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Archives of Gynecology and Obstetrics

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01-01-2014 | Review

Mechanism of pain generation for endometriosis-associated pelvic pain

Authors: Hiroshi Kobayashi, Yuki Yamada, Sachiko Morioka, Emiko Niiro, Aiko Shigemitsu, Fuminori Ito

Published in: Archives of Gynecology and Obstetrics | Issue 1/2014

Abstract

Purpose

Endometriosis-associated pelvic pain appears due to persistent nociceptive stimulation, but the precise mechanisms remain poorly understood.

Methods

A search was conducted to screen and select articles from PubMed.

Main results

Neurotrophins (NTs), a family of neuronal growth factors, are overexpressed in endometriosis and encompass NGF, BDNF and NT-3 and NT-4/5. NT receptors, TrkA and p75NTR, and NT receptor-interacting proteins, MAGE and NDN, were also expressed. NTs and their receptors play a role in the development and maintenance of neural tissues in non-neuronal cell types such as endometriosis. Nerve fibers contain unmyelinated sensory C, myelinated sensory Adelta and adrenergic nerve fibers that innervate abnormal cell growths. An increased release of proinflammatory cytokines from endometriotic lesions is responsible for the excessive sensory innervation and development of chronic pelvic pain.

Conclusions

The preponderance of the inflammatory milieu and subsequent hyperinnervation might be involved in the pathophysiology of pain generation in women with endometriosis.

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Title: Mechanism of pain generation for endometriosis-associated pelvic pain
Authors: Hiroshi Kobayashi
Yuki Yamada
Sachiko Morioka
Emiko Niiro
Aiko Shigemitsu
Fuminori Ito
Publication date: 01-01-2014
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2014
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-3049-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Mechanism of pain generation for endometriosis-associated pelvic pain

Abstract

Purpose

Methods

Main results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Main results

Conclusions

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