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Archives of Gynecology and Obstetrics

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01-04-2015 | Maternal-Fetal Medicine

Second trimester amniotic fluid retinol in patients developing preeclampsia

Authors: A. Fruscalzo, A. P. Londero, J. Biasizzo, N. Bortolotti, S. Bertozzi, F. Curcio, D. Marchesoni, L. Driul

Published in: Archives of Gynecology and Obstetrics | Issue 4/2015

Abstract

Background

Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes.

Objective

To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF).

Materials and methods

Case–control study comparing the concentration of ROH and other antioxidants such as uric acid, vitamin E and malondialdehyde (MDA) in second trimester AF in patients that later developed preeclampsia with normal pregnancies.

Results

The concentration of ROH in amniotic fluids of women that later developed preeclampsia was significantly higher than those of uncomplicated pregnancies (66.72 µg/l (49.00–70.56) vs. 44.4 µg/l (31.9–51.17), p < 0.05). No statistical significant difference was found in uric acid, vitamin E and MDA concentration. In the multivariate logistic regression, concentrations of ROH in amniotic fluids directly correlate with the risk of developing preeclampsia (OR 1.13, IC 0.01–1.26, p < 0.05).

Conclusions

Second trimester AF ROH concentration was significantly higher in pregnancies that developed preeclampsia compared to normal pregnancies.

Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365:785–799CrossRefPubMed

Genc H, Uzun H, Benian A et al (2011) Evaluation of oxidative stress markers in first trimester for assessment of preeclampsia risk. Arch Gynecol Obstet 284:1367–1373CrossRefPubMed

Siddiqui IA, Jaleel A, Tamimi W, Al Kadri HM (2010) Role of oxidative stress in the pathogenesis of preeclampsia. Arch Gynecol Obstet 282:469–474CrossRefPubMed

Lee R, Margaritis M, Channon KM, Antoniades C (2012) Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Curr Med Chem 19:2504–2520CrossRefPubMedCentralPubMed

Kaufmann P, Black S, Huppertz B (2003) Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod 69:1–7CrossRefPubMed

Cudihy D, Lee RV (2009) The pathophysiology of pre-eclampsia: current clinical concepts. J Obstet Gynaecol 29:576–582CrossRefPubMed

Modena AB, Fieni S (2004) Amniotic fluid dynamics. Acta Biomed 75(Suppl 1):11–13PubMed

Romero FJ, Bosch-Morell F, Romero MJ et al (1998) Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 106(Suppl 5):1229–1234CrossRefPubMedCentralPubMed

Il’yasova D, Scarbrough P, Spasojevic I (2012) Urinary biomarkers of oxidative status. Clinica Chimica Acta 413:1446–1453CrossRef

10.

Jin M, Yang F, Yang I et al (2012) Uric acid, hyperuricemia and vascular diseases. Front Biosci 17:656–669CrossRef

11.

Colombo ML (2010) An update on vitamin E, tocopherol and tocotrienol-perspectives. Molecules 15:2103–2113CrossRefPubMed

12.

Saremi A, Arora R (2010) Vitamin E and cardiovascular disease. Am J Ther 17:e56–e65CrossRefPubMed

13.

Russell RM (2000) The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 71:878–884PubMed

14.

Spiegler E, Kim YK, Wassef L, Shete V, Quadro L (2012) Maternal-fetal transfer and metabolism of vitamin A and its precursor beta-carotene in the developing tissues. Biochim Biophys Acta 1821:88–98CrossRefPubMedCentralPubMed

15.

Zanotti G, Berni R (2004) Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin. Vitam Horm 69:271–295CrossRefPubMed

16.

Fruscalzo A, Schmitz R, Klockenbusch W et al (2012) Human placental transthyretin in fetal growth restriction in combination with preeclampsia and the HELLP syndrome. Histochem Cell Biol 138:925–932CrossRefPubMed

17.

Fruscalzo A, Biasioli A, Londero AP et al (2013) Retinol binding protein as early marker of fetal growth restriction in first trimester maternal serum. Gynecol Endocrinol 29(4):323–326CrossRefPubMed

18.

Pecks U, Seidenspinner F, Rower C, Reimer T, Rath W, Glocker MO (2010) Multifactorial analysis of affinity-mass spectrometry data from serum protein samples: a strategy to distinguish patients with preeclampsia from matching control individuals. J Am Soc Mass Spectrom 21:1699–1711CrossRefPubMed

19.

Vascotto C, Salzano AM, D’Ambrosio C et al (2007) Oxidized transthyretin in amniotic fluid as an early marker of preeclampsia. J Proteome Res 6:160–170CrossRefPubMed

20.

Raghu P, Sivakumar B (2004) Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis. Biochim Biophys Acta 1703:1–9CrossRefPubMed

21.

Londero AP, Bertozzi S, Visentin S, Fruscalzo A, Driul L, Marchesoni D (2013) High placental index and poor pregnancy outcomes: a retrospective study of 18 386 pregnancies. Gynecol Endocrinol 29:666–669CrossRefPubMed

22.

Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM (2001) The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the international society for the study of hypertension in pregnancy (ISSHP). Hypertens Pregnancy 20:9–14CrossRef

23.

Fruscalzo A, Bertozzi S, Londero AP et al (2010) Menstrual abnormalities and predisposition to pregnancy-related hypertensive disorders: a retrospective study. Gynecol Endocrinol 26(6):445–450CrossRefPubMed

24.

Campbell J, Wathen NC, Merryweather I, Abbott R, Muller D, Chard T (1994) Concentrations of vitamins A and E in amniotic fluid, extraembryonic coelomic fluid, and maternal serum in the first trimester of pregnancy. Arch Dis Child Fetal Neonatal Ed 71:F49–F50CrossRefPubMedCentralPubMed

25.

Uotila J, Tuimala R, Pyykko K, Ahotupa M (1993) Pregnancy-induced hypertension is associated with changes in maternal and umbilical blood antioxidants. Gynecol Obstet Invest 36:153–157CrossRefPubMed

26.

Panburana P, Phuapradit W, Puchaiwatananon O (2000) Antioxidant nutrients and lipid peroxide levels in Thai preeclamptic pregnant women. J Obstet Gynaecol Res 26:377–381CrossRefPubMed

27.

Jendryczko A, Drozdz M (1989) Plasma retinol, beta-carotene and vitamin E levels in relation to the future risk of pre-eclampsia. Zentralbl Gynakol 111:1121–1123PubMed

28.

Kim YH, Kim CH, Cho MK et al (2006) Total peroxyl radical-trapping ability and anti-oxidant vitamins of the umbilical venous plasma and the placenta in pre-eclampsia. J Obstet Gynaecol Res 32:32–41CrossRefPubMed

29.

Zhang C, Williams MA, Sanchez SE et al (2001) Plasma concentrations of carotenoids, retinol, and tocopherols in preeclamptic and normotensive pregnant women. Am J Epidemiol 153:572–580CrossRefPubMed

30.

Mikhail MS, Anyaegbunam A, Garfinkel D, Palan PR, Basu J, Romney SL (1994) Preeclampsia and antioxidant nutrients: decreased plasma levels of reduced ascorbic acid, alpha-tocopherol, and beta-carotene in women with preeclampsia. Am J Obstet Gynecol 171:150–157CrossRefPubMed

31.

Akyol D, Mungan T, Gorkemli H, Nuhoglu G (2000) Maternal levels of vitamin E in normal and preeclamptic pregnancy. Arch Gynecol Obstet 263:151–155CrossRefPubMed

32.

Wallingford JC, Milunsky A, Underwood BA (1983) Vitamin A and retinol-binding protein in amniotic fluid. Am J Clin Nutr 38:377–381PubMed

33.

Sklan D, Shalit I, Lasebnik N, Spirer Z, Weisman Y (1985) Retinol transport proteins and concentrations in human amniotic fluid, placenta, and fetal and maternal sera. Br J Nutr 54:577–583CrossRefPubMed

34.

Koskinen T, Valtonen P, Lehtovaara I, Tuimala R (1986) Amniotic fluid retinol concentrations in late pregnancy. Biol Neonate 49:81–84CrossRefPubMed

35.

Gao T, Zablith NR, Burns DH, Skinner CD, Koski KG (2008) Second trimester amniotic fluid transferrin and uric acid predict infant birth outcomes. Prenat Diagn 28:810–814CrossRefPubMed

36.

Anderson D, Yang Q, Hohimer A, Faber J, Giraud G, Davis L (2005) Intramembranous absorption rate is unaffected by changes in amniotic fluid composition. Am J Physiol Renal Physiol 288:F964–F968CrossRefPubMed

37.

Jauniaux E, Gulbis B (2000) Fluid compartments of the embryonic environment. Hum Reprod Update 6:268–278CrossRefPubMed

38.

Raila J, Wirth K, Chen F, Buscher U, Dudenhausen JW, Schweigert FJ (2004) Excretion of vitamin A in urine of women during normal pregnancy and pregnancy complications. Ann Nutr Metab 48:357–364CrossRefPubMed

Title: Second trimester amniotic fluid retinol in patients developing preeclampsia
Authors: A. Fruscalzo
A. P. Londero
J. Biasizzo
N. Bortolotti
S. Bertozzi
F. Curcio
D. Marchesoni
L. Driul
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3477-0

At a glance: The STEP trials

Springer Medicine

Second trimester amniotic fluid retinol in patients developing preeclampsia

Abstract

Background

Objective

Materials and methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusions

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