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Archives of Gynecology and Obstetrics

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01-05-2013 | Reproductive Medicine

Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology

Authors: Maryam Eftekhar, Abbas Aflatoonian, Farnaz Mohammadian, Tahereh Eftekhar

Published in: Archives of Gynecology and Obstetrics | Issue 5/2013

Abstract

Purpose

The incidence of poor ovarian response in controlled ovarian stimulation (COH) has been reported in 9–24 % of IVF-ET cycles. Growth hormone augments the effect of gonadotropin on granulosa and theca cells, and plays an essential role in ovarian function, including follicular development, estrogen synthesis and oocyte maturation. The aim of this study was to assess IVF-ET cycle outcome after the addition of growth hormone in antagonist protocol in poor responders.

Materials and methods

Eighty-two poor responder patients selected for ART enrolled the study and were randomly divided into two groups. Group I (GH/HMG/GnRHant group, n = 40) received growth hormone/gonadotropin/GnRH antagonist protocol and group II (HMG/GnRHant group, n = 42) received gonadotropin/GnRH antagonist protocol.

Results

The number of retrieved oocytes was significantly higher in GH/HMG/GnRHant group than HMG/GnRHant group, 6.10 ± 2.90 vs. 4.80 ± 2.40 (p = 0.035) and the number of obtained embryos was also significantly higher in GH/HMG/GnRHant group than HMG/GnRHant group, 3.7 ± 2.89 as compared to 2.7 ± 1.29 (p = 0.018). There were no significant differences between groups regarding implantation, and chemical and clinical pregnancy rates.

Conclusion

Our study showed that co-treatment with growth hormone in antagonist protocol in patients with a history of poor response in previous IVF-ET cycles did not increase pregnancy rates.

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Title: Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology
Authors: Maryam Eftekhar
Abbas Aflatoonian
Farnaz Mohammadian
Tahereh Eftekhar
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 5/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2655-1

At a glance: The STEP trials

Springer Medicine

Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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