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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 4/2011

01-10-2011 | Materno-fetal Medicine

Role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum

Authors: Ghada M. Mansour, Ehab H. Nashaat

Published in: Archives of Gynecology and Obstetrics | Issue 4/2011

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Abstract

Purpose

To evaluate the role of Helicobacter pylori (H. pylori) in the pathogenesis of hyperemesis gravidarum (HG) and the value of adding a non teratogenic regimen for its treatment in intractable cases.

Methods

Eighty hyperemesis gravidarum cases were recruited from Ain Shams University out patient clinics. A complete history was taken including history of medical disorders and chronic medications intake as non steroidal anti-inflammatory drugs. After general and local examination, ultrasound was done for all cases to exclude obstetric causes of hyperemesis. Eighty normal pregnant women acted as control. Serum test for H. pylori IgG antibody titre was done for all patients and controls.

Results

Seventy-one cases among the 80 HG cases and twenty-four out of the 80 controls were H. pylori positive. Eight HG cases developed severe intractable vomiting. Three of them developed attacks of hematemesis. Gastroscopy done for the eight cases revealed antral gastritis and duodenitis. Gastric and duodenal erosions were found in two cases. The eight patients received a non teratogenic regimen for treatment. Attacks of vomiting decreased and pregnancy continued till delivery of healthy newborns.

Conclusion

Screening for H. pylori should be added to the investigations of hyperemesis gravidarum cases. Non teratogenic treatment can be considered in intractable cases.
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Metadata
Title
Role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum
Authors
Ghada M. Mansour
Ehab H. Nashaat
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 4/2011
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-010-1759-8

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