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Archives of Gynecology and Obstetrics

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01-06-2015 | Review

Very late recurrence (after more than 20 years) of epithelial ovarian carcinoma: case report and literature review

Authors: Joseph Menczer, Letizia Schreiber, Ofri Peled, Tally Levy

Published in: Archives of Gynecology and Obstetrics | Issue 6/2015

Abstract

Purpose

To present a case of very late (more than 20 years) recurrence of epithelial ovarian carcinoma and to review the pertinent literature. We encountered a 50-year-old patient who, at the age of 22, underwent cytoreductive surgery and adjuvant chemotherapy for stage III serous ovarian carcinoma. She recurred after 28 years and underwent secondary surgery and chemotherapy.

Method

A PubMed search of the English literature containing the following key words: ovarian cancer, late recurrence, late relapse, late metastasis was performed.

Results

Only five cases (including the present one) with recurrence after more than 20 years are so far on record. Of these, four patients were 33 years old or younger and had advanced stage at diagnosis. Time to recurrence ranged from 21 to 28 years. All patients had serous carcinoma and three had recurrence in lymph nodes.

Conclusions

Very late recurrence is an extremely rare event and may result from either regrowth of dormant tumor cells or from development of a new cancer. Lifelong follow-up is critically important for ovarian cancer patients.

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Title: Very late recurrence (after more than 20 years) of epithelial ovarian carcinoma: case report and literature review
Authors: Joseph Menczer
Letizia Schreiber
Ofri Peled
Tally Levy
Publication date: 01-06-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 6/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3597-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Very late recurrence (after more than 20 years) of epithelial ovarian carcinoma: case report and literature review

Abstract

Purpose

Method

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusions

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