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Archives of Gynecology and Obstetrics

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01-04-2013 | Reproductive Medicine

Analysis of sperm telomere length in men with idiopathic infertility

Authors: J. Thilagavathi, M. Kumar, S. S. Mishra, S. Venkatesh, R. Kumar, R. Dada

Published in: Archives of Gynecology and Obstetrics | Issue 4/2013

Abstract

Purpose

Telomeres are multifunctional nucleoprotein domains with hexanucleotide tandem repeat (5′ TTAGGG 3′) sequences, which cap the chromosome ends. However, the role of telomere and its length in sperm with regard to fertility remains unknown.

Methods

In this pilot study, we analyzed 32 idiopathic infertile men and 25 controls for sperm telomere length by quantitative polymerase chain reaction (Q-PCR), and correlated it with sperm DNA fragmentation index (DFI) and reactive oxygen species (ROS) levels.

Results

The relative sperm mean telomere length (T/S) of infertile men was found to be significantly lower (p < 0.005) when compared to controls (0.674 ± 0.028 vs. 0.699 ± 0.030). None of the sperm parameters such as sperm count, forward motility, morphology, ROS, and DFI were found to correlate with the sperm telomere length.

Conclusion

Shorter telomeres in sperm may be one of the causative factors responsible for male infertility, but further detailed studies are needed to confirm these findings.

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Title: Analysis of sperm telomere length in men with idiopathic infertility
Authors: J. Thilagavathi
M. Kumar
S. S. Mishra
S. Venkatesh
R. Kumar
R. Dada
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 4/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2632-8

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Springer Medicine

Analysis of sperm telomere length in men with idiopathic infertility

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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