Skip to main content
Top
Published in: Archives of Gynecology and Obstetrics 4/2015

01-04-2015 | Maternal-Fetal Medicine

Strain elastography in placental dysfunction: placental elasticity differences in normal and preeclamptic pregnancies in the second trimester

Authors: Canan Cimsit, Tevfik Yoldemir, Ihsan Nuri Akpinar

Published in: Archives of Gynecology and Obstetrics | Issue 4/2015

Login to get access

Abstract

Purpose

The aim of this study is to determine if the Strain elastography (SE) of the placenta measured in the second trimester differs between normal pregnancies and pregnancies complicated by preeclampsia (PE).

Methods

219 singleton pregnancies who had routine anomaly scanning between the 20th and 23rd weeks of gestation were included in this observational study. Women with either posterior placentations (n = 63) or other obstetric pathologies (n = 12) were excluded from the study, leaving 144 pregnant women for the evaluation of strain ratio with SE. One hundred and one women with normal pregnancies and normal deliveries without any perinatal complications formed Group A. Twenty-eight patients who were clinically diagnosed with early onset PE before anomaly scanning formed Group B. Fifteen normotensive pregnant women with either mild proteinuria, and past history of preeclampsia during their previous pregnancies formed Group C. The strain ratios were compared between the groups.

Results

The strain ratio of Group B was significantly higher than those of Group A and Group C (p < 0.05).

Conclusions

The placental elasticity ratios measured by SE imaging during the second trimester differ between the normal pregnancies and the pregnancies complicated by PE. SE might be used as a supplement tool in addition to the existing methods for the prediction of PE.
Literature
1.
go back to reference Kauer M, Vuskovic V, Dual J, Szekely G, Bajka M (2002) Inverse finite element characterization of soft tissues. Med Image Anal 6(3):275–287CrossRefPubMed Kauer M, Vuskovic V, Dual J, Szekely G, Bajka M (2002) Inverse finite element characterization of soft tissues. Med Image Anal 6(3):275–287CrossRefPubMed
3.
go back to reference Tan S, Ozcan MF, Tezcan F, Balci S, Karaoğlanoğlu M, Huddam B, Arslan H (2013) Real-time elastography for distinguishing angiomyolipoma from renal cell carcinoma: preliminary observations. AJR Am J Roentgenol 200(4):W369–W375CrossRefPubMed Tan S, Ozcan MF, Tezcan F, Balci S, Karaoğlanoğlu M, Huddam B, Arslan H (2013) Real-time elastography for distinguishing angiomyolipoma from renal cell carcinoma: preliminary observations. AJR Am J Roentgenol 200(4):W369–W375CrossRefPubMed
4.
go back to reference Arda K, Ciledag N, Gumusdag P (2010) Differential diagnosis of malignant cervical lymph nodes at real-time ultrasonographic elastography and Doppler ultrasonography. Hung Radiol Online 6:12–15 Arda K, Ciledag N, Gumusdag P (2010) Differential diagnosis of malignant cervical lymph nodes at real-time ultrasonographic elastography and Doppler ultrasonography. Hung Radiol Online 6:12–15
5.
go back to reference Friedrich-Rust M, Ong MF, Herrmann E, Dries V, Samaras P, Zeuzem S, Sarrazin C (2007) Real-time elastography for noninvasive assessment of liver fibrosis in chronic viral hepatitis. AJR Am J Roentgenol 188(3):758–764CrossRefPubMed Friedrich-Rust M, Ong MF, Herrmann E, Dries V, Samaras P, Zeuzem S, Sarrazin C (2007) Real-time elastography for noninvasive assessment of liver fibrosis in chronic viral hepatitis. AJR Am J Roentgenol 188(3):758–764CrossRefPubMed
6.
go back to reference Itoh A, Ueno E, Tohno E, Kamma H, Takahashi H, Shiina T, Yamakawa M, Matsumura T (2006) Breast disease: clinical application of US elastography for diagnosis. Radiology 239:341–350CrossRefPubMed Itoh A, Ueno E, Tohno E, Kamma H, Takahashi H, Shiina T, Yamakawa M, Matsumura T (2006) Breast disease: clinical application of US elastography for diagnosis. Radiology 239:341–350CrossRefPubMed
7.
go back to reference Trimboli P, Guglielmi R, Monti S et al (2012) Ultrasound sensitivity for thyroid malignancy is increased by real-time elastography: a prospective multicenter study. J Clin Endocrinol Metab 97(12):4524–4530CrossRefPubMed Trimboli P, Guglielmi R, Monti S et al (2012) Ultrasound sensitivity for thyroid malignancy is increased by real-time elastography: a prospective multicenter study. J Clin Endocrinol Metab 97(12):4524–4530CrossRefPubMed
8.
go back to reference König K, Scheipers U, Pesavento A, Lorenz A, Ermert H, Senge T (2005) Initial experiences with real-time elastography guided biopsies of the prostate. J Urol 174:115–117CrossRefPubMed König K, Scheipers U, Pesavento A, Lorenz A, Ermert H, Senge T (2005) Initial experiences with real-time elastography guided biopsies of the prostate. J Urol 174:115–117CrossRefPubMed
10.
go back to reference Giovannini M, Botelberge T, Bories E et al (2009) Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study. World J Gastroenterol 15:1587–1593CrossRefPubMedCentralPubMed Giovannini M, Botelberge T, Bories E et al (2009) Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study. World J Gastroenterol 15:1587–1593CrossRefPubMedCentralPubMed
11.
go back to reference Stoelinga B, Hehenkamp WJ, Brölmann HA, Huirne JA (2014) The use of real-time elastography in the assessment of uterine disorders. Ultrasound Obstet Gynecol 43(2):218–226CrossRefPubMed Stoelinga B, Hehenkamp WJ, Brölmann HA, Huirne JA (2014) The use of real-time elastography in the assessment of uterine disorders. Ultrasound Obstet Gynecol 43(2):218–226CrossRefPubMed
12.
go back to reference Fuchs T, Pomorski M, Zimmer M (2013) Quantitative cervical elastography in pregnancy. Ultrasound Obstet Gynecol 41(6):712CrossRefPubMed Fuchs T, Pomorski M, Zimmer M (2013) Quantitative cervical elastography in pregnancy. Ultrasound Obstet Gynecol 41(6):712CrossRefPubMed
13.
go back to reference Yu CK, Khouri O, Onwudiwe N, Spiliopoulos Y, Nicolaides KH, Fetal Medicine Foundation Second-Trimester Screening Group (2008) Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age. Ultrasound Obstet Gynecol 31(3):310–313CrossRefPubMed Yu CK, Khouri O, Onwudiwe N, Spiliopoulos Y, Nicolaides KH, Fetal Medicine Foundation Second-Trimester Screening Group (2008) Prediction of pre-eclampsia by uterine artery Doppler imaging: relationship to gestational age at delivery and small-for-gestational age. Ultrasound Obstet Gynecol 31(3):310–313CrossRefPubMed
14.
go back to reference Murphy DJ, Striate GM (2000) Mortality and morbidity associated with early-onset preeclampsia. Hypertens Pregnancy 19:221–231CrossRefPubMed Murphy DJ, Striate GM (2000) Mortality and morbidity associated with early-onset preeclampsia. Hypertens Pregnancy 19:221–231CrossRefPubMed
15.
go back to reference Valensise H, Vasapollo B, Gagliardi G, Novelli GP (2008) Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 52(5):873–880CrossRefPubMed Valensise H, Vasapollo B, Gagliardi G, Novelli GP (2008) Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease. Hypertension 52(5):873–880CrossRefPubMed
16.
go back to reference Harrington K, Cooper D, Lees C, Hecher K, Campbell S (1996) Doppler ultrasound of the uterine arteries: the importance of bilateral notching in the prediction of pre-eclampsia, placental abruption or delivery of a small-for-gestational-age baby. Ultrasound Obstet Gynecol 7(3):182–188CrossRefPubMed Harrington K, Cooper D, Lees C, Hecher K, Campbell S (1996) Doppler ultrasound of the uterine arteries: the importance of bilateral notching in the prediction of pre-eclampsia, placental abruption or delivery of a small-for-gestational-age baby. Ultrasound Obstet Gynecol 7(3):182–188CrossRefPubMed
17.
go back to reference Grill S, Rusterholz C, Zanetti-Dällenbach R, Tercanli S, Holzgreve W, Hahn S, Lapaire O (2009) Potential markers of preeclampsia—a review. Reprod Biol Endocrinol 14(7):70CrossRef Grill S, Rusterholz C, Zanetti-Dällenbach R, Tercanli S, Holzgreve W, Hahn S, Lapaire O (2009) Potential markers of preeclampsia—a review. Reprod Biol Endocrinol 14(7):70CrossRef
18.
go back to reference Hladunewich M, Karumanchi SA, Lafayette R (2007) Pathophysiology of the clinical manifestations of preeclampsia. Clin J Am Soc Nephrol 2(3):543–549CrossRefPubMed Hladunewich M, Karumanchi SA, Lafayette R (2007) Pathophysiology of the clinical manifestations of preeclampsia. Clin J Am Soc Nephrol 2(3):543–549CrossRefPubMed
19.
go back to reference Li WJ, Wei ZT, Yan RL, Zhang YL (2012) Detection of placenta elasticity modulus by quantitative real-time shear wave imaging. Clin Exp Obstet Gynecol 39(4):470–473PubMed Li WJ, Wei ZT, Yan RL, Zhang YL (2012) Detection of placenta elasticity modulus by quantitative real-time shear wave imaging. Clin Exp Obstet Gynecol 39(4):470–473PubMed
20.
go back to reference Sugitani M, Fujita Y, Yumoto Y, Fukushima K, Takeuchi T, Shimokawa M, Kato K (2013) A new method for measurement of placental elasticity: acoustic radiation force impulse imaging. Placenta 34(11):1009–1013CrossRefPubMed Sugitani M, Fujita Y, Yumoto Y, Fukushima K, Takeuchi T, Shimokawa M, Kato K (2013) A new method for measurement of placental elasticity: acoustic radiation force impulse imaging. Placenta 34(11):1009–1013CrossRefPubMed
21.
go back to reference Frey H (2003) Real-time elastography: a new ultrasound procedure for the reconstruction of tissue elasticity. Radiology 43:850–855CrossRef Frey H (2003) Real-time elastography: a new ultrasound procedure for the reconstruction of tissue elasticity. Radiology 43:850–855CrossRef
22.
go back to reference Srinivasan S, Kallel F, Ophir J (2002) The effects of digitization on the elastographic signal-to-noise ratio. Ultrasound Med Biol 28:1521–1534CrossRefPubMed Srinivasan S, Kallel F, Ophir J (2002) The effects of digitization on the elastographic signal-to-noise ratio. Ultrasound Med Biol 28:1521–1534CrossRefPubMed
23.
go back to reference Bamber J, Cosgrove D, Dietrich CF et al (2013) EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: basic principles and technology. Ultraschall Med 34(2):169–184CrossRefPubMed Bamber J, Cosgrove D, Dietrich CF et al (2013) EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: basic principles and technology. Ultraschall Med 34(2):169–184CrossRefPubMed
24.
go back to reference Papageorghiou AT, Yu CK, Nicolaides KH (2004) The role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol 18(3):383–396CrossRefPubMed Papageorghiou AT, Yu CK, Nicolaides KH (2004) The role of uterine artery Doppler in predicting adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol 18(3):383–396CrossRefPubMed
25.
go back to reference Cnossen JS, Morris RK, ter Riet G et al (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 178(6):701–711CrossRefPubMedCentralPubMed Cnossen JS, Morris RK, ter Riet G et al (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 178(6):701–711CrossRefPubMedCentralPubMed
26.
go back to reference Espinoza J, Kusanovic JP, Bahado-Singh R et al (2010) Should bilateral uterine artery notching be used in the risk assessment for preeclampsia, small-for-gestational-age, and gestational hypertension? J Ultrasound Med 29(7):1103–1115PubMedCentralPubMed Espinoza J, Kusanovic JP, Bahado-Singh R et al (2010) Should bilateral uterine artery notching be used in the risk assessment for preeclampsia, small-for-gestational-age, and gestational hypertension? J Ultrasound Med 29(7):1103–1115PubMedCentralPubMed
27.
go back to reference Papageorghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KH (2001) Multicenter screening for preeclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18(5):441–449CrossRefPubMed Papageorghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KH (2001) Multicenter screening for preeclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18(5):441–449CrossRefPubMed
28.
go back to reference Conde-Agudelo A, Villar J, Lindheimer M (2004) World Health Organization systematic review of screening tests for preeclampsia. Obstet Gynecol 104:1367–1391CrossRefPubMed Conde-Agudelo A, Villar J, Lindheimer M (2004) World Health Organization systematic review of screening tests for preeclampsia. Obstet Gynecol 104:1367–1391CrossRefPubMed
29.
go back to reference Schulman H, Fleischer A, Farmakides G, Bracero L, Rochelson B, Grunfeld L (1986) Development of uterine artery compliance in pregnancy as detected by Doppler ultrasound. Am J Obstet Gynecol 155:1031–1036CrossRefPubMed Schulman H, Fleischer A, Farmakides G, Bracero L, Rochelson B, Grunfeld L (1986) Development of uterine artery compliance in pregnancy as detected by Doppler ultrasound. Am J Obstet Gynecol 155:1031–1036CrossRefPubMed
30.
go back to reference Hernández-Díaz S, Toh S, Cnattingius S (2009) Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ 8(338):b2255CrossRef Hernández-Díaz S, Toh S, Cnattingius S (2009) Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ 8(338):b2255CrossRef
32.
go back to reference Nelson DB, Ziadie, McIntire DD, Rogers BB, Leveno KJ (2014) Placental pathology suggesting that preeclampsia is more than one disease. J Am J Obstet Gynecol 210(1):66.e1–7 Nelson DB, Ziadie, McIntire DD, Rogers BB, Leveno KJ (2014) Placental pathology suggesting that preeclampsia is more than one disease. J Am J Obstet Gynecol 210(1):66.e1–7
33.
go back to reference Vinnars MT, Nasiell J, Ghazi S, Westgren M, Papadogiannakis N (2011) The severity of clinical manifestations in preeclampsia correlates with the amount of placental infarction. Acta Obstet Gynecol Scand 90(1):19–25CrossRefPubMed Vinnars MT, Nasiell J, Ghazi S, Westgren M, Papadogiannakis N (2011) The severity of clinical manifestations in preeclampsia correlates with the amount of placental infarction. Acta Obstet Gynecol Scand 90(1):19–25CrossRefPubMed
34.
go back to reference Dietrich CF, Hirche TO, Ott M, Ignee A (2009) Real-time tissue elastography in the diagnosis of autoimmune pancreatitis. Endoscopy 41(8):718–720CrossRefPubMed Dietrich CF, Hirche TO, Ott M, Ignee A (2009) Real-time tissue elastography in the diagnosis of autoimmune pancreatitis. Endoscopy 41(8):718–720CrossRefPubMed
Metadata
Title
Strain elastography in placental dysfunction: placental elasticity differences in normal and preeclamptic pregnancies in the second trimester
Authors
Canan Cimsit
Tevfik Yoldemir
Ihsan Nuri Akpinar
Publication date
01-04-2015
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-014-3479-y

Other articles of this Issue 4/2015

Archives of Gynecology and Obstetrics 4/2015 Go to the issue