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Published in: Archives of Gynecology and Obstetrics 6/2014

01-06-2014 | General Gynecology

Diagnosis of pelvic inflammatory disease (PID): intra-operative findings and comparison of vaginal and intra-abdominal cultures

Authors: Christian Schindlbeck, Dominik Dziura, Ioannis Mylonas

Published in: Archives of Gynecology and Obstetrics | Issue 6/2014

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Abstract

Introduction

Pelvic inflammatory disease (PID) is frequent in adolescents and younger women. Diagnosis is usually based on the clinical findings, and the threshold for empiric antibiotic therapy should be low. However, at least in cases of resistance toward therapy or deterioration of symptoms, laparoscopic evaluation can be helpful.

Methods

We searched the hospital charts for in-house patients who were treated for PID or tubo-ovarian abscess between 2007 and 2010. In cases with both vaginal and intra-abdominal bacterial cultures, results of those were compared.

Results

73 patients with suspected PID or tubo-ovarian abscess were included. Median patients’ age was 40 years (18–88), 18 of 73 (24.7 %) patients had an IUD at the time of consultation. 58 patients underwent laparoscopy or laparotomy. In 41 patients (70.7 %) tubo-ovarian abscess could be confirmed, four patients had differential gynecologic diagnoses, and two patients appendicitis. In vaginal swabs, most frequent bacteria were Streptococcus sp. (28.5 %), Escherichia coli (22.2 %), Enterococcus faecalis (15.9 %), and Staphylococcus sp. (9.5 %). In eight patients (11 %) Chlamydia trachomatis could be found, there was no case of Neisseria gonorrhea. In 33 patients both vaginal and abdominal cultures were available. In nine cases (27.3 %), identical bacteria could be found, however, 11 cases (33.3 %) showed different results.

Conclusion

In severe cases of PID, laparoscopic evaluation and taking an intra-abdominal bacterial culture are helpful for the confirmation of diagnosis, accurate microbiologic testing and specific therapy.
Literature
1.
go back to reference Workowski KA, Berman S (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 59:1–110PubMed Workowski KA, Berman S (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 59:1–110PubMed
2.
go back to reference Oroz C, Bailey H, Hollows K, Lee J, Mullan H, Theobald N (2012) A national audit on the management of pelvic inflammatory disease in UK genitourinary medicine clinics. Int J STD AIDS 23:53–54PubMedCrossRef Oroz C, Bailey H, Hollows K, Lee J, Mullan H, Theobald N (2012) A national audit on the management of pelvic inflammatory disease in UK genitourinary medicine clinics. Int J STD AIDS 23:53–54PubMedCrossRef
3.
go back to reference Westrom L, Joesoef R, Reynolds G, Hagdu A, Thompson SE (1992) Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex Transm Dis 19:185–192PubMedCrossRef Westrom L, Joesoef R, Reynolds G, Hagdu A, Thompson SE (1992) Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex Transm Dis 19:185–192PubMedCrossRef
4.
go back to reference Mylonas I (2012) Female genital Chlamydia trachomatis infection: where are we heading? Arch Gynecol Obstet 285:1271–1285PubMedCrossRef Mylonas I (2012) Female genital Chlamydia trachomatis infection: where are we heading? Arch Gynecol Obstet 285:1271–1285PubMedCrossRef
5.
go back to reference WHO (2005) Sexually transmitted diseases and other reproductive tract infections: a guide to essential practice WHO (2005) Sexually transmitted diseases and other reproductive tract infections: a guide to essential practice
6.
go back to reference Mylonas I, Friese K (2009) Adnexitis—a clinical challenge. Der Gynakol 42:786–792CrossRef Mylonas I, Friese K (2009) Adnexitis—a clinical challenge. Der Gynakol 42:786–792CrossRef
7.
go back to reference Henry-Suchet J, Tesquier L (1994) Role of laparoscopy in the management of pelvic adhesions and pelvic sepsis. Baillieres Clin Obstet Gynaecol 8:759–772PubMedCrossRef Henry-Suchet J, Tesquier L (1994) Role of laparoscopy in the management of pelvic adhesions and pelvic sepsis. Baillieres Clin Obstet Gynaecol 8:759–772PubMedCrossRef
8.
go back to reference Morino M, Pellegrino L, Castagna E, Farinella E, Mao P (2006) Acute nonspecific abdominal pain: a randomized, controlled trial comparing early laparoscopy versus clinical observation. Ann Surg 244:881–886 (discussion 886–888) Morino M, Pellegrino L, Castagna E, Farinella E, Mao P (2006) Acute nonspecific abdominal pain: a randomized, controlled trial comparing early laparoscopy versus clinical observation. Ann Surg 244:881–886 (discussion 886–888)
9.
go back to reference Peipert JF, Ness RB, Blume J, Soper DE, Holley R, Randall H, Sweet RL, Sondheimer SJ, Hendrix SL, Amortegui A, Trucco G, Bass DC (2001) Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease. Am J Obstet Gynecol 184:856–863 (discussion 863–854) Peipert JF, Ness RB, Blume J, Soper DE, Holley R, Randall H, Sweet RL, Sondheimer SJ, Hendrix SL, Amortegui A, Trucco G, Bass DC (2001) Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease. Am J Obstet Gynecol 184:856–863 (discussion 863–854)
10.
go back to reference Peipert JF, Boardman L, Hogan JW, Sung J, Mayer KH (1996) Laboratory evaluation of acute upper genital tract infection. Obstet Gynecol 87:730–736PubMedCrossRef Peipert JF, Boardman L, Hogan JW, Sung J, Mayer KH (1996) Laboratory evaluation of acute upper genital tract infection. Obstet Gynecol 87:730–736PubMedCrossRef
11.
go back to reference Demirtas O, Akman L, Demirtas GS, Hursitoglu BS, Yilmaz H (2013) The role of the serum inflammatory markers for predicting the tubo-ovarian abscess in acute pelvic inflammatory disease: a single-center 5-year experience. Arch Gynecol Obstet 287:519–523PubMedCrossRef Demirtas O, Akman L, Demirtas GS, Hursitoglu BS, Yilmaz H (2013) The role of the serum inflammatory markers for predicting the tubo-ovarian abscess in acute pelvic inflammatory disease: a single-center 5-year experience. Arch Gynecol Obstet 287:519–523PubMedCrossRef
12.
go back to reference Gaitan H, Angel E, Diaz R, Parada A, Sanchez L, Vargas C (2002) Accuracy of five different diagnostic techniques in mild-to-moderate pelvic inflammatory disease. Infect Dis Obstet Gynecol 10:171–180PubMedCentralPubMedCrossRef Gaitan H, Angel E, Diaz R, Parada A, Sanchez L, Vargas C (2002) Accuracy of five different diagnostic techniques in mild-to-moderate pelvic inflammatory disease. Infect Dis Obstet Gynecol 10:171–180PubMedCentralPubMedCrossRef
13.
go back to reference Jacobson L, Westrom L (1969) Objectivized diagnosis of acute pelvic inflammatory disease. Diagnostic and prognostic value of routine laparoscopy. Am J Obstet Gynecol 105:1088–1098PubMed Jacobson L, Westrom L (1969) Objectivized diagnosis of acute pelvic inflammatory disease. Diagnostic and prognostic value of routine laparoscopy. Am J Obstet Gynecol 105:1088–1098PubMed
14.
go back to reference Decker K, Fleiner R, Hirsch HA (1988) Laparoscopic findings in suspected adnexitis. Geburtshilfe Frauenheilkd 48:800–803PubMedCrossRef Decker K, Fleiner R, Hirsch HA (1988) Laparoscopic findings in suspected adnexitis. Geburtshilfe Frauenheilkd 48:800–803PubMedCrossRef
15.
go back to reference Westrom L, Mardh PA (1990) Acute pelvic inflammatory disease. In: Holmes et al (eds) Sexually transmitted diseases, Mc Graw-Hill, New York, p 593–620 Westrom L, Mardh PA (1990) Acute pelvic inflammatory disease. In: Holmes et al (eds) Sexually transmitted diseases, Mc Graw-Hill, New York, p 593–620
16.
go back to reference Mendling W (2013) Gynecological infections, part 2: cervicitis, salpingitis and herpes genitalis. Der Gynakol 2:118–128 Mendling W (2013) Gynecological infections, part 2: cervicitis, salpingitis and herpes genitalis. Der Gynakol 2:118–128
18.
go back to reference Cibula D, Kuzel D, Fucikova Z, Svabik K, Zivny J (2001) Acute exacerbation of recurrent pelvic inflammatory disease. Laparoscopic findings in 141 women with a clinical diagnosis. J Reprod Med 46:49–53PubMed Cibula D, Kuzel D, Fucikova Z, Svabik K, Zivny J (2001) Acute exacerbation of recurrent pelvic inflammatory disease. Laparoscopic findings in 141 women with a clinical diagnosis. J Reprod Med 46:49–53PubMed
19.
go back to reference Maleckiene L, Kajenas S, Nadisauskiene RJ, Railaite DR (2009) Comparison of clinical and laparoscopic diagnoses of pelvic inflammatory disease. Int J Gynaecol Obstet 104:74–75PubMedCrossRef Maleckiene L, Kajenas S, Nadisauskiene RJ, Railaite DR (2009) Comparison of clinical and laparoscopic diagnoses of pelvic inflammatory disease. Int J Gynaecol Obstet 104:74–75PubMedCrossRef
20.
go back to reference Molander P, Cacciatore B, Sjoberg J, Paavonen J (2000) Laparoscopic management of suspected acute pelvic inflammatory disease. J Am Assoc Gynecol Laparosc 7:107–110PubMedCrossRef Molander P, Cacciatore B, Sjoberg J, Paavonen J (2000) Laparoscopic management of suspected acute pelvic inflammatory disease. J Am Assoc Gynecol Laparosc 7:107–110PubMedCrossRef
21.
go back to reference Lurie S, Asaala H, Harari OS, Golan A, Sadan O (2010) Uterine cervical non-gonococcal and non-chlamydial bacterial flora and its antibiotic sensitivity in women with pelvic inflammatory disease: did it vary over 20 years? Isr Med Assoc J 12:747–750PubMed Lurie S, Asaala H, Harari OS, Golan A, Sadan O (2010) Uterine cervical non-gonococcal and non-chlamydial bacterial flora and its antibiotic sensitivity in women with pelvic inflammatory disease: did it vary over 20 years? Isr Med Assoc J 12:747–750PubMed
22.
go back to reference Audu BM, Kudi AA (2004) Microbial isolates and antibiogram from endocervical swabs of patients with pelvic inflammatory disease. J Obstet Gynaecol 24:161–164PubMedCrossRef Audu BM, Kudi AA (2004) Microbial isolates and antibiogram from endocervical swabs of patients with pelvic inflammatory disease. J Obstet Gynaecol 24:161–164PubMedCrossRef
23.
go back to reference Judlin P, Liao Q, Liu Z, Reimnitz P, Hampel B, Arvis P (2010) Efficacy and safety of moxifloxacin in uncomplicated pelvic inflammatory disease: the MONALISA study. BJOG 117:1475–1484PubMedCrossRef Judlin P, Liao Q, Liu Z, Reimnitz P, Hampel B, Arvis P (2010) Efficacy and safety of moxifloxacin in uncomplicated pelvic inflammatory disease: the MONALISA study. BJOG 117:1475–1484PubMedCrossRef
24.
go back to reference Leli C, Mencacci A, Bombaci JC, D’Alo F, Farinelli S, Vitali M, Montagna P, Bietolini C, Meucci M, Perito S, Bistoni F (2012) Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in a population of Italian and immigrant outpatients. Infez Med 20:82–87PubMed Leli C, Mencacci A, Bombaci JC, D’Alo F, Farinelli S, Vitali M, Montagna P, Bietolini C, Meucci M, Perito S, Bistoni F (2012) Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in a population of Italian and immigrant outpatients. Infez Med 20:82–87PubMed
25.
go back to reference Viberga I, Odlind V, Lazdane G, Kroica J, Berglund L, Olofsson S (2005) Microbiology profile in women with pelvic inflammatory disease in relation to IUD use. Infect Dis Obstet Gynecol 13:183–190PubMedCentralPubMedCrossRef Viberga I, Odlind V, Lazdane G, Kroica J, Berglund L, Olofsson S (2005) Microbiology profile in women with pelvic inflammatory disease in relation to IUD use. Infect Dis Obstet Gynecol 13:183–190PubMedCentralPubMedCrossRef
26.
go back to reference Pal Z, Urban E, Dosa E, Pal A, Nagy E (2005) Biofilm formation on intrauterine devices in relation to duration of use. J Med Microbiol 54:1199–1203PubMedCrossRef Pal Z, Urban E, Dosa E, Pal A, Nagy E (2005) Biofilm formation on intrauterine devices in relation to duration of use. J Med Microbiol 54:1199–1203PubMedCrossRef
27.
go back to reference Tsanadis G, Kalantaridou SN, Kaponis A, Paraskevaidis E, Zikopoulos K, Gesouli E, Dalkalitsis N, Korkontzelos I, Mouzakioti E, Lolis DE (2002) Bacteriological cultures of removed intrauterine devices and pelvic inflammatory disease. Contraception 65:339–342PubMedCrossRef Tsanadis G, Kalantaridou SN, Kaponis A, Paraskevaidis E, Zikopoulos K, Gesouli E, Dalkalitsis N, Korkontzelos I, Mouzakioti E, Lolis DE (2002) Bacteriological cultures of removed intrauterine devices and pelvic inflammatory disease. Contraception 65:339–342PubMedCrossRef
28.
go back to reference Swidsinski A, Verstraelen H, Loening-Baucke V, Swidsinski S, Mendling W, Halwani Z (2013) Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One 8:e53997PubMedCentralPubMedCrossRef Swidsinski A, Verstraelen H, Loening-Baucke V, Swidsinski S, Mendling W, Halwani Z (2013) Presence of a polymicrobial endometrial biofilm in patients with bacterial vaginosis. PLoS One 8:e53997PubMedCentralPubMedCrossRef
29.
go back to reference Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM (2012) Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS 23:18–24PubMedCrossRef Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM (2012) Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS 23:18–24PubMedCrossRef
30.
go back to reference Hoyme U, Kentner A, Mylonas I (2012) Laparoscopic diagnosis of chlamydial pelvic inflammatory disease and its impact on chlamydia screening programmes. Eur Obstet Gynaecol 7(1):9–13 Hoyme U, Kentner A, Mylonas I (2012) Laparoscopic diagnosis of chlamydial pelvic inflammatory disease and its impact on chlamydia screening programmes. Eur Obstet Gynaecol 7(1):9–13
31.
go back to reference Heinonen PK, Miettinen A (1994) Laparoscopic study on the microbiology and severity of acute pelvic inflammatory disease. Eur J Obstet Gynecol Reprod Biol 57:85–89PubMedCrossRef Heinonen PK, Miettinen A (1994) Laparoscopic study on the microbiology and severity of acute pelvic inflammatory disease. Eur J Obstet Gynecol Reprod Biol 57:85–89PubMedCrossRef
32.
go back to reference Hoyme UB, Swacek J (1984) Chlamydia trachomatis—laparoscopy specimen-taking and diagnosis of salpingitis. Geburtshilfe Frauenheilkd 44:307–310PubMedCrossRef Hoyme UB, Swacek J (1984) Chlamydia trachomatis—laparoscopy specimen-taking and diagnosis of salpingitis. Geburtshilfe Frauenheilkd 44:307–310PubMedCrossRef
33.
go back to reference Arora U, Mohan U (1997) Microbial profile of pelvic inflammatory disease. Indian J Med Sci 51:386–389PubMed Arora U, Mohan U (1997) Microbial profile of pelvic inflammatory disease. Indian J Med Sci 51:386–389PubMed
34.
go back to reference Hoyme UB (2006) Uterine and adnexal inflammatory disease. Gynakologe 39:981–995CrossRef Hoyme UB (2006) Uterine and adnexal inflammatory disease. Gynakologe 39:981–995CrossRef
35.
go back to reference Mendling W, Krasemann C (1986) Bacteriologic findings and therapeutic consequences in adnexitis. Geburtshilfe Frauenheilkd 46:462–466PubMedCrossRef Mendling W, Krasemann C (1986) Bacteriologic findings and therapeutic consequences in adnexitis. Geburtshilfe Frauenheilkd 46:462–466PubMedCrossRef
36.
go back to reference Judlin P, Thiebaugeorges O (2009) Levofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: a preliminary study. Eur J Obstet Gynecol Reprod Biol 145:177–179PubMedCrossRef Judlin P, Thiebaugeorges O (2009) Levofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: a preliminary study. Eur J Obstet Gynecol Reprod Biol 145:177–179PubMedCrossRef
37.
go back to reference Peipert JF, Sweet RL, Walker CK, Kahn J, Rielly-Gauvin K (1999) Evaluation of ofloxacin in the treatment of laparoscopically documented acute pelvic inflammatory disease (salpingitis). Infect Dis Obstet Gynecol 7:138–144PubMedCentralPubMedCrossRef Peipert JF, Sweet RL, Walker CK, Kahn J, Rielly-Gauvin K (1999) Evaluation of ofloxacin in the treatment of laparoscopically documented acute pelvic inflammatory disease (salpingitis). Infect Dis Obstet Gynecol 7:138–144PubMedCentralPubMedCrossRef
38.
go back to reference Haggerty CL, Ness RB (2007) Newest approaches to treatment of pelvic inflammatory disease: a review of recent randomized clinical trials. Clin Infect Dis 44:953–960PubMedCrossRef Haggerty CL, Ness RB (2007) Newest approaches to treatment of pelvic inflammatory disease: a review of recent randomized clinical trials. Clin Infect Dis 44:953–960PubMedCrossRef
39.
go back to reference Morcos R, Frost N, Hnat M, Petrunak A, Caldito G (1993) Laparoscopic versus clinical diagnosis of acute pelvic inflammatory disease. J Reprod Med 38:53–56PubMed Morcos R, Frost N, Hnat M, Petrunak A, Caldito G (1993) Laparoscopic versus clinical diagnosis of acute pelvic inflammatory disease. J Reprod Med 38:53–56PubMed
40.
go back to reference Livengood CH 3rd, Hill GB, Addison WA (1992) Pelvic inflammatory disease: findings during inpatient treatment of clinically severe, laparoscopy-documented disease. Am J Obstet Gynecol 166:519–524PubMedCrossRef Livengood CH 3rd, Hill GB, Addison WA (1992) Pelvic inflammatory disease: findings during inpatient treatment of clinically severe, laparoscopy-documented disease. Am J Obstet Gynecol 166:519–524PubMedCrossRef
41.
go back to reference Burchell HJ, Schoon MG (1987) The value of laparoscopy in the diagnosis of acute pelvic inflammatory disease. S Afr Med J 72:197–198PubMed Burchell HJ, Schoon MG (1987) The value of laparoscopy in the diagnosis of acute pelvic inflammatory disease. S Afr Med J 72:197–198PubMed
Metadata
Title
Diagnosis of pelvic inflammatory disease (PID): intra-operative findings and comparison of vaginal and intra-abdominal cultures
Authors
Christian Schindlbeck
Dominik Dziura
Ioannis Mylonas
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 6/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-014-3150-7

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