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Archives of Gynecology and Obstetrics

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01-04-2012 | General Gynecology

Bone mineral density is not associated with homocysteine level, folate and vitamin B₁₂ status

Authors: Ivana Rumbak, Vesna Žižić, Lea Sokolić, Selma Cvijetić, Romana Kajfež, Irena Colić Barić

Published in: Archives of Gynecology and Obstetrics | Issue 4/2012

Abstract

Purpose

The relationship of homocysteine (Hcy), folate and vitamin B₁₂ with bone mineral density (BMD) has been studied in various populations but still remains inconsistent. The aim of this study was to test whether the levels of plasma Hcy, serum and red blood cell folate, and vitamin B₁₂ are related to BMD in the group of adult Croatian women regardless of menopausal status. Some other lifestyle and dietary habits like smoking, physical activity and alcohol consumption were also observed in relation to BMD.

Methods

One-hundred and thirty-one women, aged 45–65 years participated in the study. BMD was measured using dual-energy X-ray absorptiometry. Measurements were made at the lumbar spine (L1–L4), left femoral neck, total femur and distal third of the radius. Plasma total Hcy, serum folate, red blood cell folate and serum vitamin B₁₂ were also determined.

Results

No significant correlations were found between Hcy, folate and/or vitamin B₁₂ and BMD of measured skeletal sites. Body mass index (BMI), age, as well as alcohol consumption were significantly correlated with BMD at the lumbar spine. Positive significant correlation was found between BMI and BMD at the femoral neck and total femur while BMI and age were significant predictors of BMD at the radius (multiple regression analysis). When only postmenopausal women were included, significant predictors of BMD at the lumbar spine were age, BMI, alcohol consumption and intake of hormone replacement therapy.

Conclusion

Results of this study suggest that Hcy, folate or vitamin B₁₂ levels were not related to BMD in population of healthy Croatian women aged 45–65. In the group of postmenopausal Croatian women, beside BMI and age, alcohol consumption was significant positive predictor of BMD at the lumbar spine.

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Title: Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status
Authors: Ivana Rumbak
Vesna Žižić
Lea Sokolić
Selma Cvijetić
Romana Kajfež
Irena Colić Barić
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 4/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2079-3

At a glance: The STEP trials

Springer Medicine

Bone mineral density is not associated with homocysteine level, folate and vitamin B₁₂ status

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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