Top

Published in:

01-04-2016 | Maternal-Fetal Medicine

Cord blood vitamin D status and neonatal outcomes in a birth cohort in Quebec, Canada

Authors: Catherine Morgan, Linda Dodds, Donald B. Langille, Hope A. Weiler, B. Anthony Armson, Jean-Claude Forest, Yves Giguère, Christy G. Woolcott

Published in: Archives of Gynecology and Obstetrics | Issue 4/2016

Abstract

Purpose

Some evidence suggests that low maternal vitamin D status adversely affects perinatal health but few studies have examined cord blood vitamin D status. This project aimed to determine the association between the cord blood concentration of 25-hydroxyvitamin D [25(OH)D] and neonatal outcomes.

Methods

A nested case–control study was conducted in Quebec City, Canada from 2005 to 2010. Included were 83 cases of low birthweight (LBW; <2500 g), 301 cases of small for gestational age (SGA; <10th percentile), 223 cases of preterm birth (PTB; <37 weeks’ gestation), and 1027 controls. Levels of 25(OH)D were determined by chemiluminescence immunoassay. Adjusted odds ratios (OR) and 95 % confidence intervals (CI) were estimated with logistic regression.

Results

Cord blood [25(OH)D] <50 nmol/L was associated with a lower risk of LBW compared to [25(OH)D] ≥75 nmol/L (OR 0.47 95 % CI 0.23–0.97). For 25(OH)D levels 50–75 nmol/L, a significant association was not demonstrated (OR 0.58, 95 % CI 0.34–1.01). No significant associations were observed between [25(OH)D] and either SGA or PTB after adjustment.

Conclusions

Although our findings suggest that [25(OH)D] <50 nmol/L is associated with reduced risk of having a LBW infant, prenatal vitamin D recommendations require an examination of the literature that considers the full spectrum of maternal and neonatal outcomes.

Ross AC, Taylor CL, Yatkine AL, Del Valle HB, Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Institute of Medicine (2011) Dietary reference intakes for calcium and vitamin D. National Academies Press, Washington, DC

Carlberg C, Campbell MJ (2013) Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor. Steroids 78:127–136CrossRefPubMedPubMedCentral

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930CrossRefPubMed

Langlois K, Greene-Finestone L, Little J, Hidiroglou N, Whiting S (2010) Vitamin D status of Canadians as measured in the 2007–2009 Canadian Health Measures Survey. Health Rep 21:47–55PubMed

Whiting SJ, Langlois KA, Vatanparast H, Greene-Finestone LS (2011) The vitamin D status of Canadians relative to the 2011 dietary reference intakes: an examination in children and adults with and without supplement use. Am J Clin Nutr 94:128–135CrossRefPubMed

Harvey NC, Holroyd C, Ntani G et al (2014) Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess 18:1–190CrossRefPubMedCentral

Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O’Beirne M, Rabi DM (2013) Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 346:f1169CrossRefPubMed

Wei SQ, Qi HP, Luo ZC, Fraser WD (2013) Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 26:889–899CrossRefPubMed

Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig ME (2009) Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol (Oxf) 70:372–377CrossRef

10.

Burris HH, Rifas-Shiman SL, Camargo CA Jr et al (2012) Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants. Ann Epidemiol 22:581–586CrossRefPubMedPubMedCentral

11.

Dunlop AL, Taylor RN, Tangpricha V, Fortunato S, Menon R (2012) Maternal micronutrient status and preterm versus term birth for black and white US women. Reprod Sci 19:939–948CrossRefPubMedPubMedCentral

12.

Hossain N, Khanani R, Hussain-Kanani F, Shah T, Arif S, Pal L (2011) High prevalence of vitamin D deficiency in Pakistani mothers and their newborns. Int J Gynaecol Obstet 112:229–233CrossRefPubMed

13.

Thorp JM, Camargo CA, McGee PL et al (2012) Vitamin D status and recurrent preterm birth: a nested case–control study in high-risk women. BJOG 119:1617–1623CrossRefPubMedPubMedCentral

14.

Weiler H, Fitzpatrick-Wong S, Veitch R et al (2005) Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. CMAJ 172:757–761CrossRefPubMedPubMedCentral

15.

Saigal S, Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 371:261–269CrossRefPubMed

16.

McCormick MC (1985) The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 312:82–90CrossRefPubMed

17.

Longo S, Bollani L, Decembrino L, Di Comite A, Angelini M, Stronati M (2013) Short-term and long-term sequelae in intrauterine growth retardation (IUGR). J Matern Fetal Neonatal Med 26:222–225CrossRefPubMed

18.

Kramer MS, Platt RW, Wen SW et al (2001) A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics 108:E35CrossRefPubMed

19.

Wagner CL, McNeil RB, Johnson DD et al (2013) Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis. J Steroid Biochem Mol Biol 136:313–320CrossRefPubMedPubMedCentral

20.

Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S (2009) Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf) 70:685–690CrossRef

21.

Bodnar LM, Catov JM, Zmuda JM et al (2010) Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 140:999–1006CrossRefPubMedPubMedCentral

22.

Camargo CA Jr, Ingham T, Wickens K et al (2010) Vitamin D status of newborns in New Zealand. Br J Nutr 104:1051–1057CrossRefPubMed

23.

Holmes VA, Barnes MS, Alexander HD, McFaul P, Wallace JM (2009) Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 102:876–881CrossRefPubMed

24.

Ozias MK, Kerling EH, Christifano DN, Scholtz SA, Colombo J, Carlson SE (2014) Typical prenatal vitamin D supplement intake does not prevent decrease of plasma 25-hydroxyvitamin d at birth. J Am Coll Nutr 33:394–399CrossRefPubMedPubMedCentral

25.

Milman N, Hvas AM, Bergholt T (2011) Vitamin D status during normal pregnancy and postpartum: a longitudinal study in 141 Danish women. J Perinat Med 40:57–61PubMed

26.

Bodnar LM, Catov JM, Wisner KL, Klebanoff MA (2009) Racial and seasonal differences in 25-hydroxyvitamin D detected in maternal sera frozen for over 40 years. Br J Nutr 101:278–284CrossRefPubMedPubMedCentral

27.

Marwaha RK, Tandon N, Chopra S et al (2011) Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels. Br J Nutr 106:1383–1389CrossRefPubMed

28.

Public Health Agency of Canada (2008) Canadian Perinatal Health Report 2008 Edition. Ottawa

29.

Auger N, Giraud J, Daniel M (2009) The joint influence of area income, income inequality, and immigrant density on adverse birth outcomes: a population-based study. BMC Public Health 9:237CrossRefPubMedPubMedCentral

30.

Davies GA, Wolfe LA, Mottola MF, MacKinnon C (2003) Joint SOGC/CSEP clinical practice guideline: exercise in pregnancy and the postpartum period. Can J Appl Physiol 28:330–341CrossRefPubMed

Title: Cord blood vitamin D status and neonatal outcomes in a birth cohort in Quebec, Canada
Authors: Catherine Morgan
Linda Dodds
Donald B. Langille
Hope A. Weiler
B. Anthony Armson
Jean-Claude Forest
Yves Giguère
Christy G. Woolcott
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2016
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3899-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cord blood vitamin D status and neonatal outcomes in a birth cohort in Quebec, Canada

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2016

Predictors for a successful external cephalic version: a single centre experience

Metabolic syndrome in Greek women with polycystic ovary syndrome: prevalence, characteristics and associations with body mass index. A prospective controlled study

Therapeutic effects of uterine artery embolisation (UAE) and methotrexate (MTX) conservative therapy used in treatment of cesarean scar pregnancy

Propranolol and oxytocin versus oxytocin alone for induction and augmentation of labor: a meta-analysis of randomized trials

Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis

Agreement between the preoperative findings and the operative diagnosis in patients with deep endometriosis