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Archives of Gynecology and Obstetrics

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01-04-2015 | Maternal-Fetal Medicine

Serotonin risk factors for the development of hypertension in pregnancy

Authors: Senka Sabolovic Rudman, Maja Mustapic, Vesna Kosec, Nela Pivac, Franjo Rudman, Dorotea Muck-Seler

Published in: Archives of Gynecology and Obstetrics | Issue 4/2015

Abstract

Purpose

To determine platelet serotonin (5-HT) concentrations and genotype and allele frequencies of serotonergic type 2A receptor gene (HTR2A) and 5-HT transporter gene (SLC6A4) in women with pre-eclampsia, gestational hypertension without proteinuria (PIH) and in control normotensive pregnant women.

Methods

The study included 96 control women, 131 women with PIH and 84 women with pre-eclampsia (ICD-10 criteria) in the last trimester of pregnancy. Variants of the HTR2A T102C (rs6313) and SLC6A4 (5-HTTLPR and rs25531) were determined by the PCR and real-time PCR procedures. Platelet 5-HT concentrations were analyzed by the spectrofluorimetric method.

Results

The frequency of the 5HTTLPR and of HTR2A T102C genotypes or alleles was similar between three groups of pregnant women and was not associated with low platelet 5-HT concentrations observed in pregnant women with PIH or pre-eclampsia.

Conclusions

The results confirm alterations in the peripheral 5-HT system in pregnancy-induced hypertension. Low platelet 5-HT concentration is a common feature of both PIH and pre-eclampsia. The results did not support the hypothesis that hypertension in pregnancy is a trait associated with polymorphic variants of the HTR2A and SLC6A4 or that they have a role in the predisposition to hypertensive disorders in pregnancy. The further studies are necessary to elucidate the role of 5-HT and genetic factors in the development of hypertensive disorders in pregnancy.

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Title: Serotonin risk factors for the development of hypertension in pregnancy
Authors: Senka Sabolovic Rudman
Maja Mustapic
Vesna Kosec
Nela Pivac
Franjo Rudman
Dorotea Muck-Seler
Publication date: 01-04-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3461-8

At a glance: The STEP trials

Springer Medicine

Serotonin risk factors for the development of hypertension in pregnancy

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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