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01-10-2013 | General Gynecology

Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Authors: Gaspare Cucinella, Roberta Granese, Gloria Calagna, Alessandro Svelato, Salvatore Saitta, Gabriele Tonni, Pasquale De Franciscis, Nicola Colacurci, Antonino Perino

Published in: Archives of Gynecology and Obstetrics | Issue 4/2013

Abstract

Objective

The primary aim of the study was to analyze the endometrioma recurrence rate in patients who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs).

Materials and methods

168 patients who underwent a conservative laparoscopic surgery for endometrioma, during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all women following surgery. Patients were randomly divided into three groups according to different progestins used (desogestrel, gestodene, dienogest). Women who refused a postoperative hormonal therapy served as control. Follow-up visits and transvaginal scan were planned at 1, 3, 6, 12, and 24 months after surgery. All patients who showed an ultrasound persistence of the endometrioma at 1 month follow-up were excluded from clinical analysis.

Results

Of the 168 patients, 131 completed the 24 months follow-up. Endometrioma recurrence was found in 21 (12.5 %) of all patients, it was unilateral in 17 cases while bilateral in 4 cases. The rate of recurrent endometrioma was statistically significant in non-users compared to the long-term OCs treated patients.

Conclusion

The current data suggest the usefulness of long-term OCs regimen after conservative surgery for the prevention of ovarian endometrioma recurrence. As a statistical significant difference could not be observed between OCs groups, further study on the individual molecules is required in order to really understand the effect of each of them.

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Title: Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?
Authors: Gaspare Cucinella
Roberta Granese
Gloria Calagna
Alessandro Svelato
Salvatore Saitta
Gabriele Tonni
Pasquale De Franciscis
Nicola Colacurci
Antonino Perino
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-2841-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Abstract

Objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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