDKN1A genotypes with endometriosis. Anticancer Res 31(12):4301–4306PubMed
41.
Zintzaras E (2010) Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis. Eur J Epidemiol 25(8):553–560CrossRefPubMed
Metadata
Title
p53 Arg72Pro polymorphism confers the susceptibility to endometriosis among Asian and Caucasian populations
Authors
Xianjun Lao
Zhiping Chen
Aiping Qin
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 5/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-015-3923-7

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