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Archives of Gynecology and Obstetrics

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01-05-2014 | Gynecologic Oncology

Comparison of Iodine-125 seeds implantation and afterloading radiotherapy in murine models of human cervical cancer

Authors: Hai-xia Li, Jing Zhao, Keng Shen, Jia-xin Yang, Fu-quan Zhang, Jie Chen

Published in: Archives of Gynecology and Obstetrics | Issue 5/2014

Abstract

Objective

To compare the efficacies and side effects of Iodine-125 (¹²⁵I) seeds implantation with afterloading radiotherapy on tumor xenografts derived from Hela cells.

Methods

Mice bearing Hela cells were randomly divided into three groups: two therapeutic groups receiving four ¹²⁵I seeds implantation and afterloading therapy, respectively, and the one control group without any intervention. Comparisons were evaluated in aspects of curative efficacies (tumor volume, tumor inhibition rate and metastasis) and side effects (body weight, ovarian endocrine functions, skin lesion surrounding the tumor).

Results

The xenografts tumor volume of therapeutic groups were significantly smaller than that of controls(p < 0.05),both of the ¹²⁵I seeds implantation and afterloading therapy showed excellent tumor inhibition rate. Furthermore, ¹²⁵I seeds implantation had milder side effects on skin, weight loss, ovarian endocrine functions.

Conclusions

¹²⁵I seed implantation may be an alternative minimally invasive therapy for cervical cancer.

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Title: Comparison of Iodine-125 seeds implantation and afterloading radiotherapy in murine models of human cervical cancer
Authors: Hai-xia Li
Jing Zhao
Keng Shen
Jia-xin Yang
Fu-quan Zhang
Jie Chen
Publication date: 01-05-2014
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-3107-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of Iodine-125 seeds implantation and afterloading radiotherapy in murine models of human cervical cancer

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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